| Entry |
|
|---|
| Name |
Zopiclone (JP18/INN);
Amoban (TN);
Zopiclone (TN) |
|---|
| Formula |
C17H17ClN6O3
|
|---|
| Exact mass |
388.1051
|
|---|
| Mol weight |
388.8083
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01836 Non-benzodiazepine sedative-hypnotics
DG03202 Hypnotic
DG01567 GABA-A receptor agonist
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 1129 |
|
|---|
| Efficacy |
Sedative-hypnotic |
|---|
| Comment |
Non-benzodiazepines (cyclopyrrolones)
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]; CYP2C8 [HSA: 1558]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07230 | GABA-A receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05C HYPNOTICS AND SEDATIVES
N05CF Benzodiazepine related drugs
N05CF01 Zopiclone
D01372 Zopiclone (JP18/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
112 Hypnotics and sedatives, anxiolytics
1129 Others
D01372 Zopiclone (JP18/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01836 Non-benzodiazepine sedative-hypnotics
D01372 Zopiclone
DG03202 Hypnotic
D01372 Zopiclone
DG01567 GABA-A receptor agonist
D01372 Zopiclone
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
D01372 Zopiclone
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D01372 Zopiclone
Drug classes [BR:br08332]
Neuropsychiatric agent
DG03202 Hypnotic
D01372 Zopiclone
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D01372 Zopiclone (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01372 Zopiclone
D01372 Zopiclone tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01372
Narcotics and psychotropics in Japan [br08308.html]
Psychotropics by Cabinet order Article 3 (78 substances)
D01372
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 27
1 C8x C 13.5800 -12.3200
2 C8x C 13.5800 -13.7200
3 N5x N 14.7700 -14.4200
4 C8y C 16.0300 -13.7200
5 C8y C 16.0300 -12.3200
6 N5x N 14.7700 -11.6200
7 C1y C 17.3600 -14.1400
8 N1y N 18.2000 -13.0200
9 C5x C 17.3600 -11.9000
10 C8y C 19.5300 -13.0200
11 N5x N 20.2300 -11.8300
12 C8x C 21.6300 -11.8300
13 C8y C 22.3300 -13.0200
14 C8x C 21.6300 -14.2100
15 C8x C 20.2300 -14.2100
16 O5x O 17.7800 -10.5700
17 X Cl 23.7300 -13.0200
18 O7a O 17.3600 -15.5400
19 C7a C 18.5500 -16.2400
20 N1y N 18.5500 -17.6400
21 O6a O 19.8100 -15.5400
22 C1x C 17.3600 -18.3400
23 C1x C 17.3600 -19.7400
24 N1y N 18.5500 -20.4400
25 C1x C 19.8100 -19.7400
26 C1x C 19.8100 -18.3400
27 C1a C 18.5500 -21.8400
BOND 30
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 5 9 1
11 8 10 1
12 10 11 2
13 11 12 1
14 12 13 2
15 13 14 1
16 14 15 2
17 10 15 1
18 9 16 2
19 13 17 1
20 18 19 1
21 19 20 1
22 19 21 2
23 7 18 1
24 20 22 1
25 22 23 1
26 23 24 1
27 24 25 1
28 25 26 1
29 20 26 1
30 24 27 1
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