| Entry |
|
|---|
| Name |
Diflorasone diacetate (JP18/USP);
Florone (TN);
Psorcon (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C26H32F2O7
|
|---|
| Exact mass |
494.2116
|
|---|
| Mol weight |
494.5249
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Dermatological agent
DG03243 Atopic dermatitis agent
|
|---|
| Remark |
| Therapeutic category: | 2646 |
| Product (DG00418): | D01327<JP/US> |
|
|---|
| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AC Corticosteroids, potent (group III)
D07AC10 Diflorasone
D01327 Diflorasone diacetate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
Dermatitis and Pruitus Agents
Glucocorticoids, High Potency
Diflorasone
D01327 Diflorasone diacetate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2646 Adrenocorticotropic hormones
D01327 Diflorasone diacetate (JP18/USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00418 Diflorasone
D01327 Diflorasone diacetate
Dermatological agent
DG03243 Atopic dermatitis agent
D01327 Diflorasone diacetate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D01327 Diflorasone diacetate
Dermatological agent
DG03243 Atopic dermatitis agent
D01327 Diflorasone diacetate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D01327 Diflorasone diacetate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01327 Diflorasone diacetate
Topical steroids potency [br08317.html]
Classification in the USA
D01327
Classification in Japan
D01327
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00418 Diflorasone
|
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| Other DBs |
|
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| KCF data |
ATOM 35
1 C1z C 32.0564 -14.3706
2 C1z C 30.9003 -15.0167
3 C1y C 33.2015 -15.0507
4 C5a C 32.0791 -12.5453
5 O7a O 34.3069 -13.4125
6 C1y C 30.8775 -16.3486
7 C1x C 29.7439 -14.3479
8 C1a C 30.8889 -13.6621
9 C1x C 33.1844 -16.3826
10 C1b C 30.9227 -11.8538
11 O5a O 33.2580 -11.8878
12 C7a C 35.6502 -13.4125
13 C1y C 29.7211 -17.0006
14 C1y C 28.5932 -14.9941
15 O7a O 29.7496 -12.5227
16 C1a C 36.3134 -12.2505
17 O6a O 36.3248 -14.5802
18 C1z C 28.5818 -16.3317
19 C1x C 29.7211 -18.3268
20 O1a O 27.4370 -14.3365
21 C7a C 28.5818 -11.8482
22 C1z C 27.4257 -16.9892
23 X F 28.5706 -17.6523
24 C1y C 28.5706 -18.9900
25 C1a C 27.4199 -12.5227
26 O6a O 28.5763 -10.4991
27 C2y C 27.4199 -18.3211
28 C2x C 26.2751 -16.3260
29 C1a C 27.4144 -15.6571
30 C2x C 26.2751 -18.9844
31 C2x C 25.1300 -16.9892
32 C5x C 25.1300 -18.3211
33 O5x O 23.9738 -18.9786
34 C1a C 34.5562 -15.0488
35 X F 28.5635 -20.3431
BOND 38
1 1 4 1 #Up
2 1 5 1 #Down
3 2 6 1
4 2 7 1
5 2 8 1 #Up
6 3 9 1
7 4 10 1
8 4 11 2
9 5 12 1
10 6 13 1
11 7 14 1
12 10 15 1
13 12 16 1
14 12 17 2
15 13 18 1
16 13 19 1
17 14 20 1 #Up
18 15 21 1
19 18 22 1
20 18 23 1 #Down
21 19 24 1
22 21 25 1
23 21 26 2
24 22 27 1
25 22 28 1
26 22 29 1 #Up
27 27 30 2
28 28 31 2
29 30 32 1
30 32 33 2
31 6 9 1
32 14 18 1
33 24 27 1
34 31 32 1
35 3 34 1 #Up
36 1 2 1
37 1 3 1
38 24 35 1 #Down
|
|---|
