| Entry |
|
|---|
| Name |
Etizolam (JP18/INN);
Sedekopan (TN) |
|---|
| Formula |
C17H15ClN4S
|
|---|
| Exact mass |
342.0706
|
|---|
| Mol weight |
342.8458
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG03202 Hypnotic
DG01567 GABA-A receptor agonist
DG01914 Anxiolytics, benzodiazepine derivatives
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 1179 |
|
|---|
| Efficacy |
Antianxiety, Minor tranquilizer, Sedative-hypnotic |
|---|
| Comment |
Benzodiazepine derivative (thienodiazepine)
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07230 | GABA-A receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05B ANXIOLYTICS
N05BA Benzodiazepine derivatives
N05BA19 Etizolam
D01514 Etizolam (JP18/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D01514 Etizolam (JP18/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03202 Hypnotic
D01514 Etizolam
DG01567 GABA-A receptor agonist
D01514 Etizolam
DG01914 Anxiolytics, benzodiazepine derivatives
D01514 Etizolam
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
D01514 Etizolam
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D01514 Etizolam
Drug classes [BR:br08332]
Neuropsychiatric agent
DG03202 Hypnotic
D01514 Etizolam
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D01514 Etizolam (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01514 Etizolam
D01514 Etizolam tablets
D01514 Etizolam fine granules
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01514
Narcotics and psychotropics in Japan [br08308.html]
Psychotropics by Cabinet order Article 3 (78 substances)
D01514
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 23
1 C2y C 32.3910 -16.5222
2 C8y C 31.5532 -15.4102
3 C8y C 31.8931 -14.0554
4 N4y N 33.1554 -13.4822
5 N2x N 33.7958 -16.5524
6 C8y C 34.4061 -14.1085
7 C1x C 34.6877 -15.4776
8 S2x S 30.7095 -13.3135
9 C8y C 29.6383 -14.2100
10 C8x C 30.1596 -15.3659
11 C8y C 31.6701 -17.7110
12 C8x C 30.2798 -17.7110
13 C8x C 29.5847 -18.9150
14 C8x C 30.2798 -20.1191
15 C8x C 31.6701 -20.1191
16 C8y C 32.3653 -18.9150
17 X Cl 33.7695 -18.9151
18 C1b C 28.4343 -13.5148
19 C1a C 27.2318 -14.2091
20 C8y C 33.1554 -12.0219
21 N5x N 35.3883 -13.1125
22 N5x N 34.7447 -11.8007
23 C1a C 32.1002 -11.1732
BOND 26
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 2
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 1
9 8 9 1
10 9 10 2
11 2 10 1
12 1 11 1
13 11 12 1
14 12 13 2
15 13 14 1
16 14 15 2
17 15 16 1
18 11 16 2
19 16 17 1
20 9 18 1
21 18 19 1
22 4 20 1
23 6 21 2
24 21 22 1
25 22 20 2
26 20 23 1
|
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