KEGG   DRUG: Hydralazine hydrochloride
Entry
D01302                      Drug                                   
Name
Hydralazine hydrochloride (JP18/USP);
Apresoline (TN)
Product
  Generic
HYDRALAZINE (Nivagen Pharmaceuticals), HYDRALAZINE HCL (DirectRX), HYDRALAZINE HYDROCHLORIDE (A-S Medication Solutions), HYDRALAZINE HYDROCHLORIDE (A-S Medication Solutions), HYDRALAZINE HYDROCHLORIDE (A-S Medication Solutions), HYDRALAZINE HYDROCHLORIDE (American Health Packaging), HYDRALAZINE HYDROCHLORIDE (American Health Packaging), HYDRALAZINE HYDROCHLORIDE (American Health Packaging), HYDRALAZINE HYDROCHLORIDE (American Regent), HYDRALAZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDRALAZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDRALAZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDRALAZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDRALAZINE HYDROCHLORIDE (Ascend Laboratories), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Cadila Pharmaceuticals Limited), HYDRALAZINE HYDROCHLORIDE (Camber Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Cardinal Health 107), HYDRALAZINE HYDROCHLORIDE (Cardinal Health 107), HYDRALAZINE HYDROCHLORIDE (Cardinal Health 107), HYDRALAZINE HYDROCHLORIDE (Cardinal Health 107), HYDRALAZINE HYDROCHLORIDE (Cardinal Health 107), HYDRALAZINE HYDROCHLORIDE (Chartwell RX), HYDRALAZINE HYDROCHLORIDE (Civica), HYDRALAZINE HYDROCHLORIDE (Denton Pharma), HYDRALAZINE HYDROCHLORIDE (Denton Pharma), HYDRALAZINE HYDROCHLORIDE (Direct_Rx), HYDRALAZINE HYDROCHLORIDE (Eugia US LLC), HYDRALAZINE HYDROCHLORIDE (Exelan Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Fresenius Kabi USA), HYDRALAZINE HYDROCHLORIDE (Fresenius Kabi USA), HYDRALAZINE HYDROCHLORIDE (Fresenius Kabi USA), HYDRALAZINE HYDROCHLORIDE (HF Acquisition Co LLC), HYDRALAZINE HYDROCHLORIDE (HF Acquisition Co LLC), HYDRALAZINE HYDROCHLORIDE (Henry Schein), HYDRALAZINE HYDROCHLORIDE (Henry Schein), HYDRALAZINE HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), HYDRALAZINE HYDROCHLORIDE (Major Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), HYDRALAZINE HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), HYDRALAZINE HYDROCHLORIDE (Medical Purchasing Solutions), HYDRALAZINE HYDROCHLORIDE (Medical Purchasing Solutions), HYDRALAZINE HYDROCHLORIDE (Medical Purchasing Solutions), HYDRALAZINE HYDROCHLORIDE (Medical Purchasing Solutions), HYDRALAZINE HYDROCHLORIDE (Modavar Pharmaceuticals LLC), HYDRALAZINE HYDROCHLORIDE (Mylan Institutional), HYDRALAZINE HYDROCHLORIDE (NCS HealthCare of KY), HYDRALAZINE HYDROCHLORIDE (Northwind Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Northwind Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Northwind Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Proficient Rx LP), HYDRALAZINE HYDROCHLORIDE (Proficient Rx LP), HYDRALAZINE HYDROCHLORIDE (Proficient Rx LP), HYDRALAZINE HYDROCHLORIDE (Proficient Rx LP), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (Radha Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (ScieGen Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Strides Pharma Science Limited), HYDRALAZINE HYDROCHLORIDE (Teva Pharmaceuticals USA)
Formula
C8H8N4. HCl
Exact mass
196.0516
Mol weight
196.6369
Structure
Simcomp
Class
Cardiovascular agent
 DG03231  Antihypertensive
 DG02046  Hydrazinophthalazine derivative
Metabolizing enzyme substrate
 DG02928  NAT substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 2142
ATC code: C02DB02
Chemical structure group: DG00261
Product (DG00261): D01302<JP/US>
Product (mixture): D10209<US>
Efficacy
Antihypertensive
  Disease
Essential hypertension [DS:H01633]
Comment
Hydrazinophthalazine derivative
Metabolism
Enzyme: NAT [HSA:9 10]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02D ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
    C02DB Hydrazinophthalazine derivatives
     C02DB02 Hydralazine
      D01302  Hydralazine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Vasodilators
   Vasodilators, Direct-acting Arterial
    Hydralazine
     D01302  Hydralazine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2142  Hydralazines
     D01302  Hydralazine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG00261  Hydralazine
    D01302  Hydralazine hydrochloride
  DG02046  Hydrazinophthalazine derivative
   DG00261  Hydralazine
    D01302  Hydralazine hydrochloride
 Metabolizing enzyme substrate
  DG02928  NAT substrate
   DG00261  Hydralazine
    D01302  Hydralazine hydrochloride
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00261  Hydralazine
    D01302  Hydralazine hydrochloride
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D01302  Hydralazine hydrochloride
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01302  Hydralazine hydrochloride
  D01302  Hydralazine hydrochloride tablets
  D01302  Hydralazine hydrochloride powder
  D01302  Hydralazine hydrochloride for injection
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01302
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG00261  Hydralazine
  DG02046  Hydrazinophthalazine derivative
   DG00261  Hydralazine
 Metabolizing enzyme substrate
  DG02928  NAT substrate
   DG00261  Hydralazine
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00261  Hydralazine
Other DBs
CAS: 304-20-1
PubChem: 7848365
ChEBI: 31672
LigandBox: D01302
NIKKAJI: J257.318K
KCF data

ATOM        13
            1   C8x C    19.0523  -16.4104
            2   C8x C    19.0523  -17.8110
            3   C8x C    20.2682  -18.5113
            4   C8x C    20.2682  -15.7101
            5   C8y C    21.4769  -16.4104
            6   C8y C    21.4710  -17.8110
            7   C8x C    22.6809  -18.5163
            8   N5x N    23.8968  -17.8213
            9   N5x N    23.9027  -16.4208
            10  C8y C    22.6928  -15.7154
            11  N1b N    22.6987  -14.3148
            12  N1a N    23.9148  -13.6196
            13  X   Cl   28.1844  -16.5518
BOND        13
            1     1   2 2
            2     2   3 1
            3     3   6 2
            4     5   4 2
            5     5   6 1
            6     6   7 1
            7     7   8 2
            8     8   9 1
            9     9  10 2
            10   10   5 1
            11    4   1 1
            12   10  11 1
            13   11  12 1

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Ontology (7)   
   KEGG BRITE (7)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (4)   
   PubChem (1)   
   ChEBI (1)   
   HSDB (1)   
   NIKKAJI (1)   
All databases (16)   

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