KEGG   DRUG: Dexamethasone palmitate
Entry
D01615                      Drug                                   
Name
Dexamethasone palmitate (JAN);
Dexamethasone 21-palmitate;
Limethason (TN)
Formula
C38H59FO6
Exact mass
630.4296
Mol weight
630.8699
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG02853  CYP3A/CYP3A4 inducer
  DG01635  CYP3A4 inducer
Remark
Therapeutic category: 2454
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Antirheumatic, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D01615  Dexamethasone palmitate (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2454  Fluorinated adrenocorticotropic hormones
     D01615  Dexamethasone palmitate (JAN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00011  Dexamethasone
     D01615  Dexamethasone palmitate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00011  Dexamethasone
     D01615  Dexamethasone palmitate
 Metabolizing enzyme inducer
  DG02853  CYP3A/CYP3A4 inducer
   DG01635  CYP3A4 inducer
    DG00011  Dexamethasone
     D01615  Dexamethasone palmitate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D01615  Dexamethasone palmitate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01615  Dexamethasone palmitate (JAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01615
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00011  Dexamethasone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00011  Dexamethasone
 Metabolizing enzyme inducer
  DG02853  CYP3A/CYP3A4 inducer
   DG01635  CYP3A4 inducer
    DG00011  Dexamethasone
Other DBs
CAS: 14899-36-6
PubChem: 7848678
ChEBI: 31471
LigandBox: D01615
NIKKAJI: J265.157B
KCF data

ATOM        45
            1   C1z C    11.5428  -18.6613
            2   C1y C    12.6894  -19.3399
            3   C1z C    10.3788  -19.3282
            4   C1y C    11.5545  -17.3219
            5   X   F    11.5136  -19.9425
            6   C1y C    13.8535  -18.6790
            7   C1x C    12.6894  -20.6736
            8   C2y C    10.3730  -20.6619
            9   C2x C     9.2263  -18.6556
            10  C1a C    10.3670  -17.8307
            11  C1x C    12.7128  -16.6667
            12  O1a O    10.3962  -16.6491
            13  C1z C    13.8653  -17.3393
            14  C1x C    16.1525  -18.7081
            15  C1x C    11.5311  -21.3406
            16  C2x C     9.2263  -21.3348
            17  C2x C     8.0622  -19.3282
            18  C1z C    15.0234  -16.6959
            19  C1a C    13.8944  -16.0113
            20  C1y C    16.1700  -17.3685
            21  C5x C     8.0622  -20.6619
            22  C5a C    15.0351  -14.7947
            23  O1a O    16.6673  -15.7423
            24  C1a C    17.3401  -16.7133
            25  O5x O     6.9039  -21.3348
            26  C1b C    16.1875  -14.1043
            27  O5a O    13.8944  -14.1863
            28  O7a O    17.3516  -14.7537
            29  C7a C    18.5545  -14.0501
            30  C1b C    19.7633  -14.7498
            31  C1b C    20.9720  -14.0501
            32  C1b C    22.1807  -14.7498
            33  C1b C    23.3894  -14.0501
            34  C1b C    24.5981  -14.7498
            35  C1b C    25.8068  -14.0501
            36  C1b C    27.0155  -14.7498
            37  C1b C    28.2242  -14.0501
            38  C1b C    29.4330  -14.7498
            39  C1b C    30.6417  -14.0501
            40  C1b C    31.8504  -14.7498
            41  C1b C    33.0591  -14.0501
            42  C1b C    34.2678  -14.7498
            43  C1b C    35.4765  -14.0501
            44  C1a C    36.6852  -14.7498
            45  O6a O    18.5772  -12.6721
BOND        48
            1    18  23 1 #Down
            2    20  24 1 #Down
            3    21  25 2
            4    22  26 1
            5    22  27 2
            6    26  28 1
            7     8  15 1
            8    11  13 1
            9    17  21 1
            10   18  20 1
            11    1   2 1
            12    1   3 1
            13    1   4 1
            14    1   5 1 #Down
            15    2   6 1
            16   28  29 1
            17    2   7 1
            18   29  30 1
            19    3   8 1
            20   30  31 1
            21    3   9 1
            22   31  32 1
            23    3  10 1 #Up
            24   32  33 1
            25    4  11 1
            26   33  34 1
            27    4  12 1 #Up
            28   34  35 1
            29    6  13 1
            30   35  36 1
            31    6  14 1
            32   36  37 1
            33    7  15 1
            34   37  38 1
            35    8  16 2
            36   38  39 1
            37    9  17 2
            38   39  40 1
            39   13  18 1
            40   40  41 1
            41   13  19 1 #Up
            42   41  42 1
            43   14  20 1
            44   42  43 1
            45   16  21 1
            46   43  44 1
            47   18  22 1 #Up
            48   29  45 2

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