KEGG   DRUG: Ciclesonide
Entry
D01703                      Drug                                   
Name
Ciclesonide (JAN/USAN/INN);
Alvesco (TN);
Omnaris (TN);
Zetonna (TN)
Product
ALVESCO (Covis Pharma US), ALVESCO (Sixarp), ALVESCO (Sixarp), OMNARIS (Covis Pharma US), ZETONNA (Covis Pharma US)
Formula
C32H44O7
Exact mass
540.3087
Mol weight
540.6876
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2290
ATC code: R01AD13 R03BA08
Product: D01703<JP/US>
Efficacy
Antiasthmatic, Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Allergic rhinitis [DS:H01360]
Asthma [DS:H00079]
Comment
Glucocorticoid, acetal derivative
Treatment of asthma as prophylactic therapy in adults and adolescents
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD13 Ciclesonide
      D01703  Ciclesonide (JAN/USAN/INN) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA08 Ciclesonide
      D01703  Ciclesonide (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Anti-inflammatories, Inhaled Corticosteroids
   Ciclesonide
    D01703  Ciclesonide (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   229  Miscellaneous
    2290  Miscellaneous
     D01703  Ciclesonide (JAN/USAN/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    D01703  Ciclesonide
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D01703  Ciclesonide
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D01703  Ciclesonide
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01703  Ciclesonide (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01703
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01703
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01703
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01703
Other DBs
CAS: 126544-47-6
PubChem: 7848766
ChEBI: 31397
LigandBox: D01703
NIKKAJI: J561.842H
KCF data

ATOM        39
            1   C2x C    14.0700  -23.5900
            2   C5x C    14.0700  -24.9900
            3   C2x C    15.2600  -25.6900
            4   C2y C    16.5200  -24.9900
            5   C1z C    16.5200  -23.5900
            6   C2x C    15.2600  -22.8900
            7   C1x C    17.7100  -25.6900
            8   C1x C    18.9000  -24.9900
            9   C1y C    18.9000  -23.5900
            10  C1y C    17.7100  -22.8900
            11  C1y C    20.1600  -22.8900
            12  C1z C    20.1600  -21.4900
            13  C1x C    18.9000  -20.7900
            14  C1y C    17.7100  -21.4900
            15  C1x C    22.5400  -22.8900
            16  C1y C    22.5400  -21.4900
            17  C1z C    21.3500  -20.7900
            18  O5x O    12.8800  -25.6900
            19  C1a C    16.5200  -22.1900
            20  C1a C    20.1600  -20.0900
            21  O1a O    16.5200  -20.7900
            22  C5a C    21.3500  -19.3900
            23  O5a O    22.5400  -18.6900
            24  C1b C    20.1600  -18.6900
            25  O7a O    20.1600  -17.2900
            26  C7a C    18.9700  -16.5900
            27  C1c C    17.7800  -17.2900
            28  O6a O    18.9700  -15.1900
            29  C1a C    16.5900  -16.5900
            30  C1a C    17.7800  -18.6900
            31  O2x O    22.5400  -20.0900
            32  O2x O    23.9400  -21.1400
            33  C1y C    23.9400  -20.0900
            34  C1x C    25.1300  -17.9900
            35  C1y C    25.1300  -19.3900
            36  C1x C    26.3200  -20.0900
            37  C1x C    27.5800  -19.3900
            38  C1x C    27.5800  -17.9900
            39  C1x C    26.3200  -17.2900
BOND        44
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   12  20 1 #Up
            24   14  21 1 #Up
            25   17  22 1 #Up
            26   22  23 2
            27   22  24 1
            28   24  25 1
            29   25  26 1
            30   26  27 1
            31   26  28 2
            32   27  29 1
            33   27  30 1
            34   17  31 1
            35   16  32 1
            36   31  33 1
            37   32  33 1
            38   34  35 1
            39   35  36 1
            40   36  37 1
            41   37  38 1
            42   38  39 1
            43   34  39 1
            44   33  35 1 #Down

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