KEGG   DRUG: Tesaglitazar
Entry
D01274                      Drug                                   
Name
Tesaglitazar (JAN/USAN/INN)
Formula
C20H24O7S
Exact mass
408.1243
Mol weight
408.4654
Structure
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01795  PPAR gamma agonist
   DG01732  Non-thiazolidinedione type PPAR agonist
Efficacy
Antidiabetic
Comment
Treatment of type 2 diabetes and insulin resistance syndrome
Target
NR1C1 (PPARA) [HSA:5465] [KO:K07294]
NR1C3 (PPARG) [HSA:5468] [KO:K08530]
  Pathway
hsa03320  PPAR signaling pathway
hsa04922  Glucagon signaling pathway
Interaction
Brite
Drug groups [BR:br08330]
 Antidiabetic agent
  DG01685  Insulin sensitizer
   DG01795  PPAR gamma agonist
    DG01732  Non-thiazolidinedione type PPAR agonist
     D01274  Tesaglitazar
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    NR1C1 (PPARA)
     D01274  Tesaglitazar (JAN/USAN/INN)
    NR1C3 (PPARG)
     D01274  Tesaglitazar (JAN/USAN/INN)
Other DBs
CAS: 251565-85-2
PubChem: 7848337
ChEBI: 32195
PDB-CCD: AZ2[PDBj]
LigandBox: D01274
KCF data

ATOM        28
            1   C8x C    13.1613  -17.5017
            2   C8y C    13.1613  -16.1016
            3   C8x C    14.3514  -15.4015
            4   C8x C    15.6115  -16.1016
            5   C8y C    15.6115  -17.5017
            6   C8x C    14.3514  -18.2018
            7   C1b C    16.8017  -18.2018
            8   C1b C    17.9918  -17.5717
            9   O2a O    19.1819  -18.2718
            10  C8y C    20.4420  -17.5717
            11  C8x C    20.4420  -16.1716
            12  C8x C    21.6321  -15.4715
            13  C8y C    22.8223  -16.1716
            14  C8x C    22.8223  -17.5717
            15  C8x C    21.6321  -18.2718
            16  O2a O    11.9712  -15.4015
            17  S4a S    10.7111  -16.1016
            18  C1a C     9.5209  -15.4015
            19  C1b C    24.0824  -15.4715
            20  C1c C    25.2725  -16.1716
            21  C6a C    26.4626  -15.4715
            22  O6a O    26.4626  -14.0714
            23  O6a O    27.6527  -16.1716
            24  O2a O    25.2725  -17.5717
            25  C1b C    26.4626  -18.2718
            26  O3c O    11.6912  -17.1517
            27  O3c O     9.7310  -17.1517
            28  C1a C    27.7227  -17.5717
BOND        29
            1    12  13 2
            2    13  14 1
            3    14  15 2
            4    15  10 1
            5     1   2 2
            6     2  16 1
            7     7   8 1
            8    16  17 1
            9     2   3 1
            10   17  18 1
            11    8   9 1
            12   13  19 1
            13    3   4 2
            14   19  20 1
            15    9  10 1
            16   20  21 1
            17    4   5 1
            18   21  22 2
            19    5   6 2
            20   21  23 1
            21    6   1 1
            22   20  24 1 #Up
            23   24  25 1
            24    5   7 1
            25   17  26 2
            26   10  11 2
            27   17  27 2
            28   11  12 1
            29   25  28 1

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  All links  
Ontology (2)   
   KEGG BRITE (2)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   PDB-CCD (1)   
Gene (4)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (2)   
All databases (11)   

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