| Entry |
|
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| Name |
Cinnarizine (JAN/USAN/INN) |
|---|
| Formula |
C26H28N2
|
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| Exact mass |
368.2252
|
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| Mol weight |
368.5139
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
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| Remark |
|
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| Efficacy |
Anti-emetic, Antivertigo, H1 receptor antagonist |
|---|
| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
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| Interaction |
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07C ANTIVERTIGO PREPARATIONS
N07CA Antivertigo preparations
N07CA02 Cinnarizine
D01295 Cinnarizine (JAN/USAN/INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01005 Cinnarizine
D01295 Cinnarizine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01005 Cinnarizine
D01295 Cinnarizine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D01295 Cinnarizine (JAN/USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01295
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01005 Cinnarizine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01005 Cinnarizine
|
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| Other DBs |
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| KCF data |
ATOM 28
1 C8x C 7.7700 -17.9900
2 C8x C 7.7700 -19.3900
3 C8x C 8.9824 -20.0900
4 C8x C 10.1949 -19.3900
5 C8y C 10.1949 -17.9900
6 C8x C 8.9824 -17.2900
7 C8x C 12.6197 -19.3900
8 C8y C 12.6197 -17.9900
9 C1c C 11.4073 -17.2900
10 C8x C 13.8322 -20.0900
11 C8x C 15.0446 -19.3900
12 C8x C 15.0446 -17.9900
13 C8x C 13.8322 -17.2900
14 N1y N 11.4073 -15.8900
15 C1x C 12.6218 -15.1888
16 C1x C 12.6218 -13.7888
17 N1y N 11.4093 -13.0888
18 C1x C 10.1949 -13.7900
19 C1x C 10.1949 -15.1900
20 C1b C 11.4093 -11.6900
21 C2b C 12.6223 -10.9897
22 C2b C 13.8180 -11.6802
23 C8y C 15.0052 -10.9949
24 C8x C 16.1965 -11.6829
25 C8x C 17.4091 -10.9830
26 C8x C 17.4092 -9.5830
27 C8x C 16.2179 -8.8950
28 C8x C 15.0054 -9.5949
BOND 31
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 7 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 8 13 2
15 9 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 14 19 1
22 17 20 1
23 20 21 1
24 21 22 2
25 22 23 1
26 23 24 2
27 24 25 1
28 25 26 2
29 26 27 1
30 27 28 2
31 23 28 1
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