| Entry |
|
|---|
| Name |
Zotepine (JAN/INN);
Setous (TN) |
|---|
| Formula |
C18H18ClNOS
|
|---|
| Exact mass |
331.0798
|
|---|
| Mol weight |
331.8596
|
|---|
| Structure |
|
|---|
| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03005 Serotonin-dopamine antagonist (SDA)
|
|---|
| Remark |
| Therapeutic category: | 1179 |
|
|---|
| Efficacy |
Antipsychotic, Dopamine D2 receptor antagonist, Serotonin receptor antagonist |
|---|
| Comment |
Tiepine derivative, Tricyclic compound
Serotonin-dopamine antagonist (SDA)
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AX Other antipsychotics
N05AX11 Zotepine
D01321 Zotepine (JAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D01321 Zotepine (JAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
D01321 Zotepine
DG03005 Serotonin-dopamine antagonist (SDA)
D01321 Zotepine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D01321 Zotepine (JAN/INN) <JP>
Serotonin
HTR1
D01321 Zotepine (JAN/INN) <JP>
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 22
1 C2y C 52.5000 -9.9400
2 C8y C 51.6600 -8.8200
3 C8y C 52.0100 -7.4900
4 S2x S 53.2700 -6.9300
5 C2x C 53.9000 -9.9400
6 C8y C 54.5300 -7.5600
7 C8y C 54.8100 -8.8900
8 C8x C 50.9600 -6.5100
9 C8x C 49.6300 -6.9300
10 C8y C 49.2800 -8.2600
11 C8x C 50.3300 -9.2400
12 C8x C 56.1400 -9.3100
13 C8x C 57.1900 -8.4000
14 C8x C 56.9100 -7.0000
15 C8x C 55.5800 -6.5800
16 X Cl 47.9500 -8.6800
17 O2a O 51.8700 -11.2000
18 C1b C 50.4700 -11.2000
19 C1b C 49.7700 -12.3900
20 N1c N 48.3700 -12.3900
21 C1a C 47.6700 -11.1776
22 C1a C 47.6700 -13.6024
BOND 24
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 10 16 1
19 1 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 20 22 1
|
|---|
