KEGG   DRUG: Bepotastine besylate
Entry
D01654                      Drug                                   
Name
Bepotastine besylate (USAN);
Bepotastine besilate (JP18);
Bepreve (TN);
Talion (TN)
Product
BEPREVE (Bausch & Lomb Incorporated)
  Generic
BEPOTASTINE BESILATE (Apotex Corp.), BEPOTASTINE BESILATE (Bausch & Lomb Americas), BEPOTASTINE BESILATE (Bausch & Lomb Incorporated), BEPOTASTINE BESILATE (Mylan Pharmaceuticals), BEPOTASTINE BESILATE OPHTHALMIC SOLUTION 1.5% (Alembic Pharmaceuticals Limited), BEPOTASTINE BESILATE OPHTHALMIC SOLUTION 1.5% (Alembic Pharmaceuticals)
Formula
C21H25ClN2O3. C6H6O3S
Exact mass
546.1591
Mol weight
547.0628
Structure
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Dermatological agent
 DG03243  Atopic dermatitis agent
Remark
Therapeutic category: 4490
Chemical structure group: DG01327
Product (DG01327): D01654<JP/US>
Efficacy
Antiallergic, Antipruritic, H1 receptor antagonist
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Anti-allergy Agents
   Antihistamine and Mast Cell Stabilizer
    Bepotastine
     D01654  Bepotastine besylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D01654  Bepotastine besylate (USAN); Bepotastine besilate (JP18)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Bepotastine
    D01654  Bepotastine besylate (USAN)
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01327  Bepotastine
     D01654  Bepotastine besylate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01654  Bepotastine besylate
Drug classes [BR:br08332]
 Anti-allergic agent
  DG01482  Histamine receptor H1 antagonist
   D01654  Bepotastine besylate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01654  Bepotastine besylate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D01654  Bepotastine besylate (USAN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01654  Bepotastine besilate
  D01654  Bepotastine besylate tablets
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01654
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01654
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01654
Rx-to-OTC switch list in Japan [br08314.html]
 D01654
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01327  Bepotastine
Other DBs
CAS: 190786-44-8
PubChem: 7848717
ChEBI: 31281
LigandBox: D01654
NIKKAJI: J835.189I
KCF data

ATOM        37
            1   C8x C    30.3566  -24.1077
            2   C8x C    30.3566  -25.5052
            3   C8x C    31.5699  -26.2040
            4   C8x C    32.7759  -25.5052
            5   C8x C    32.7759  -24.1077
            6   C8y C    31.5699  -23.4089
            7   S4a S    31.5716  -22.0113
            8   O1d O    31.6335  -20.6138
            9   O1d O    32.9682  -22.0113
            10  O1d O    30.1730  -22.0113
            11  C1c C    19.5115  -23.1679
            12  C8y C    18.2900  -23.8520
            13  C8y C    20.7041  -23.8870
            14  O2a O    19.5290  -21.7650
            15  C8x C    18.2491  -25.2547
            16  C8x C    17.0857  -23.1270
            17  C1y C    20.8092  -21.0812
            18  C8x C    17.0448  -25.9387
            19  C8x C    15.8582  -23.8168
            20  C8y C    15.8813  -25.2256
            21  X   Cl   14.6073  -25.9096
            22  C1x C    21.9317  -21.7852
            23  C1x C    23.1417  -21.1013
            24  N1y N    23.1544  -19.7115
            25  C1x C    21.9571  -19.0056
            26  C1x C    20.7705  -19.7360
            27  C1b C    24.3620  -19.0070
            28  C1b C    25.5698  -19.6991
            29  C1b C    26.7776  -18.9998
            30  C6a C    27.9854  -19.6922
            31  O6a O    29.1932  -18.9929
            32  O6a O    27.9885  -21.0907
            33  C8x C    20.7475  -25.3060
            34  C8x C    21.8746  -26.0274
            35  C8x C    23.1679  -25.3514
            36  C8x C    23.1946  -23.9325
            37  N5x N    21.9274  -23.2110
BOND        39
            1     6   1 1
            2     6   7 1
            3     7   8 1
            4     1   2 2
            5     7   9 2
            6     2   3 1
            7     7  10 2
            8     3   4 2
            9     4   5 1
            10    5   6 2
            11   11  12 1
            12   11  13 1
            13   11  14 1 #Down
            14   12  15 2
            15   12  16 1
            16   14  17 1
            17   15  18 1
            18   16  19 2
            19   18  20 2
            20   20  21 1
            21   19  20 1
            22   17  22 1
            23   22  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   26  17 1
            28   24  27 1
            29   27  28 1
            30   28  29 1
            31   29  30 1
            32   30  31 1
            33   30  32 2
            34   13  33 2
            35   33  34 1
            36   34  35 2
            37   35  36 1
            38   36  37 2
            39   13  37 1

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