| Entry |
|
|---|
| Name |
Dothiepin hydrochloride (USAN);
Dosulepin hydrochloride (JAN);
Dosulepin (TN) |
|---|
| Formula |
C19H21NS. HCl
|
|---|
| Exact mass |
331.1161
|
|---|
| Mol weight |
331.9027
|
|---|
| Structure |
|
|---|
| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG01728 Tricyclic antidepressant
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Therapeutic category: | 1179 |
| Product (DG00940): | D01546<JP> |
|
|---|
| Efficacy |
Antidepressant |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
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| Interaction |
|
|---|
| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AA Non-selective monoamine reuptake inhibitors
N06AA16 Dosulepin
D01546 Dothiepin hydrochloride (USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D01546 Dothiepin hydrochloride (USAN); Dosulepin hydrochloride (JAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00940 Dosulepin
D01546 Dothiepin hydrochloride
DG01728 Tricyclic antidepressant
DG00940 Dosulepin
D01546 Dothiepin hydrochloride
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00940 Dosulepin
D01546 Dothiepin hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
D01546 Dothiepin hydrochloride
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D01546 Dothiepin hydrochloride (USAN) <JP>
SLC6A4 (HTT)
D01546 Dothiepin hydrochloride (USAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01546
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00940 Dosulepin
DG01728 Tricyclic antidepressant
DG00940 Dosulepin
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00940 Dosulepin
|
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| Other DBs |
|
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| KCF data |
ATOM 22
1 C1x C 12.0152 -14.6073
2 C8y C 11.1708 -13.4947
3 C8y C 11.5069 -12.1342
4 C2y C 12.7714 -11.5545
5 S2x S 13.4248 -14.6326
6 C8y C 14.0283 -12.1785
7 C8y C 14.3156 -13.5510
8 C8x C 10.4970 -11.1631
9 C8x C 9.1514 -11.5523
10 C8x C 8.8153 -12.9128
11 C8x C 9.8251 -13.8836
12 C8x C 15.6504 -13.9893
13 C8x C 16.6975 -13.0523
14 C8x C 16.4104 -11.6798
15 C8x C 15.0753 -11.2415
16 C2b C 12.7231 -10.1758
17 C1b C 13.9504 -9.4928
18 C1b C 15.1220 -10.1942
19 N1c N 16.3475 -9.5123
20 C1a C 17.5856 -10.2529
21 C1a C 16.3696 -8.1403
22 X Cl 19.6726 -12.7729
BOND 23
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 4 16 2
19 16 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 19 21 1
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