KEGG   DRUG: Betamethasone dipropionate
Entry
D01637                      Drug                                   
Name
Betamethasone dipropionate (JP18/USP);
Diprolene (TN);
Rinderon-DP (TN);
Sernivo (TN)
Product
BETAMETHASONE DIPROPIONATE (A-S Medication Solutions), BETAMETHASONE DIPROPIONATE (A-S Medication Solutions), BETAMETHASONE DIPROPIONATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), DIPROLENE (Organon LLC), SERNIVO (Primus Pharmaceuticals)
  Generic
BETAMETHASONE DIPROPIONATE (A-S Medication Solutions), BETAMETHASONE DIPROPIONATE (A-S Medication Solutions), BETAMETHASONE DIPROPIONATE (A-S Medication Solutions), BETAMETHASONE DIPROPIONATE (A-S Medication Solutions), BETAMETHASONE DIPROPIONATE (A-S Medication Solutions), BETAMETHASONE DIPROPIONATE (Actavis Pharma), BETAMETHASONE DIPROPIONATE (Actavis Pharma), BETAMETHASONE DIPROPIONATE (Actavis Pharma), BETAMETHASONE DIPROPIONATE (Bryant Ranch Prepack), BETAMETHASONE DIPROPIONATE (Bryant Ranch Prepack), BETAMETHASONE DIPROPIONATE (Bryant Ranch Prepack), BETAMETHASONE DIPROPIONATE (Bryant Ranch Prepack), BETAMETHASONE DIPROPIONATE (Bryant Ranch Prepack), BETAMETHASONE DIPROPIONATE (Bryant Ranch Prepack), BETAMETHASONE DIPROPIONATE (Cosette Pharmaceuticals), BETAMETHASONE DIPROPIONATE (Cosette Pharmaceuticals), BETAMETHASONE DIPROPIONATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), BETAMETHASONE DIPROPIONATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), BETAMETHASONE DIPROPIONATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), BETAMETHASONE DIPROPIONATE (Glenmark Pharmaceuticals), BETAMETHASONE DIPROPIONATE (Golden State Medical Supply), BETAMETHASONE DIPROPIONATE (Lupin Pharmaceuticals), BETAMETHASONE DIPROPIONATE (Northstar Rx LLC.), BETAMETHASONE DIPROPIONATE (NuCare Pharmaceuticals), BETAMETHASONE DIPROPIONATE (Padagis Israel Pharmaceuticals), BETAMETHASONE DIPROPIONATE (Padagis Israel Pharmaceuticals), BETAMETHASONE DIPROPIONATE (Padagis Israel Pharmaceuticals), BETAMETHASONE DIPROPIONATE (Prasco Laboratories), BETAMETHASONE DIPROPIONATE (Preferred Pharmaceuticals), BETAMETHASONE DIPROPIONATE (Preferred Pharmaceuticals), BETAMETHASONE DIPROPIONATE (Proficient Rx LP), BETAMETHASONE DIPROPIONATE (Proficient Rx LP), BETAMETHASONE DIPROPIONATE (REMEDYREPACK), BETAMETHASONE DIPROPIONATE (REMEDYREPACK), BETAMETHASONE DIPROPIONATE (REMEDYREPACK), BETAMETHASONE DIPROPIONATE (RPK Pharmaceuticals), BETAMETHASONE DIPROPIONATE (RPK Pharmaceuticals), BETAMETHASONE DIPROPIONATE (Taro Pharmaceuticals U.S.A.), BETAMETHASONE DIPROPIONATE (Taro Pharmaceuticals U.S.A.), BETAMETHASONE DIPROPIONATE (Taro Pharmaceuticals U.S.A.), BETAMETHASONE DIPROPIONATE (Taro Pharmaceuticals U.S.A.), BETAMETHASONE DIPROPIONATE (Taro Pharmaceuticals U.S.A.), BETAMETHASONE DIPROPIONATE (Taro Pharmaceuticals U.S.A.), BETAMETHASONE DIPROPIONATE (Viona Pharmaceuticals), BETAMETHASONE DIPROPIONATE (Zydus Lifesciences Limited), BETAMETHASONE DIPROPIONATE (Zydus Lifesciences Limited), BETAMETHASONE DIPROPIONATE (Zydus Pharmaceuticals USA), BETAMETHASONE DIPROPIONATE USP, 0.05% (Tasman Pharma), BETAMETHASONE DIPROPIONATE USP, 0.05% (TruPharma LLC)
Formula
C28H37FO7
Exact mass
504.2523
Mol weight
504.5876
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Dermatological agent
 DG03243  Atopic dermatitis agent
Remark
Therapeutic category: 2646
ATC code: A07EA04 C05AA05 D07AC01 D07XC01 H02AB01 R01AD06 R03BA04 S01BA06 S01CB04 S02BA07 S03BA03
Chemical structure group: DG00095
Product (DG00095): D00244<JP> D00972<JP> D01357<JP/US> D01637<JP/US> D02032<JP>
Product (mixture): D10300<US> D10534<JP/US>
Efficacy
Anti-inflammatory, Antipruritic, Glucocorticoid receptor agonist
  Disease
Plaque psoriasis [DS:H01656]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA04 Betamethasone
      D01637  Betamethasone dipropionate (JP18/USP) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA05 Betamethasone
      D01637  Betamethasone dipropionate (JP18/USP) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC01 Betamethasone
      D01637  Betamethasone dipropionate (JP18/USP) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XC Corticosteroids, potent, other combinations
     D07XC01 Betamethasone
      D01637  Betamethasone dipropionate (JP18/USP) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB01 Betamethasone
      D01637  Betamethasone dipropionate (JP18/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD06 Betamethasone
      D01637  Betamethasone dipropionate (JP18/USP) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA04 Betamethasone
      D01637  Betamethasone dipropionate (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA06 Betamethasone
      D01637  Betamethasone dipropionate (JP18/USP) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB04 Betamethasone
      D01637  Betamethasone dipropionate (JP18/USP) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA07 Betamethasone
      D01637  Betamethasone dipropionate (JP18/USP) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA03 Betamethasone
      D01637  Betamethasone dipropionate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, High Potency
    Betamethasone
     D01637  Betamethasone dipropionate (JP18/USP)
   Glucocorticoids, Very High Potency
    Betamethasone
     D01637  Betamethasone dipropionate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01637  Betamethasone dipropionate (JP18/USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00095  Betamethasone
     D01637  Betamethasone dipropionate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01637  Betamethasone dipropionate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D01637  Betamethasone dipropionate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01637  Betamethasone dipropionate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01637  Betamethasone dipropionate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01637  Betamethasone dipropionate
Topical steroids potency [br08317.html]
 Classification in the USA
  D01637
 Classification in Japan
  D01637
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00095  Betamethasone
Other DBs
CAS: 5593-20-4
PubChem: 7848700
ChEBI: 31276
LigandBox: D01637
NIKKAJI: J8.022E
KCF data

ATOM        36
            1   C2x C     6.3892  -13.6510
            2   C5x C     6.3892  -15.0117
            3   C2x C     7.5675  -15.6920
            4   C2y C     8.7459  -15.0117
            5   C1z C     8.7459  -13.6510
            6   C2x C     7.5675  -12.9707
            7   C1x C     9.9243  -15.6920
            8   C1x C    11.1026  -15.0117
            9   C1y C    11.1026  -13.6510
            10  C1z C     9.9243  -12.9707
            11  C1y C    12.2810  -12.9707
            12  C1z C    12.2810  -11.6100
            13  C1x C    11.1026  -10.9297
            14  C1y C     9.9243  -11.6100
            15  C1x C    14.6377  -12.9707
            16  C1y C    14.6377  -11.6100
            17  C1z C    13.4594  -10.9297
            18  C1a C     8.7459  -12.2903
            19  O1a O     8.7479  -10.9309
            20  C1a C    12.2810  -10.2494
            21  C1a C    15.8036  -10.9368
            22  C5a C    13.4594   -9.2289
            23  X   F     9.9243  -14.3313
            24  O7a O    15.2677   -9.8294
            25  O5x O     5.2109  -15.6920
            26  O5a O    14.6417   -8.5463
            27  C1b C    12.2849   -8.5508
            28  O7a O    11.1250   -9.2207
            29  C7a C     9.9245   -8.5280
            30  C1b C     8.7188   -9.2247
            31  C1a C     7.5362   -8.5423
            32  O6a O     9.9243   -7.1401
            33  C7a C    16.6677   -9.8294
            34  O6a O    17.3532  -11.0163
            35  C1b C    17.3786   -8.5985
            36  C1a C    18.7600   -8.5989
BOND        39
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    5  18 1 #Up
            22   14  19 1 #Up
            23   12  20 1 #Up
            24   16  21 1 #Up
            25   17  22 1 #Up
            26   10  23 1 #Down
            27   17  24 1 #Down
            28    2  25 2
            29   22  26 2
            30   22  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   30  31 1
            35   29  32 2
            36   24  33 1
            37   33  34 2
            38   33  35 1
            39   35  36 1

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