| Entry |
|
|---|
| Name |
Isoniazid calcium pyruvinate (JAN);
Pyruvic acid calcium isoniazid |
|---|
| Formula |
(C9H8N3O3)2. Ca
|
|---|
| Exact mass |
452.0757
|
|---|
| Mol weight |
452.4342
|
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| Structure |
|
|---|
| Class |
Antibacterial
DG01966 Antitubercular
Neuropsychiatric agent
DG01568 MAO inhibitor
DG01519 Non-selective monoamine oxidase inhibitor
|
|---|
| Remark |
| Product (DG00642): | D00346<JP/US> D02002<JP> |
|
|---|
| Efficacy |
Antibacterial (tuberculostatic) |
|---|
| Comment |
Hydrazide derivative
|
|---|
| Target |
enoyl-[acyl-carrier-protein] reductase (NADH) [KO: K11611] |
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J04 ANTIMYCOBACTERIALS
J04A DRUGS FOR TREATMENT OF TUBERCULOSIS
J04AC Hydrazides
J04AC01 Isoniazid
D01501 Isoniazid calcium pyruvinate (JAN)
Drug groups [BR:br08330]
Antibacterial
DG01966 Antitubercular
DG00642 Isoniazid
D01501 Isoniazid calcium pyruvinate
Neuropsychiatric agent
DG01568 MAO inhibitor
DG01519 Non-selective monoamine oxidase inhibitor
DG00642 Isoniazid
D01501 Isoniazid calcium pyruvinate
Antimicrobials [BR:br08307]
Antibacterials
Other antibacterials
Mycolic acid biosynthesis inhibitor
D01501 Isoniazid calcium pyruvinate (JAN)
Drug groups [BR:br08330]
Antibacterial
DG01966 Antitubercular
DG00642 Isoniazid
Neuropsychiatric agent
DG01568 MAO inhibitor
DG01519 Non-selective monoamine oxidase inhibitor
DG00642 Isoniazid
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Other antibacterials
Mycolic acid biosynthesis inhibitor
DG00642 Isoniazid
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 31
1 C8y C 28.2548 -14.0547
2 C5a C 29.4683 -14.7549
3 C8x C 27.0469 -14.7549
4 C8x C 28.2548 -12.6543
5 N1b N 30.6821 -14.0547
6 O5a O 29.4683 -16.1553
7 C8x C 25.8275 -14.0547
8 C8x C 27.0469 -11.9484
9 N2b N 31.9016 -14.7549
10 N5x N 25.8275 -12.6543
11 C2c C 33.1089 -14.0540
12 C6a C 34.3196 -14.7492
13 C1a C 33.1055 -12.6581
14 O6a O 34.3228 -16.1451
15 O6a O 35.5269 -14.0483 #-
16 Z Ca 38.0419 -14.0341 #2+
17 C8y C 28.2548 -14.0547
18 C8x C 27.0469 -14.7549
19 C8x C 25.8275 -14.0547
20 N5x N 25.8275 -12.6543
21 C8x C 27.0469 -11.9484
22 C8x C 28.2548 -12.6543
23 C5a C 29.4683 -14.7549
24 N1b N 30.6821 -14.0547
25 N2b N 31.9016 -14.7549
26 C2c C 33.1089 -14.0540
27 C6a C 34.3196 -14.7492
28 O6a O 35.5269 -14.0483 #-
29 O6a O 34.3228 -16.1451
30 C1a C 33.1055 -12.6581
31 O5a O 29.4683 -16.1553
BOND 30
1 1 3 2
2 12 15 1
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 1
7 4 8 2
8 5 9 1
9 7 10 2
10 8 10 1
11 9 11 2
12 11 12 1
13 11 13 1
14 1 2 1
15 12 14 2
16 17 18 2
17 27 28 1
18 17 22 1
19 23 24 1
20 23 31 2
21 18 19 1
22 22 21 2
23 24 25 1
24 19 20 2
25 21 20 1
26 25 26 2
27 26 27 1
28 26 30 1
29 17 23 1
30 27 29 2
BRACKET 1 25.3400 -16.7300 25.3400 -11.4100
1 36.4000 -11.4100 36.4000 -16.7300
1 2
ORIGINAL 1 1 3 7 10 8 4 2 5 9 11 12 15 14 13 6
REPEAT 1 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31
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