| Entry |
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| Name |
Acemetacin (JP18/INN);
Rantudil (TN) |
|---|
| Formula |
C21H18ClNO6
|
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| Exact mass |
415.0823
|
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| Mol weight |
415.8237
|
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01899 Anti-inflammatory drug, indoleacetic acid derivatives
|
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| Remark |
| Therapeutic category: | 1145 |
|
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| Efficacy |
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor |
|---|
| Comment |
Indole acetic acid derivative
Active form of prodrug: Indometacin [DR: D00141]
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| Target |
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| Pathway |
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AB Acetic acid derivatives and related substances
M01AB11 Acemetacin
D01582 Acemetacin (JP18/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
114 Antipyretics and analgesics, anti-inflammatory agents
1145 Indomethacins
D01582 Acemetacin (JP18/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01906 Anti-inflammatory drug, acetic acid derivatives
DG01899 Anti-inflammatory drug, indoleacetic acid derivatives
D01582 Acemetacin
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D01582 Acemetacin
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D01582 Acemetacin (JP18/INN) <JP>
PTGS2 (COX2)
D01582 Acemetacin (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01582 Acemetacin
D01582 Acemetacin tablets
D01582 Acemetacin capsules
Prodrugs [br08324.html]
D01582
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| Other DBs |
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| KCF data |
ATOM 29
1 C8y C 21.9781 -18.5377
2 C8y C 21.9712 -20.0070
3 C1a C 23.2493 -20.7477
4 C7a C 24.5276 -18.5570
5 C1b C 23.2564 -17.8092
6 C8y C 19.6486 -19.8923
7 C8y C 19.6486 -18.5426
8 N4y N 20.8227 -20.5704
9 C8x C 18.4682 -20.5587
10 C8x C 18.4682 -17.8584
11 C5a C 20.8020 -21.9407
12 C8x C 17.3130 -19.8923
13 C8y C 17.3130 -18.5426
14 C8y C 19.9721 -22.3753
15 O2a O 16.1585 -17.8830
16 C8x C 18.8103 -21.6822
17 C8x C 19.9398 -23.7251
18 C1a C 14.9963 -18.5614
19 C8x C 17.6276 -22.3322
20 C8x C 18.7702 -24.3744
21 C8y C 17.6107 -23.6731
22 X Cl 16.4534 -24.3307
23 O7a O 25.8057 -17.8216
24 O6a O 24.5276 -20.0193
25 C1b C 27.0775 -18.5680
26 C6a C 28.3627 -17.8398
27 O6a O 29.6345 -18.5792
28 O6a O 28.3690 -16.3649
29 O5a O 21.9719 -22.6604
BOND 31
1 6 8 1
2 6 9 1
3 7 1 1
4 7 10 1
5 8 2 1
6 8 11 1
7 9 12 2
8 10 13 2
9 11 14 1
10 13 15 1
11 14 16 2
12 14 17 1
13 15 18 1
14 16 19 1
15 17 20 2
16 19 21 2
17 21 22 1
18 12 13 1
19 20 21 1
20 4 5 1
21 4 23 1
22 5 1 1
23 4 24 2
24 23 25 1
25 1 2 2
26 25 26 1
27 2 3 1
28 26 27 1
29 6 7 2
30 26 28 2
31 11 29 2
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