KEGG   DRUG: Dexamethasone dipropionate
Entry
D01632                      Drug                                   
Name
Dexamethasone dipropionate (USAN);
Dexamethasone propionate (JAN);
Hifmeta (TN)
Formula
C28H37FO7
Exact mass
504.2523
Mol weight
504.5876
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Dermatological agent
 DG03243  Atopic dermatitis agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
 DG02853  CYP3A/CYP3A4 inducer
  DG01635  CYP3A4 inducer
Remark
Therapeutic category: 2646
ATC code: A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01
Chemical structure group: DG00011
Product (DG00011): D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP induction: CYP3A4 [HSA:1576]
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D01632  Dexamethasone dipropionate (USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01632  Dexamethasone dipropionate (USAN); Dexamethasone propionate (JAN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00011  Dexamethasone
     D01632  Dexamethasone dipropionate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01632  Dexamethasone dipropionate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00011  Dexamethasone
     D01632  Dexamethasone dipropionate
 Metabolizing enzyme inducer
  DG02853  CYP3A/CYP3A4 inducer
   DG01635  CYP3A4 inducer
    DG00011  Dexamethasone
     D01632  Dexamethasone dipropionate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D01632  Dexamethasone dipropionate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01632  Dexamethasone dipropionate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01632  Dexamethasone dipropionate (USAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01632
Topical steroids potency [br08317.html]
 Classification in Japan
  D01632
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00011  Dexamethasone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00011  Dexamethasone
 Metabolizing enzyme inducer
  DG02853  CYP3A/CYP3A4 inducer
   DG01635  CYP3A4 inducer
    DG00011  Dexamethasone
Other DBs
CAS: 55541-30-5
PubChem: 7848695
ChEBI: 135805 31470
LigandBox: D01632
NIKKAJI: J67.048K
KCF data

ATOM        36
            1   C2x C    18.6476  -17.5714
            2   C5x C    18.6476  -18.9149
            3   C2x C    19.8111  -19.5866
            4   C2y C    20.9746  -18.9149
            5   C1z C    20.9746  -17.5714
            6   C2x C    19.8111  -16.8996
            7   C1x C    22.1382  -19.5866
            8   C1x C    23.3015  -18.9149
            9   C1y C    23.3015  -17.5714
            10  C1z C    22.1382  -16.8996
            11  C1y C    24.4651  -16.8996
            12  C1z C    24.4651  -15.5561
            13  C1x C    23.3015  -14.8844
            14  C1y C    22.1382  -15.5561
            15  C1x C    26.7921  -16.8996
            16  C1y C    26.7921  -15.5561
            17  C1z C    25.6286  -14.8844
            18  C1a C    20.9746  -16.2278
            19  O1a O    20.9765  -14.8856
            20  C1a C    24.4651  -14.2127
            21  C1a C    27.9432  -14.8914
            22  C5a C    25.6286  -13.2051
            23  X   F    22.1382  -18.2431
            24  O7a O    27.3464  -13.7974
            25  O5x O    17.4842  -19.5866
            26  O5a O    26.7961  -12.5311
            27  C1b C    24.4690  -12.5355
            28  O7a O    23.3237  -13.1970
            29  C7a C    28.7322  -13.7974
            30  O6a O    29.4335  -15.0127
            31  C1b C    29.4307  -12.5875
            32  C1a C    30.8165  -12.5875
            33  C7a C    22.1401  -12.5134
            34  C1b C    20.9300  -13.2121
            35  O6a O    22.1409  -11.0989
            36  C1a C    19.7253  -12.5168
BOND        39
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Down
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   27  28 1
            32   24  29 1
            33   29  30 2
            34   29  31 1
            35   31  32 1
            36   28  33 1
            37   33  34 1
            38   33  35 2
            39   34  36 1

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