| Entry |
|
|---|
| Name |
Clobetasone butyrate (JAN/USAN);
Kindavate (TN) |
|---|
| Formula |
C26H32ClFO5
|
|---|
| Exact mass |
478.1922
|
|---|
| Mol weight |
478.9807
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Dermatological agent
DG03243 Atopic dermatitis agent
|
|---|
| Remark |
| Therapeutic category: | 2646 |
| Product (DG00411): | D01273<JP> |
|
|---|
| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB01 Clobetasone
D01273 Clobetasone butyrate (JAN/USAN) <JP>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA09 Clobetasone
D01273 Clobetasone butyrate (JAN/USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2646 Adrenocorticotropic hormones
D01273 Clobetasone butyrate (JAN/USAN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00411 Clobetasone
D01273 Clobetasone butyrate
Dermatological agent
DG03243 Atopic dermatitis agent
D01273 Clobetasone butyrate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D01273 Clobetasone butyrate
Dermatological agent
DG03243 Atopic dermatitis agent
D01273 Clobetasone butyrate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D01273 Clobetasone butyrate (JAN/USAN) <JP>
Topical steroids potency [br08317.html]
Classification in Japan
D01273
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00411 Clobetasone
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 33
1 C1z C 20.4972 -13.5753
2 C1z C 19.3183 -14.2583
3 C1y C 21.6762 -14.2640
4 O7a O 21.6820 -12.8866
5 C5a C 20.4855 -12.2038
6 C1y C 19.3183 -15.6181
7 C1x C 18.1393 -13.5695
8 C1a C 19.3124 -12.8692
9 C1x C 21.6703 -15.6240
10 C7a C 23.7011 -12.8866
11 C1b C 21.6879 -11.5092
12 O5a O 19.2833 -11.5209
13 C1y C 18.1335 -16.3010
14 C5x C 16.9545 -14.2523
15 X Cl 21.6762 -10.1201
16 C1z C 16.9487 -15.6181
17 C1x C 18.1393 -17.6667
18 O5x O 15.7639 -13.5579
19 C1z C 15.7697 -16.3010
20 X F 16.9428 -16.9780
21 C1x C 16.9545 -18.3554
22 C2y C 15.7697 -17.6725
23 C2x C 14.5849 -15.6181
24 C1a C 15.7580 -14.9353
25 C2x C 14.5849 -18.3554
26 C2x C 13.4001 -16.3010
27 C5x C 13.4001 -17.6725
28 O5x O 12.2096 -18.3495
29 C1a C 23.0687 -14.2613
30 O6a O 24.3993 -14.0959
31 C1b C 24.3993 -11.6773
32 C1b C 25.7956 -11.6773
33 C1a C 26.4938 -10.4681
BOND 36
1 2 6 1
2 2 7 1
3 2 8 1 #Up
4 3 9 1
5 4 10 1
6 5 11 1
7 5 12 2
8 6 13 1
9 7 14 1
10 11 15 1
11 13 16 1
12 13 17 1
13 14 18 2
14 16 19 1
15 16 20 1 #Down
16 17 21 1
17 19 22 1
18 19 23 1
19 19 24 1 #Up
20 22 25 2
21 23 26 2
22 25 27 1
23 27 28 2
24 6 9 1
25 14 16 1
26 21 22 1
27 26 27 1
28 3 29 1 #Up
29 1 2 1
30 10 30 2
31 1 3 1
32 10 31 1
33 1 4 1 #Down
34 31 32 1
35 1 5 1 #Up
36 32 33 1
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|---|
