| Entry |
|
|---|
| Name |
Fentanyl citrate (JP18/USP);
Abstral (TN);
Fentora (TN);
Lazanda (TN);
Oralet (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C22H28N2O. C6H8O7
|
|---|
| Exact mass |
528.2472
|
|---|
| Mol weight |
528.594
|
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| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG02030 Anesthetics
DG02027 General anesthetics
DG02026 Opioid anesthetics
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
Analgesic
DG01984 Opioid analgesics
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 8219 |
| Product (DG00791): | D00320<JP/US> D01399<JP/US> |
|
|---|
| Efficacy |
Analgesic (narcotic), Opioid receptor agonist |
|---|
| Comment |
Phenylpiperidine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N01 ANESTHETICS
N01A ANESTHETICS, GENERAL
N01AH Opioid anesthetics
N01AH01 Fentanyl
D01399 Fentanyl citrate (JP18/USP) <JP/US>
N02 ANALGESICS
N02A OPIOIDS
N02AB Phenylpiperidine derivatives
N02AB03 Fentanyl
D01399 Fentanyl citrate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Analgesics
Opioid Analgesics, Long-acting
Fentanyl
D01399 Fentanyl citrate (JP18/USP)
Opioid Analgesics, Short-acting
Fentanyl
D01399 Fentanyl citrate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
8 Narcotics
82 Non-alkaloidal narcotics
821 Synthetic narcotics
8219 Others
D01399 Fentanyl citrate (JP18/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG02030 Anesthetics
DG02027 General anesthetics
DG02026 Opioid anesthetics
DG00791 Fentanyl
D01399 Fentanyl citrate
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00791 Fentanyl
D01399 Fentanyl citrate
Analgesic
DG01984 Opioid analgesics
DG00791 Fentanyl
D01399 Fentanyl citrate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00791 Fentanyl
D01399 Fentanyl citrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D01399 Fentanyl citrate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01399 Fentanyl citrate
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D01399
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01399
Drug groups [BR:br08330]
Neuropsychiatric agent
DG02030 Anesthetics
DG02027 General anesthetics
DG02026 Opioid anesthetics
DG00791 Fentanyl
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00791 Fentanyl
Analgesic
DG01984 Opioid analgesics
DG00791 Fentanyl
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00791 Fentanyl
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 38
1 C1d C 39.8723 -15.9084
2 C1b C 38.6652 -16.6023
3 C1b C 41.0794 -16.5964
4 C6a C 40.5604 -14.6954
5 O1a O 39.1666 -14.6954
6 C6a C 37.4638 -15.9142
7 C6a C 41.0677 -17.9902
8 O6a O 39.8547 -13.4825
9 O6a O 41.9600 -14.6954
10 O6a O 36.2569 -16.6140
11 O6a O 37.4522 -14.5205
12 O6a O 42.2749 -18.6900
13 O6a O 39.8547 -18.6840
14 N1c N 25.4800 -15.0500
15 C1y C 26.7400 -15.7500
16 C8y C 24.2900 -15.7500
17 C5a C 25.4800 -13.6500
18 C1x C 26.7400 -17.1500
19 C1x C 27.9300 -15.0500
20 C8x C 23.1000 -15.0500
21 C8x C 24.2900 -17.1500
22 C1b C 26.7400 -12.9500
23 O5a O 24.2900 -12.9500
24 C1x C 27.9300 -17.8500
25 C1x C 29.1200 -15.7500
26 C8x C 21.8400 -15.7500
27 C8x C 23.0300 -17.8500
28 C1a C 27.9300 -13.6500
29 N1y N 29.1200 -17.1500
30 C8x C 21.8400 -17.0800
31 C1b C 30.3800 -17.8500
32 C1b C 31.5700 -17.1500
33 C8y C 32.7600 -17.8500
34 C8x C 32.7600 -19.2500
35 C8x C 34.0200 -17.1500
36 C8x C 34.0200 -19.9500
37 C8x C 35.2100 -17.8500
38 C8x C 35.2100 -19.2500
BOND 39
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1
5 2 6 1
6 3 7 1
7 4 8 1
8 4 9 2
9 6 10 1
10 6 11 2
11 7 12 1
12 7 13 2
13 14 15 1
14 14 16 1
15 14 17 1
16 15 18 1
17 15 19 1
18 16 20 2
19 16 21 1
20 17 22 1
21 17 23 2
22 18 24 1
23 19 25 1
24 20 26 1
25 21 27 2
26 22 28 1
27 24 29 1
28 26 30 2
29 29 31 1
30 31 32 1
31 32 33 1
32 33 34 1
33 33 35 2
34 34 36 2
35 35 37 1
36 36 38 1
37 25 29 1
38 27 30 1
39 37 38 2
|
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