KEGG   DRUG: Fluticasone propionate
Entry
D01708                      Drug                                   
Name
Fluticasone propionate (JAN/USP);
Cutivate (TN);
Flonase (TN);
Flovent (TN)
Product
  Generic
FLUTICASONE (Direct RX), FLUTICASONE (Lake Erie Medical DBA Quality Care Products LLC), FLUTICASONE (Preferred Pharmaceuticals), FLUTICASONE (Proficient Rx LP), FLUTICASONE (RPK Pharmaceuticals), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (A-S Medication Solutions), FLUTICASONE PROPIONATE (Advanced Rx Pharmacy of Tennessee), FLUTICASONE PROPIONATE (Apotex Corp.), FLUTICASONE PROPIONATE (Asclemed USA), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Bryant Ranch Prepack), FLUTICASONE PROPIONATE (Cosette Pharmaceuticals), FLUTICASONE PROPIONATE (Cosette Pharmaceuticals), FLUTICASONE PROPIONATE (Direct_RX), FLUTICASONE PROPIONATE (Doc Rx), FLUTICASONE PROPIONATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), FLUTICASONE PROPIONATE (Glenmark Pharmaceuticals), FLUTICASONE PROPIONATE (Golden State Medical Supply), FLUTICASONE PROPIONATE (Hikma Pharmaceuticals USA), FLUTICASONE PROPIONATE (NuCare Pharmaceuticals), FLUTICASONE PROPIONATE (NuCare Pharmaceuticals), FLUTICASONE PROPIONATE (Padagis Israel Pharmaceuticals), FLUTICASONE PROPIONATE (Padagis Israel Pharmaceuticals), FLUTICASONE PROPIONATE (Padagis Israel Pharmaceuticals), FLUTICASONE PROPIONATE (Prasco Laboratories), FLUTICASONE PROPIONATE (Prasco Laboratories), FLUTICASONE PROPIONATE (Preferred Pharmaceuticals), FLUTICASONE PROPIONATE (Preferred Pharmaceuticals), FLUTICASONE PROPIONATE (Proficient Rx LP), FLUTICASONE PROPIONATE (Proficient Rx LP), FLUTICASONE PROPIONATE (Proficient Rx LP), FLUTICASONE PROPIONATE (Proficient Rx LP), FLUTICASONE PROPIONATE (Quality Care Products), FLUTICASONE PROPIONATE (REMEDYREPACK), FLUTICASONE PROPIONATE (RPK Pharmaceuticals), FLUTICASONE PROPIONATE (RPK Pharmaceuticals), FLUTICASONE PROPIONATE (RPK Pharmaceuticals), FLUTICASONE PROPIONATE (RPK Pharmaceuticals), FLUTICASONE PROPIONATE (Taro Pharmaceuticals U.S.A.), FLUTICASONE PROPIONATE SPRAY, METERED (Chartwell RX)
Formula
C25H31F3O5S
Exact mass
500.1844
Mol weight
500.5709
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1329 2290
ATC code: D07AC17 R01AD08 R03BA05
Chemical structure group: DG00420
Product (DG00420): D01708<JP/US> D06315<JP/US>
Product (mixture): D08699<JP/US> D10506<JP> D11656<US>
Efficacy
Antiasthmatic, Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Asthma [DS:H00079]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC17 Fluticasone
      D01708  Fluticasone propionate (JAN/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD08 Fluticasone
      D01708  Fluticasone propionate (JAN/USP) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA05 Fluticasone
      D01708  Fluticasone propionate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Fluticasone
     D01708  Fluticasone propionate (JAN/USP)
 Respiratory Tract/Pulmonary Agents
  Anti-inflammatories, Inhaled Corticosteroids
   Fluticasone
    D01708  Fluticasone propionate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   132  Otic and nasal agents
    1329  Others
     D01708  Fluticasone propionate (JAN/USP)
 2  Agents affecting individual organs
  22  Respiratory organ agents
   229  Miscellaneous
    2290  Miscellaneous
     D01708  Fluticasone propionate (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Fluticasone propionate
    D01708  Fluticasone propionate (JAN/USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00420  Fluticasone
     D01708  Fluticasone propionate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00420  Fluticasone
     D01708  Fluticasone propionate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D01708  Fluticasone propionate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01708  Fluticasone propionate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01708
Topical steroids potency [br08317.html]
 Classification in the USA
  D01708
Rx-to-OTC switch list in the USA [br08315.html]
 D01708
Rx-to-OTC switch list in Japan [br08314.html]
 D01708
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00420  Fluticasone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00420  Fluticasone
Other DBs
CAS: 80474-14-2
PubChem: 7848771
ChEBI: 31441
LigandBox: D01708
NIKKAJI: J457.058H
KCF data

ATOM        34
            1   C2x C    19.6000  -28.4200
            2   C5x C    19.6000  -29.7500
            3   C2x C    20.7900  -30.4500
            4   C2y C    21.9100  -29.7500
            5   C1z C    21.9100  -28.4200
            6   C2x C    20.7900  -27.7200
            7   C1y C    23.1000  -30.4500
            8   C1x C    24.3600  -29.7500
            9   C1y C    24.3600  -28.4200
            10  C1z C    23.1000  -27.7200
            11  C1y C    25.4100  -27.7200
            12  C1z C    25.4100  -26.3900
            13  C1x C    24.3600  -25.6900
            14  C1y C    23.1000  -26.3900
            15  C1x C    27.7200  -27.7200
            16  C1y C    27.7200  -26.3900
            17  C1z C    26.5300  -25.6900
            18  O5x O    18.4100  -30.4500
            19  C1a C    21.9100  -27.0200
            20  X   F    23.1000  -29.0500
            21  O1a O    21.9100  -25.6900
            22  C1a C    25.4100  -24.9900
            23  O7a O    27.9300  -24.7800
            24  C1a C    29.1200  -26.3900
            25  X   F    23.1000  -31.8500
            26  C5a C    26.5300  -24.2900
            27  O5a O    27.7900  -23.5900
            28  S2a S    25.2700  -23.5900
            29  C1b C    24.0800  -24.2900
            30  X   F    22.8900  -23.5900
            31  C7a C    29.1200  -24.0800
            32  C1b C    30.3100  -24.7800
            33  C1a C    31.5000  -24.0800
            34  O6a O    29.1200  -22.6800
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   10  20 1 #Down
            24   14  21 1 #Up
            25   12  22 1 #Up
            26   17  23 1 #Down
            27   16  24 1 #Down
            28    7  25 1 #Down
            29   17  26 1 #Up
            30   26  27 2
            31   26  28 1
            32   28  29 1
            33   29  30 1
            34   31  32 1
            35   31  23 1
            36   32  33 1
            37   31  34 2

» Japanese version   » Back

DBGET integrated database retrieval system