KEGG   DRUG: Midecamycin
Entry
D01339                      Drug                                   
Name
Midecamycin (JP18/INN);
Medemycin (TN)
Formula
C41H67NO15
Exact mass
813.4511
Mol weight
813.9684
Structure
Simcomp
Source
Streptomyces mycarofaciens [TAX:1949]
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01876  16-Membered ring macrolide antibiotic
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
  DG01522  CYP3A4 inhibitor
Remark
ATC code: J01FA03
Chemical structure group: DG01903
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
CYP inhibition: CYP3A4 [HSA:1576]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA03 Midecamycin
      D01339  Midecamycin (JP18/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01876  16-Membered ring macrolide antibiotic
    DG01903  Midecamycin
     D01339  Midecamycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG01522  CYP3A4 inhibitor
    DG01903  Midecamycin
     D01339  Midecamycin
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D01339  Midecamycin (JP18/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01339  Midecamycin
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01339
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01876  16-Membered ring macrolide antibiotic
    DG01903  Midecamycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG01522  CYP3A4 inhibitor
    DG01903  Midecamycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG01903  Midecamycin
Other DBs
CAS: 35457-80-8
PubChem: 7848402
ChEBI: 31845
LigandBox: D01339
NIKKAJI: J3.497E
KCF data

ATOM        57
            1   C1y C    26.8994  -21.1901
            2   C1y C    27.9964  -21.8318
            3   O2a O    25.8069  -21.8318
            4   C1y C    26.8994  -19.9298
            5   C1y C    29.1054  -21.1901
            6   N1c N    27.9964  -23.0988
            7   C1y C    24.7156  -22.4624
            8   O2x O    27.9964  -19.2992
            9   C1a C    25.8126  -19.2992
            10  C1y C    29.1054  -19.9298
            11  O1a O    30.2035  -21.8318
            12  C1a C    29.0942  -23.7283
            13  C1a C    26.9051  -23.7283
            14  C1x C    24.7156  -23.7227
            15  O2x O    23.6064  -21.8318
            16  O2a O    31.9933  -16.8787
            17  C1z C    23.6064  -24.3644
            18  C1y C    22.5094  -22.4624
            19  C1y C    28.5430  -13.4567
            20  C1y C    22.5094  -23.7227
            21  C1a C    22.7511  -25.5744
            22  O1a O    24.4965  -25.7321
            23  C1a C    21.4226  -21.8318
            24  C1y C    28.5374  -12.1563
            25  C1y C    27.4228  -14.1154
            26  O7a O    21.4226  -24.3644
            27  C1x C    27.4059  -11.5201
            28  C1b C    29.6231  -11.5144
            29  C1y C    27.4283  -15.4157
            30  O2a O    26.4591  -13.4903
            31  C1y C    27.4059  -10.2432
            32  C4a C    30.7268  -12.1396
            33  C1x C    26.2968  -16.0688
            34  O7a O    28.5319  -16.0453
            35  C1y C    26.2911   -9.6125
            36  C1a C    28.4973   -9.6070
            37  O4a O    31.8181  -11.4977
            38  C7x C    25.1482  -15.4326
            39  C2x C    25.1998  -10.2432
            40  O1a O    26.2911   -8.3531
            41  O7x O    24.0011  -16.0632
            42  O6a O    25.1482  -14.1657
            43  C2x C    25.1998  -11.5201
            44  C1y C    22.8696  -15.3755
            45  C2x C    24.0794  -12.1563
            46  C1x C    22.9229  -14.0359
            47  C1a C    21.7548  -15.9837
            48  C2x C    24.0625  -13.4399
            49  C1a C    26.4489  -12.2292
            50  C7a C    20.3298  -23.7444
            51  C1b C    19.2429  -24.3861
            52  O6a O    20.3172  -22.4894
            53  C1a C    18.1501  -23.7729
            54  C7a C    28.5895  -17.3762
            55  C1b C    27.3552  -18.0339
            56  O6a O    29.6712  -18.0556
            57  C1a C    26.2036  -17.3546
BOND        59
            1     5  11 1 #Down
            2     6  12 1
            3     6  13 1
            4     7  14 1
            5     7  15 1
            6    10  16 1 #Up
            7    14  17 1
            8    15  18 1
            9    19  16 1 #Down
            10   17  20 1
            11   17  21 1 #Down
            12   17  22 1 #Up
            13   18  23 1 #Down
            14   19  24 1
            15   19  25 1
            16   20  26 1 #Up
            17   24  27 1
            18   24  28 1 #Down
            19   25  29 1
            20   25  30 1 #Down
            21   27  31 1
            22   28  32 1
            23   29  33 1
            24   29  34 1 #Down
            25   31  35 1
            26   31  36 1 #Down
            27   32  37 2
            28   33  38 1
            29   35  39 1
            30   35  40 1 #Down
            31   38  41 1
            32   38  42 2
            33   39  43 2
            34   41  44 1
            35   43  45 1
            36   44  46 1
            37   44  47 1 #Down
            38   45  48 2
            39    8  10 1
            40   18  20 1
            41   46  48 1
            42   30  49 1
            43    1   2 1
            44   26  50 1
            45    1   3 1 #Down
            46   50  51 1
            47    1   4 1
            48   50  52 2
            49    2   5 1
            50   51  53 1
            51    2   6 1 #Up
            52    7   3 1 #Up
            53   34  54 1
            54    4   8 1
            55   54  55 1
            56    4   9 1 #Up
            57   54  56 2
            58    5  10 1
            59   55  57 1

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