| Entry |
|
|---|
| Name |
Amorolfine hydrochloride (JAN);
Pekiron (TN) |
|---|
| Formula |
C21H35NO. HCl
|
|---|
| Exact mass |
353.2485
|
|---|
| Mol weight |
353.9696
|
|---|
| Structure |
|
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| Simcomp |
|
|---|
| Remark |
| Therapeutic category: | 2659 |
| Product (DG00376): | D01720<JP> |
|
|---|
| Efficacy |
Antifungal, Ergosterol biosynthesis inhibitor |
|---|
| Comment |
Morpholine derivative
|
|---|
| Target |
squalene epoxidase [KO: K00511] |
|---|
| Pathway |
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
D01A ANTIFUNGALS FOR TOPICAL USE
D01AE Other antifungals for topical use
D01AE16 Amorolfine
D01720 Amorolfine hydrochloride (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
26 Epidermides
265 Antiparasitic dermatosis agents
2659 Others
D01720 Amorolfine hydrochloride (JAN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
58 Ringworm drugs
D01720 Amorolfine hydrochloride (JAN)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Amorolfine
D01720 Amorolfine hydrochloride (JAN)
Second-class OTC drugs
Inorganic and organic chemicals
Amorolfine
D01720 Amorolfine hydrochloride (JAN)
Antimicrobials [BR:br08307]
Antifungals
Ergosterol biosynthesis inhibitor
Other ergosterol biosynthesis inhibitor
D01720 Amorolfine hydrochloride (JAN) <JP>
Rx-to-OTC switch list in Japan [br08314.html]
D01720
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| Other DBs |
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| KCF data |
ATOM 24
1 C8y C 17.0998 -17.3199
2 C8x C 17.0998 -18.7218
3 C8x C 18.3179 -19.4261
4 C8y C 19.5288 -18.7218
5 C8x C 19.5288 -17.3199
6 C8x C 18.3179 -16.6224
7 C1b C 20.7349 -19.4192
8 C1c C 21.9395 -18.7147
9 C1b C 23.1512 -19.4121
10 N1y N 24.3630 -18.7076
11 C1x C 25.5745 -19.4050
12 C1y C 26.7863 -18.7006
13 C1a C 21.9365 -17.3127
14 C1x C 24.3599 -17.3057
15 C1y C 25.5733 -16.6057
16 O2x O 26.7899 -17.3003
17 C1d C 15.8812 -16.6224
18 C1b C 15.8793 -15.2204
19 C1a C 14.6670 -17.3214
20 C1a C 16.8733 -15.6277
21 C1a C 14.6633 -14.5176
22 C1a C 25.5702 -15.2033
23 C1a C 27.9767 -19.3880
24 X Cl 29.9321 -17.1918
BOND 24
1 4 5 1
2 11 12 1
3 5 6 2
4 6 1 1
5 8 13 1
6 10 14 1
7 4 7 1
8 14 15 1
9 12 16 1
10 7 8 1
11 15 16 1
12 1 2 2
13 1 17 1
14 8 9 1
15 17 18 1
16 2 3 1
17 17 19 1
18 9 10 1
19 17 20 1
20 3 4 2
21 18 21 1
22 10 11 1
23 15 22 1 #Down
24 12 23 1 #Down
|
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