| Entry |
|
|---|
| Name |
Tegafur (JP18/USAN/INN);
Atillon (TN) |
|---|
| Formula |
C8H9FN2O3
|
|---|
| Exact mass |
200.0597
|
|---|
| Mol weight |
200.1671
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antineoplastic
DG02018 Antimetabolite
DG01958 Nucleic acid derivative, antineoplastic
DG01935 Fluoropyrimidine antineoplastic
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
|
|---|
| Remark |
| Product (mixture): | D02131<JP> D06399<JP> |
|
|---|
| Efficacy |
Antineoplastic, Antimetabolite |
|---|
| Comment |
Active form of prodrug: Fluorouracil [DR: D00584]
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2A6 [HSA: 1548]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07041 | Antineoplastics - antimetabolic agents |
|
|---|
| Other map |
| map00983 | Drug metabolism - other enzymes |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01B ANTIMETABOLITES
L01BC Pyrimidine analogues
L01BC03 Tegafur
D01244 Tegafur (JP18/USAN/INN)
Drug groups [BR:br08330]
Antineoplastic
DG02018 Antimetabolite
DG01958 Nucleic acid derivative, antineoplastic
DG01935 Fluoropyrimidine antineoplastic
D01244 Tegafur
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
D01244 Tegafur
Target-based classification of drugs [BR:br08310]
Enzymes
Transferases (EC2)
Methyltransferases
TYMS
D01244 Tegafur (JP18/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01244 Tegafur
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01244
Prodrugs [br08324.html]
D01244
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 14
1 C1y C 22.3760 -18.2217
2 O2x O 21.2472 -17.3849
3 C1x C 21.9301 -19.5480
4 C1x C 20.1024 -18.2004
5 C1x C 20.5236 -19.5348
6 N4y N 23.7960 -17.4047
7 C8y C 24.9907 -18.1227
8 C8x C 23.8098 -16.0038
9 N4x N 26.2164 -17.4363
10 O5x O 24.9714 -19.5247
11 C8y C 25.0353 -15.3174
12 C8y C 26.2357 -16.0341
13 O5x O 27.4626 -15.3536
14 X F 25.0542 -13.9477
BOND 15
1 1 2 1
2 1 3 1
3 2 4 1
4 3 5 1
5 4 5 1
6 6 7 1
7 6 8 1
8 7 9 1
9 7 10 2
10 8 11 2
11 9 12 1
12 12 13 2
13 11 12 1
14 11 14 1
15 1 6 1
|
|---|
