| Entry |
|
|---|
| Name |
Domperidone (JP18/USAN/INN);
Motilium (TN) |
|---|
| Formula |
C22H24ClN5O2
|
|---|
| Exact mass |
425.1619
|
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| Mol weight |
425.9113
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
Gastrointestinal agent
DG01763 Propulsive
DG01762 Antiemetic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 2399 |
| Product (DG00057): | D01745<JP> |
|
|---|
| Efficacy |
Anti-emetic, Prokinetic, Dopamine D2 receptor antagonist |
|---|
| Comment |
Benzamide derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07213 | Dopamine receptor agonists/antagonists |
|
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| Other map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
A03F PROPULSIVES
A03FA Propulsives
A03FA03 Domperidone
D01745 Domperidone (JP18/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
239 Miscellaneous
2399 Others
D01745 Domperidone (JP18/USAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00057 Domperidone
D01745 Domperidone
Gastrointestinal agent
DG01763 Propulsive
DG00057 Domperidone
D01745 Domperidone
DG01762 Antiemetic
DG00057 Domperidone
D01745 Domperidone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00057 Domperidone
D01745 Domperidone
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D01745 Domperidone (JP18/USAN/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01745 Domperidone
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01745
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00057 Domperidone
Gastrointestinal agent
DG01763 Propulsive
DG00057 Domperidone
DG01762 Antiemetic
DG00057 Domperidone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00057 Domperidone
|
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| Other DBs |
|
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| KCF data |
ATOM 30
1 C1x C 33.2500 -28.4200
2 C1y C 33.2500 -29.8200
3 C1x C 34.4624 -30.5200
4 C1x C 35.6749 -29.8200
5 N1y N 35.6749 -28.4200
6 C1x C 34.4624 -27.7200
7 N4y N 32.0376 -30.5200
8 C1b C 36.9060 -27.7090
9 C1b C 38.1112 -28.4047
10 C1b C 39.2935 -27.7219
11 N4y N 40.4875 -28.4112
12 C8y C 30.9024 -29.7327
13 N4x N 29.8066 -30.5707
14 C8y C 30.2649 -31.8718
15 C8y C 31.6440 -31.8379
16 C8x C 29.5949 -33.1010
17 C8y C 30.3244 -34.2259
18 C8x C 31.7035 -34.2621
19 C8x C 32.3735 -33.0328
20 X Cl 29.6349 -35.4565
21 O5x O 30.8698 -28.3500
22 C8y C 40.8974 -29.7499
23 N4x N 42.3028 -29.7732
24 C8y C 42.7593 -28.4437
25 C8y C 41.6359 -27.5989
26 O5x O 40.0495 -30.8770
27 C8x C 44.1489 -27.7737
28 C8x C 44.1446 -26.3737
29 C8x C 42.9251 -25.6747
30 C8x C 41.6449 -26.3785
BOND 34
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 2 7 1
8 5 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 7 12 1
13 12 13 1
14 13 14 1
15 14 15 1
16 7 15 1
17 14 16 2
18 16 17 1
19 17 18 2
20 18 19 1
21 15 19 2
22 17 20 1
23 12 21 2
24 11 22 1
25 22 23 1
26 23 24 1
27 24 25 1
28 11 25 1
29 22 26 2
30 24 27 2
31 27 28 1
32 28 29 2
33 29 30 1
34 25 30 2
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