KEGG   DRUG: Clotiazepam
Entry
D01328                      Drug                                   
Name
Clotiazepam (JP18/INN);
Rize (TN)
Formula
C16H15ClN2OS
Exact mass
318.0594
Mol weight
318.8211
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01567  GABA-A receptor agonist
 DG01914  Anxiolytics, benzodiazepine derivatives
Remark
Therapeutic category: 1179
ATC code: N05BA21
Product: D01328<JP>
Efficacy
Antianxiety, Sedative-hypnotic
Comment
Benzodiazepine derivative (thienodiazepine)
Target
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Structure map
map07030  Anxiolytics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA21 Clotiazepam
      D01328  Clotiazepam (JP18/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01328  Clotiazepam (JP18/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01567  GABA-A receptor agonist
   D01328  Clotiazepam
  DG01914  Anxiolytics, benzodiazepine derivatives
   D01328  Clotiazepam
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D01328  Clotiazepam (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01328  Clotiazepam
  D01328  Clotiazepam tablets
Narcotics and psychotropics in Japan [br08308.html]
 Psychotropics by Control Act Article 2 Table 31 (10 substances)
  D01328
Other DBs
CAS: 33671-46-4
PubChem: 7848391
ChEBI: 31425
LigandBox: D01328
NIKKAJI: J9.292D
KCF data

ATOM        21
            1   C2y C    19.5296  -16.5337
            2   C8y C    18.6872  -15.4238
            3   C8y C    19.0225  -14.0666
            4   N1y N    20.2839  -13.4883
            5   N2x N    20.9358  -16.5589
            6   C5x C    21.5379  -14.1108
            7   C1x C    21.8245  -15.4799
            8   O5x O    22.5823  -13.1761
            9   C8y C    18.8949  -17.7838
            10  C8x C    17.4929  -17.7838
            11  S2x S    17.8354  -13.3283
            12  C8y C    16.7663  -14.2292
            13  C8x C    17.2928  -15.3842
            14  C8x C    16.7927  -18.9967
            15  C8x C    17.4929  -20.2094
            16  C8x C    18.8949  -20.2094
            17  C8y C    19.5951  -18.9967
            18  X   Cl   21.0064  -18.9968
            19  C1b C    15.3659  -14.2292
            20  C1a C    14.6516  -12.9913
            21  C1a C    20.3056  -12.1130
BOND        23
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 2
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     6   8 2
            9     1   9 1
            10    9  10 1
            11    3  11 1
            12   11  12 1
            13   12  13 2
            14    2  13 1
            15   10  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19    9  17 2
            20   17  18 1
            21   12  19 1
            22   19  20 1
            23    4  21 1

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Ontology (6)   
   KEGG BRITE (6)   
Pathway (2)   
   KEGG PATHWAY (2)   
Drug (3)   
   KEGG DGROUP (2)   
   LigandBox (1)   
Chemical substance (4)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   NIKKAJI (1)   
Gene (23)   
   KEGG ORTHOLOGY (7)   
   KEGG GENES (16)   
All databases (38)   

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