| Entry |
|
|---|
| Name |
Nipradilol (JAN/INN);
Hypadil (TN) |
|---|
| Formula |
C15H22N2O6
|
|---|
| Exact mass |
326.1478
|
|---|
| Mol weight |
326.345
|
|---|
| Structure |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
|
|---|
| Remark |
|
|---|
| Efficacy |
Antiglaucoma, Antihypertensive, Vasodilator, alpha1/beta-Adrenergic receptor antagonist |
|---|
| Comment |
Propranolol derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1319 Others
D01691 Nipradilol (JAN/INN)
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D01691 Nipradilol (JAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
D01691 Nipradilol
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
D01691 Nipradilol
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
D01691 Nipradilol
Drug classes [BR:br08332]
Cardiovascular agent
DG03231 Antihypertensive
D01691 Nipradilol
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
D01691 Nipradilol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D01691 Nipradilol (JAN/INN) <JP>
ADRB
D01691 Nipradilol (JAN/INN) <JP>
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 23
1 O2a O 19.3200 -20.7900
2 C1b C 20.5100 -20.0900
3 C1c C 21.7000 -20.7900
4 C1b C 22.9600 -20.0900
5 O1a O 21.7000 -22.1900
6 N1b N 24.1500 -20.7900
7 C1c C 25.3400 -20.0900
8 C1a C 26.5300 -20.7900
9 C1a C 25.3400 -18.6900
10 C8y C 19.3200 -22.1900
11 C8y C 18.1076 -22.8900
12 C8y C 18.1076 -24.2900
13 C8x C 19.3200 -24.9900
14 C8x C 20.5324 -24.2900
15 C8x C 20.5324 -22.8900
16 O2x O 16.8951 -22.1900
17 C1x C 15.6827 -22.8900
18 C1y C 15.6827 -24.2900
19 C1x C 16.8951 -24.9900
20 O2a O 14.4682 -24.9912
21 N2b N 13.2717 -24.3002 #+
22 O3a O 11.9449 -25.1254 #-
23 O3a O 13.2716 -22.8903
BOND 24
1 1 2 1
2 2 3 1
3 3 4 1
4 3 5 1
5 4 6 1
6 6 7 1
7 7 8 1
8 7 9 1
9 1 10 1
10 10 11 2
11 11 12 1
12 12 13 2
13 13 14 1
14 14 15 2
15 10 15 1
16 11 16 1
17 16 17 1
18 17 18 1
19 18 19 1
20 12 19 1
21 18 20 1
22 20 21 1
23 21 22 1
24 21 23 2
|
|---|
