KEGG   DRUG: Cefditoren pivoxil
Entry
D01628                      Drug                                   
Name
Cefditoren pivoxil (JP18/USAN);
Meiact (TN);
Spectracef (TN)
Formula
C25H28N6O7S3
Exact mass
620.1182
Mol weight
620.7208
Structure
Simcomp
Class
Antibacterial
 DG01710  beta-Lactam antibiotic
  DG01714  Cephalosporin skeleton group
   DG01488  Cephem
 DG01776  Third-generation cephalosporin
 DG01804  Oxyimino beta-lactam
Remark
Therapeutic category: 6132
ATC code: J01DD16
Chemical structure group: DG00584
Product (DG00584): D01628<JP>
Efficacy
Antibacterial, Cell wall biosynthesis inhibitor
  Disease
Pharyngitis/tonsillitis [DS:H01424]
Comment
Active form of prodrug: Cefditoren [DR:D07639]
Target
penicillin binding protein
  Pathway
ko00550  Peptidoglycan biosynthesis
Interaction
Structure map
map07013  Cephalosporins - oral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DD Third-generation cephalosporins
     J01DD16 Cefditoren
      D01628  Cefditoren pivoxil (JP18/USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   613  Acting mainly on gram-positive and gram-negative bacteria
    6132  Cephem antibioitics
     D01628  Cefditoren pivoxil (JP18/USAN)
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00584  Cefditoren
      D01628  Cefditoren pivoxil
  DG01776  Third-generation cephalosporin
   DG00584  Cefditoren
    D01628  Cefditoren pivoxil
  DG01804  Oxyimino beta-lactam
   DG00584  Cefditoren
    D01628  Cefditoren pivoxil
Drug classes [BR:br08332]
 Antibacterial
  DG01488  Cephem
   D01628  Cefditoren pivoxil
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Third-generation cephalosporin
    D01628  Cefditoren pivoxil (JP18/USAN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01628  Cefditoren pivoxil
  D01628  Cefditoren pivoxil tablets
  D01628  Cefditoren pivoxil fine granules
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01628
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01628
Prodrugs [br08324.html]
 D01628
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00584  Cefditoren
  DG01776  Third-generation cephalosporin
   DG00584  Cefditoren
  DG01804  Oxyimino beta-lactam
   DG00584  Cefditoren
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Third-generation cephalosporin
    DG00584  Cefditoren
Other DBs
CAS: 117467-28-4
PubChem: 7848691
ChEBI: 560555
LigandBox: D01628
NIKKAJI: J419.563I
KCF data

ATOM        41
            1   C1y C    27.8866  -17.6079
            2   N1y N    27.8866  -19.0055
            3   C2y C    29.0746  -19.7043
            4   C2y C    30.2625  -19.0055
            5   C1x C    30.2625  -17.6079
            6   S2x S    29.0746  -16.9091
            7   C1y C    26.4890  -17.6079
            8   C5x C    26.4890  -19.0055
            9   N1b N    25.3010  -16.9091
            10  C5a C    24.0432  -17.6079
            11  O5a O    24.0432  -19.0055
            12  O5x O    25.3010  -19.7043
            13  C2c C    22.8552  -16.9091
            14  C2b C    31.4505  -19.7043
            15  C8y C    21.6673  -17.6079
            16  C2b C    32.7083  -19.0055
            17  C8x C    20.5492  -16.7693
            18  S2x S    19.3612  -17.5380
            19  C8y C    19.7805  -18.9357
            20  N5x N    21.1781  -18.9356
            21  C7a C    29.0746  -21.3814
            22  O7a O    27.8167  -22.0802
            23  O6a O    30.2625  -22.0802
            24  C1b C    26.6288  -21.4513
            25  O7a O    25.5107  -22.0802
            26  C7a C    24.3227  -21.4513
            27  C1d C    23.1348  -22.0802
            28  O6a O    24.3227  -20.0537
            29  C1a C    21.8769  -22.7790
            30  C1a C    22.4360  -20.8922
            31  C1a C    23.8336  -23.3380
            32  N2b N    22.8552  -15.5115
            33  N1a N    18.8721  -20.0537
            34  O2a O    24.0432  -14.8127
            35  C1a C    24.0432  -13.4151
            36  C8y C    32.7083  -17.6079
            37  C8y C    33.8390  -16.7864
            38  N5x N    33.4071  -15.4572
            39  C8x C    32.0095  -15.4572
            40  S2x S    31.5777  -16.7864
            41  C1a C    35.1480  -17.2121
BOND        44
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16   13  15 1
            17   14  16 2
            18   15  17 2
            19   17  18 1
            20   18  19 1
            21   19  20 2
            22   15  20 1
            23    3  21 1
            24   21  22 1
            25   21  23 2
            26   22  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   26  28 2
            31   27  29 1
            32   27  30 1
            33   27  31 1
            34   13  32 2
            35   19  33 1
            36   32  34 1
            37   34  35 1
            38   16  36 1
            39   36  37 2
            40   37  38 1
            41   38  39 2
            42   39  40 1
            43   36  40 1
            44   37  41 1

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Ontology (9)   
   KEGG BRITE (9)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (5)   
   KEGG DISEASE (5)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
All databases (21)   

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