| Entry |
|
|---|
| Name |
Fosfluconazole (JAN/INN);
Prodif (TN) |
|---|
| Formula |
C13H13F2N6O4P
|
|---|
| Exact mass |
386.0704
|
|---|
| Mol weight |
386.2507
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antifungal
DG01523 Triazole antifungal
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG01933 CYP2C19 inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
|
|---|
| Remark |
| Therapeutic category: | 6290 |
| Product (DG00371): | D00322<JP/US> D01429<JP> |
|
|---|
| Efficacy |
Antifungal, Ergosterol biosynthesis inhibitor |
|---|
| Comment |
Triazole derivative
Active form of prodrug: Fluconazole [DR: D00322]
|
|---|
| Target |
sterol 14alpha-demethylase [KO: K05917] |
|---|
| Pathway |
|
|---|
| Interaction |
CYP inhibition: CYP2C19 [HSA: 1557], CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576]
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
D01A ANTIFUNGALS FOR TOPICAL USE
D01AC Imidazole and triazole derivatives
D01AC15 Fluconazole
D01429 Fosfluconazole (JAN/INN) <JP>
J ANTIINFECTIVES FOR SYSTEMIC USE
J02 ANTIMYCOTICS FOR SYSTEMIC USE
J02A ANTIMYCOTICS FOR SYSTEMIC USE
J02AC Triazole and tetrazole derivatives
J02AC01 Fluconazole
D01429 Fosfluconazole (JAN/INN) <JP>
USP drug classification [BR:br08302]
Antifungals
Fluconazole
D01429 Fosfluconazole (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
629 Miscellaneous
6290 Miscellaneous
D01429 Fosfluconazole (JAN/INN)
Drug groups [BR:br08330]
Antifungal
DG01523 Triazole antifungal
DG00371 Fluconazole
D01429 Fosfluconazole
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG00371 Fluconazole
D01429 Fosfluconazole
DG01933 CYP2C19 inhibitor
DG00371 Fluconazole
D01429 Fosfluconazole
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00371 Fluconazole
D01429 Fosfluconazole
Drug classes [BR:br08332]
Antifungal
DG01523 Triazole antifungal
D01429 Fosfluconazole
Antimicrobials [BR:br08307]
Antifungals
Ergosterol biosynthesis inhibitor
Triazole
D01429 Fosfluconazole (JAN/INN) <JP>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D01429
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01429
Prodrugs [br08324.html]
D01429
Drug groups [BR:br08330]
Antifungal
DG01523 Triazole antifungal
DG00371 Fluconazole
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG00371 Fluconazole
DG01933 CYP2C19 inhibitor
DG00371 Fluconazole
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00371 Fluconazole
Antimicrobials abbreviations [BR:br08327]
Antifungals
Ergosterol biosynthesis inhibitor
Triazole
DG00371 Fluconazole
Prodrugs [br08324.html]
DG00371
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 26
1 C8x C 30.1700 -12.4600
2 C8x C 30.1700 -13.8600
3 C8y C 31.2900 -14.5600
4 C8y C 32.4800 -13.8600
5 C8x C 32.4800 -12.4600
6 C8y C 31.2900 -11.7600
7 X F 31.2900 -10.4300
8 X F 33.7400 -14.5600
9 C1d C 31.2900 -16.7300
10 C1b C 30.1000 -17.4300
11 C1b C 32.4800 -17.3600
12 N4y N 28.9800 -16.7300
13 N4y N 33.6700 -16.7300
14 C8x C 28.9800 -15.3300
15 C8x C 33.6700 -15.3300
16 N5x N 27.6500 -14.9100
17 C8x C 26.8100 -16.0300
18 N5x N 27.6500 -17.1500
19 N5x N 34.9300 -17.1500
20 C8x C 35.7700 -16.0300
21 N5x N 34.9300 -14.9100
22 O2b O 31.2900 -18.0600
23 P1b P 31.2900 -19.4600
24 O1c O 31.2900 -20.7900
25 O1c O 32.6900 -19.4600
26 O1c O 29.9600 -19.4600
BOND 28
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 6 7 1
8 4 8 1
9 3 9 1
10 9 10 1
11 9 11 1
12 10 12 1
13 11 13 1
14 12 14 1
15 13 15 1
16 14 16 2
17 16 17 1
18 17 18 2
19 12 18 1
20 13 19 1
21 19 20 2
22 20 21 1
23 15 21 2
24 9 22 1
25 22 23 1
26 23 24 2
27 23 25 1
28 23 26 1
|
|---|
