| Entry |
|
|---|
| Name |
Mexazolam (JAN/INN);
Melex (TN) |
|---|
| Formula |
C18H16Cl2N2O2
|
|---|
| Exact mass |
362.0589
|
|---|
| Mol weight |
363.2378
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
DG01567 GABA-A receptor agonist
DG01914 Anxiolytics, benzodiazepine derivatives
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 1124 |
|
|---|
| Efficacy |
Antianxiety |
|---|
| Comment |
Benzodiazepine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07230 | GABA-A receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05B ANXIOLYTICS
N05BA Benzodiazepine derivatives
N05BA25 Mexazolam
D01316 Mexazolam (JAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
112 Hypnotics and sedatives, anxiolytics
1124 Benzodiazepins
D01316 Mexazolam (JAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01835 Benzodiazepine sedative-hypnotics
D01316 Mexazolam
DG01567 GABA-A receptor agonist
D01316 Mexazolam
DG01914 Anxiolytics, benzodiazepine derivatives
D01316 Mexazolam
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D01316 Mexazolam
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D01316 Mexazolam (JAN/INN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01316
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 24
1 C1z C 22.2873 -12.4810
2 C8y C 21.4533 -11.3820
3 C8y C 21.7853 -10.0384
4 N1x N 23.0341 -9.4657
5 N1y N 23.6795 -12.4366
6 C5x C 24.2756 -10.0821
7 C1x C 24.5594 -11.4377
8 C8x C 20.7878 -9.0793
9 C8x C 19.4588 -9.4636
10 C8y C 19.1268 -10.8073
11 C8x C 20.1242 -11.7661
12 O5x O 25.3097 -9.1567
13 X Cl 17.7752 -11.1980
14 O2x O 21.8992 -13.8188
15 C1x C 23.0516 -14.6013
16 C1y C 24.1519 -13.7471
17 C8y C 20.6024 -13.1737
18 C8x C 19.4025 -12.4810
19 C8x C 18.2026 -13.1737
20 C8x C 18.2026 -14.5593
21 C8x C 19.4025 -15.2521
22 C8y C 20.6024 -14.5593
23 X Cl 21.8088 -15.2559
24 C1a C 25.4873 -14.1342
BOND 27
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 6 12 2
14 10 13 1
15 1 14 1
16 14 15 1
17 15 16 1
18 5 16 1
19 1 17 1
20 17 18 2
21 18 19 1
22 19 20 2
23 20 21 1
24 21 22 2
25 17 22 1
26 22 23 1
27 16 24 1
|
|---|
