| Entry |
|
|---|
| Name |
Bevantolol hydrochloride (JAN/USAN);
Calvan (TN);
Vantol (TN) |
|---|
| Formula |
C20H27NO4. HCl
|
|---|
| Exact mass |
381.1707
|
|---|
| Mol weight |
381.8936
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
|
|---|
| Remark |
| Therapeutic category: | 2149 |
|
|---|
| Efficacy |
Antiarrhythmic, Antihypertensive, Vasodilator, alpha1 and beta1-Adrenergic receptor antagonist, Calcium channel blocker |
|---|
| Comment |
anti-anginal
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07214 | beta-Adrenergic receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AB Beta blocking agents, selective
C07AB06 Bevantolol
D01369 Bevantolol hydrochloride (JAN/USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D01369 Bevantolol hydrochloride (JAN/USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
D01369 Bevantolol hydrochloride
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
D01369 Bevantolol hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG03231 Antihypertensive
D01369 Bevantolol hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D01369 Bevantolol hydrochloride (JAN/USAN) <JP>
ADRB1
D01369 Bevantolol hydrochloride (JAN/USAN) <JP>
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D01369 Bevantolol hydrochloride (JAN/USAN) <JP>
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 26
1 O2a O 14.4598 -16.6293
2 C1b C 15.6476 -15.9306
3 C1c C 16.8355 -16.6293
4 C1b C 18.0932 -15.9306
5 O1a O 16.8355 -18.0267
6 N1b N 19.2810 -16.6293
7 C1b C 20.4688 -15.9306
8 C1b C 21.7265 -16.6293
9 C8y C 22.9144 -15.9306
10 C8x C 22.9144 -14.5331
11 C8x C 24.1022 -13.8344
12 C8y C 25.2900 -14.5331
13 C8y C 25.2900 -15.9306
14 C8x C 24.1022 -16.6293
15 O2a O 26.5478 -13.8344
16 C1a C 27.7356 -14.5331
17 O2a O 26.5478 -16.6293
18 C1a C 27.7356 -15.9306
19 C8y C 14.4598 -18.0293
20 C8x C 13.2574 -18.7239
21 C8y C 13.2578 -20.1239
22 C8x C 14.4704 -20.8236
23 C8x C 15.6728 -20.1290
24 C8x C 15.6724 -18.7290
25 C1a C 12.0401 -20.8276
26 X Cl 24.9306 -20.2698
BOND 26
1 6 7 1
2 7 8 1
3 8 9 1
4 1 2 1
5 2 3 1
6 9 10 2
7 10 11 1
8 11 12 2
9 12 13 1
10 13 14 2
11 14 9 1
12 3 4 1
13 12 15 1
14 15 16 1
15 3 5 1
16 13 17 1
17 17 18 1
18 4 6 1
19 1 19 1
20 19 20 2
21 20 21 1
22 21 22 2
23 22 23 1
24 23 24 2
25 19 24 1
26 21 25 1
|
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