| Entry |
|
|---|
| Name |
Ethyl loflazepate (JP18/INN);
Meilax (TN) |
|---|
| Formula |
C18H14ClFN2O3
|
|---|
| Exact mass |
360.0677
|
|---|
| Mol weight |
360.7668
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01567 GABA-A receptor agonist
DG01914 Anxiolytics, benzodiazepine derivatives
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 1124 |
|
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| Efficacy |
Antianxiety |
|---|
| Comment |
Benzodiazepine derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
| map07230 | GABA-A receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05B ANXIOLYTICS
N05BA Benzodiazepine derivatives
N05BA18 Ethyl loflazepate
D01293 Ethyl loflazepate (JP18/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
112 Hypnotics and sedatives, anxiolytics
1124 Benzodiazepins
D01293 Ethyl loflazepate (JP18/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01567 GABA-A receptor agonist
D01293 Ethyl loflazepate
DG01914 Anxiolytics, benzodiazepine derivatives
D01293 Ethyl loflazepate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D01293 Ethyl loflazepate
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D01293 Ethyl loflazepate (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01293 Ethyl loflazepate
D01293 Ethyl loflazepate tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01293
Narcotics and psychotropics in Japan [br08308.html]
Psychotropics by Cabinet order Article 3 (78 substances)
D01293
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| Other DBs |
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| KCF data |
ATOM 25
1 C2y C 19.3834 -15.4794
2 C8y C 18.5413 -14.3698
3 C8y C 18.8765 -13.0130
4 N1x N 20.1375 -12.4349
5 N2x N 20.7892 -15.5046
6 C5x C 21.3911 -13.0572
7 C1y C 21.6776 -14.4259
8 C8x C 17.8694 -12.0446
9 C8x C 16.5274 -12.4327
10 C8y C 16.1922 -13.7895
11 C8x C 17.1993 -14.7576
12 X Cl 14.8274 -14.1839
13 C8y C 18.7489 -16.7291
14 C8x C 17.3473 -16.7291
15 C8x C 16.6473 -17.9416
16 C8x C 17.3473 -19.1540
17 C8x C 18.7489 -19.1540
18 C8y C 19.4489 -17.9416
19 X F 20.8598 -17.9417
20 C7a C 22.8901 -15.1259
21 O7a O 24.1025 -14.4259
22 O5x O 22.5003 -12.1995
23 O6a O 22.8901 -16.5200
24 C1b C 25.2954 -15.1148
25 C1a C 26.4865 -14.4271
BOND 27
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 10 12 1
14 1 13 1
15 13 14 1
16 14 15 2
17 15 16 1
18 16 17 2
19 17 18 1
20 13 18 2
21 18 19 1
22 7 20 1
23 20 21 1
24 6 22 2
25 20 23 2
26 21 24 1
27 24 25 1
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