| Entry |
|
|---|
| Name |
Pirmenol hydrochloride hydrate (JAN);
Pimenol (TN) |
|---|
| Formula |
C22H30N2O. HCl. H2O
|
|---|
| Exact mass |
392.2231
|
|---|
| Mol weight |
392.9626
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
|
|---|
| Remark |
| Therapeutic category: | 2129 |
| Product (DG01381): | D01785<JP> |
|
|---|
| Efficacy |
Antiarrhythmic, Sodium channel blocker |
|---|
| Comment |
Class I antiarrhythmic agent (Ia)
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2129 Others
D01785 Pirmenol hydrochloride hydrate (JAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG01381 Pirmenol
D01785 Pirmenol hydrochloride hydrate
Drug classes [BR:br08332]
Cardiovascular agent
DG01653 Antiarrhythmics
D01785 Pirmenol hydrochloride hydrate
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D01785 Pirmenol hydrochloride hydrate (JAN) <JP>
SCN2A
D01785 Pirmenol hydrochloride hydrate (JAN) <JP>
SCN3A
D01785 Pirmenol hydrochloride hydrate (JAN) <JP>
SCN4A
D01785 Pirmenol hydrochloride hydrate (JAN) <JP>
SCN5A
D01785 Pirmenol hydrochloride hydrate (JAN) <JP>
SCN8A
D01785 Pirmenol hydrochloride hydrate (JAN) <JP>
SCN9A
D01785 Pirmenol hydrochloride hydrate (JAN) <JP>
SCN10A
D01785 Pirmenol hydrochloride hydrate (JAN) <JP>
SCN11A
D01785 Pirmenol hydrochloride hydrate (JAN) <JP>
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG01381 Pirmenol
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 27
1 C8x C 26.8670 -19.6231
2 C8x C 26.8670 -21.0248
3 C8x C 28.0838 -21.7256
4 C8x C 29.2935 -21.0248
5 C8y C 29.2935 -19.6231
6 C8x C 28.0838 -18.9223
7 C1d C 30.5080 -18.9233
8 C8y C 31.7214 -19.6250
9 C8x C 31.7148 -21.0246
10 C8x C 32.9282 -21.7265
11 C8x C 34.1425 -21.0265
12 C8x C 34.1435 -19.6248
13 N5x N 32.9303 -18.9231
14 C1b C 30.5058 -17.5277
15 C1b C 31.7163 -16.8269
16 C1b C 31.7163 -15.4323
17 N1y N 32.9269 -14.7315
18 C1y C 34.1391 -15.4294
19 C1x C 35.3498 -14.7286
20 C1x C 35.3481 -13.3297
21 C1x C 34.1357 -12.6318
22 C1y C 32.9252 -13.3326
23 C1a C 31.7104 -12.6331
24 C1a C 34.1408 -16.8311
25 O1a O 29.2955 -18.2233
26 X Cl 38.3976 -18.6187
27 O0 O 38.7100 -16.8700
BOND 27
1 11 12 1
2 12 13 2
3 13 8 1
4 6 1 1
5 7 14 1
6 14 15 1
7 5 7 1
8 15 16 1
9 16 17 1
10 7 8 1
11 1 2 2
12 2 3 1
13 3 4 2
14 4 5 1
15 5 6 2
16 17 18 1
17 18 19 1
18 19 20 1
19 20 21 1
20 21 22 1
21 22 17 1
22 8 9 2
23 22 23 1 #Down
24 9 10 1
25 18 24 1 #Down
26 10 11 2
27 7 25 1
|
|---|
