| Entry |
|
|---|
| Name |
Tofisopam (JP18/INN);
Emandaxin (TN) |
|---|
| Formula |
C22H26N2O4
|
|---|
| Exact mass |
382.1893
|
|---|
| Mol weight |
382.4528
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01567 GABA-A receptor agonist
DG01914 Anxiolytics, benzodiazepine derivatives
|
|---|
| Remark |
|
|---|
| Efficacy |
Antianxiety, Sedative-hypnotic |
|---|
| Comment |
Benzodiazepine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07230 | GABA-A receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05B ANXIOLYTICS
N05BA Benzodiazepine derivatives
N05BA23 Tofisopam
D01254 Tofisopam (JP18/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
112 Hypnotics and sedatives, anxiolytics
1124 Benzodiazepins
D01254 Tofisopam (JP18/INN)
12 Agents affecting peripheral nervous system
123 Autonomic nervous system agents
1239 Others
D01254 Tofisopam (JP18/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01567 GABA-A receptor agonist
D01254 Tofisopam
DG01914 Anxiolytics, benzodiazepine derivatives
D01254 Tofisopam
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D01254 Tofisopam (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01254 Tofisopam
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 28
1 C2y C 29.4618 -15.1158
2 C8y C 28.6220 -14.0661
3 C8y C 28.9719 -12.6665
4 C1y C 30.2316 -12.1066
5 N2x N 30.8614 -15.1158
6 C2y C 31.4912 -12.7364
7 N2x N 31.7711 -14.0661
8 C8x C 27.9922 -11.6867
9 C8y C 26.5926 -12.1066
10 C8y C 26.3127 -13.4362
11 C8x C 27.2924 -14.4160
12 C1a C 32.5409 -11.7567
13 C8y C 28.8319 -16.3754
14 C8x C 27.4323 -16.3754
15 C1b C 30.2316 -10.7070
16 C1a C 31.4912 -10.0072
17 O2a O 25.6128 -11.1269
18 C1a C 24.2832 -11.5468
19 C1a C 23.9333 -12.8764
20 O2a O 24.9130 -13.8561
21 C8y C 26.7325 -17.6351
22 C8y C 27.4323 -18.8247
23 C8x C 28.8319 -18.8247
24 C8x C 29.5318 -17.6351
25 O2a O 25.3329 -17.6351
26 C1a C 24.6331 -18.8247
27 C1a C 25.3329 -20.0144
28 O2a O 26.7325 -20.0144
BOND 30
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 2
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 6 12 1
14 1 13 1
15 13 14 1
16 4 15 1
17 15 16 1
18 9 17 1
19 17 18 1
20 19 20 1
21 10 20 1
22 14 21 2
23 21 22 1
24 22 23 2
25 23 24 1
26 13 24 2
27 21 25 1
28 25 26 1
29 27 28 1
30 22 28 1
|
|---|
