KEGG   DRUG: Isoproterenol hydrochloride
Entry
D01390                      Drug                                   
Name
Isoproterenol hydrochloride (USP);
dl-Isoprenaline hydrochloride (JAN);
Isuprel (TN);
Proternol-S (TN)
Product
  Generic
ISOPROTERENOL (Cipla USA), ISOPROTERENOL HYDROCHLORIDE (Amneal Pharmaceuticals LLC), ISOPROTERENOL HYDROCHLORIDE (Amphastar Pharmaceuticals), ISOPROTERENOL HYDROCHLORIDE (Amring Pharmaceuticals), ISOPROTERENOL HYDROCHLORIDE (Armas Pharmaceuticals), ISOPROTERENOL HYDROCHLORIDE (Athenex Pharmaceutical Division), ISOPROTERENOL HYDROCHLORIDE (Eugia US LLC), ISOPROTERENOL HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), ISOPROTERENOL HYDROCHLORIDE (KVK-Tech), ISOPROTERENOL HYDROCHLORIDE (Micro Labs Limited), ISOPROTERENOL HYDROCHLORIDE (Nexus Pharmaceuticals)
Formula
C11H17NO3. HCl
Exact mass
247.0975
Mol weight
247.7185
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
Metabolizing enzyme substrate
 DG01592  COMT substrate
Remark
Therapeutic category: 1339 2119 2252
ATC code: C01CA02 R03AB02 R03CB01
Chemical structure group: DG00211
Product (DG00211): D01390<JP/US> D02150<JP>
Efficacy
Antivertigo, Cardiotonic, Bronchodilator, beta-Adrenergic receptor agonist
Comment
Catecholamine derivative
Target
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
Metabolism
Enzyme: COMT [HSA:1312]
Interaction
Structure map
map07214  beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA02 Isoprenaline
      D01390  Isoproterenol hydrochloride (USP) <JP/US>
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AB Non-selective beta-adrenoreceptor agonists
     R03AB02 Isoprenaline
      D01390  Isoproterenol hydrochloride (USP) <JP/US>
   R03C ADRENERGICS FOR SYSTEMIC USE
    R03CB Non-selective beta-adrenoreceptor agonists
     R03CB01 Isoprenaline
      D01390  Isoproterenol hydrochloride (USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   133  Vertigo agents
    1339  Others
     D01390  Isoproterenol hydrochloride (USP); dl-Isoprenaline hydrochloride (JAN)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   211  Cardiotonics
    2119  Others
     D01390  Isoproterenol hydrochloride (USP); dl-Isoprenaline hydrochloride (JAN)
  22  Respiratory organ agents
   225  Bronchodilators
    2252  Isoprenalines
     D01390  Isoproterenol hydrochloride (USP); dl-Isoprenaline hydrochloride (JAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01703  Cardiotonic
   DG01699  Catecholamine cardiotonic
    DG00211  Isoprenaline
     D01390  Isoproterenol hydrochloride
  DG01456  Adrenergic receptor agonist
   DG01455  beta-Adrenergic receptor agonist
    DG00211  Isoprenaline
     D01390  Isoproterenol hydrochloride
  DG01951  Catecholamine adrenergic receptor agonist
   DG00211  Isoprenaline
    D01390  Isoproterenol hydrochloride
 Metabolizing enzyme substrate
  DG01592  COMT substrate
   DG00211  Isoprenaline
    D01390  Isoproterenol hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB
     D01390  Isoproterenol hydrochloride (USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01390
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01703  Cardiotonic
   DG01699  Catecholamine cardiotonic
    DG00211  Isoprenaline
  DG01456  Adrenergic receptor agonist
   DG01455  beta-Adrenergic receptor agonist
    DG00211  Isoprenaline
  DG01951  Catecholamine adrenergic receptor agonist
   DG00211  Isoprenaline
 Metabolizing enzyme substrate
  DG01592  COMT substrate
   DG00211  Isoprenaline
Other DBs
CAS: 51-30-9
PubChem: 7848453
ChEBI: 31453
LigandBox: D01390
NIKKAJI: J231.236K
KCF data

ATOM        16
            1   X   Cl   32.4563  -16.2547
            2   C8y C    22.3615  -15.8607
            3   C8x C    21.1737  -15.0920
            4   C8x C    22.3615  -17.2582
            5   C8y C    19.9159  -15.7908
            6   C8x C    21.1038  -17.8870
            7   C8y C    19.9159  -17.1184
            8   O1a O    18.7280  -15.0222
            9   O1a O    18.7280  -17.8172
            10  C1c C    23.6193  -15.1619
            11  C1b C    24.8072  -15.8607
            12  N1b N    25.9950  -15.1619
            13  C1c C    27.2528  -15.8607
            14  C1a C    28.4407  -15.1619
            15  O1a O    23.6193  -13.7644
            16  C1a C    27.2528  -17.2582
BOND        15
            1     2   3 1
            2     2   4 2
            3     3   5 2
            4     4   6 1
            5     5   7 1
            6     5   8 1
            7     7   9 1
            8     6   7 2
            9     2  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   10  15 1
            15   13  16 1

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