KEGG   DRUG: Hydrocortisone butyrate
Entry
D01619                      Drug                                   
Name
Hydrocortisone butyrate (JP18/USP);
Locoid (TN)
Product
HYDROCORTISONE BUTYRATE (Oceanside Pharmaceuticals), LOCOID (Bausch Health US), LOCOID LIPOCREAM (Bausch Health US)
  Generic
HYDROCORTISONE BUTYRATE (Glenmark Pharmaceuticals), HYDROCORTISONE BUTYRATE (Lupin Pharmaceuticals), HYDROCORTISONE BUTYRATE (Oceanside Pharmaceuticals), HYDROCORTISONE BUTYRATE (Oceanside Pharmaceuticals), HYDROCORTISONE BUTYRATE (Taro Pharmaceuticals U.S.A.), HYDROCORTISONE BUTYRATE (The J. Molner Company LLC)
Formula
C25H36O6
Exact mass
432.2512
Mol weight
432.5497
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Dermatological agent
 DG03243  Atopic dermatitis agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Therapeutic category: 2646
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07AB02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Atopic dermatitis [DS:H01358]
Seborrheic dermatitis [DS:H01652]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
    D07AB Corticosteroids, moderately potent (group II)
     D07AB02 Hydrocortisone butyrate
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Hydrocortisone
     D01619  Hydrocortisone butyrate (JP18/USP)
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D01619  Hydrocortisone butyrate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01619  Hydrocortisone butyrate (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D01619  Hydrocortisone butyrate (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone butyrate
    D01619  Hydrocortisone butyrate (JP18/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone butyrate
    D01619  Hydrocortisone butyrate (JP18/USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
     D01619  Hydrocortisone butyrate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01619  Hydrocortisone butyrate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
    D01619  Hydrocortisone butyrate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D01619  Hydrocortisone butyrate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01619  Hydrocortisone butyrate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01619  Hydrocortisone butyrate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01619
Topical steroids potency [br08317.html]
 Classification in the USA
  D01619
 Classification in Japan
  D01619
Rx-to-OTC switch list in Japan [br08314.html]
 D01619
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
Other DBs
CAS: 13609-67-1
PubChem: 7848682
ChEBI: 31674
LigandBox: D01619
NIKKAJI: J8.130B
KCF data

ATOM        31
            1   C1z C    23.4455  -15.4741
            2   C1y C    23.4632  -16.8359
            3   C1z C    24.6253  -14.7814
            4   C1x C    22.2892  -14.7991
            5   C1y C    22.3069  -17.5227
            6   C1x C    25.8286  -16.8824
            7   C1x C    25.8169  -15.4506
            8   C5a C    24.6136  -13.4138
            9   O7a O    25.9754  -14.4939
            10  C1y C    21.0976  -15.4918
            11  C1y C    21.1036  -16.8476
            12  C1x C    22.3069  -18.8845
            13  C1b C    25.8581  -12.7564
            14  O5a O    23.3868  -12.7035
            15  O1a O    19.8767  -14.7874
            16  C1z C    19.9472  -17.5285
            17  C1x C    21.1270  -19.5712
            18  O1a O    27.0672  -13.5018
            19  C2y C    19.9590  -18.8963
            20  C1x C    18.7614  -16.8594
            21  C2x C    18.7732  -19.5889
            22  C1x C    17.5758  -17.5402
            23  C5x C    17.5581  -18.9783
            24  O5x O    16.3665  -19.6182
            25  C7a C    27.1852  -15.1923
            26  C1b C    28.3980  -14.4902
            27  C1b C    29.6109  -15.1923
            28  C1a C    30.8237  -14.4902
            29  O6a O    27.1860  -16.5967
            30  C1a C    23.3905  -14.2074
            31  C1a C    19.9850  -16.2632
BOND        34
            1     3   8 1 #Up
            2     3   9 1 #Down
            3     4  10 1
            4     5  11 1
            5     5  12 1
            6     8  13 1
            7     8  14 2
            8    10  15 1 #Up
            9    11  16 1
            10   12  17 1
            11   13  18 1
            12   16  19 1
            13   16  20 1
            14   19  21 2
            15   20  22 1
            16   21  23 1
            17   23  24 2
            18    6   7 1
            19   10  11 1
            20   17  19 1
            21   22  23 1
            22    9  25 1
            23    1   2 1
            24   25  26 1
            25    1   3 1
            26   26  27 1
            27    1   4 1
            28   27  28 1
            29    2   5 1
            30   25  29 2
            31    2   6 1
            32    1  30 1 #Up
            33    3   7 1
            34   16  31 1 #Up

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