KEGG   DRUG: Sapropterin dihydrochloride
Entry
D01798                      Drug                                   
Name
Sapropterin dihydrochloride (USAN);
Sapropterin hydrochloride (JAN);
Biopten (TN);
Kuvan (TN)
Product
KUVAN (BioMarin Pharmaceutical), SAPROPTERIN DIHYDROCHLORIDE (Dr. Reddys Laboratories)
  Generic
JAVYGTOR (Dr. Reddys Laboratories), JAVYGTOR (Dr. Reddys Laboratories), JAVYGTOR (Dr. Reddys Laboratories), SAPROPTERIN DIHYDROCHLORIDE (Camber Pharmaceuticals), SAPROPTERIN DIHYDROCHLORIDE (Camber Pharmaceuticals), SAPROPTERIN DIHYDROCHLORIDE (Dr. Reddys Laboratories), SAPROPTERIN DIHYDROCHLORIDE (NorthStar RxLLC), SAPROPTERIN DIHYDROCHLORIDE (NorthStar RxLLC), SAPROPTERIN DIHYDROCHLORIDE (Par Pharmaceutical), SAPROPTERIN DIHYDROCHLORIDE (Par Pharmaceutical), SAPROPTERIN DIHYDROCHLORIDE (Par Pharmaceutical)
Formula
C9H15N5O3. 2HCl
Exact mass
313.0708
Mol weight
314.169
Structure
Simcomp
Remark
Therapeutic category: 3999
ATC code: A16AX07
Chemical structure group: DG00147
Product (DG00147): D01798<JP/US>
Efficacy
Antihyperphenylalaninemia, Cofactor replacement (tetrahydrobiopterin)
  Disease
Phenylketonuria, BH4-responsive [DS:H00167]
Comment
Cofactor replacement
Treatment of mild-to-moderate phenylketonuria (PKU)
Target
Tetrahydrobiopterin [CPD:C00272]
  Network
nt06016  Phenylalanine and tyrosine metabolism
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AX Various alimentary tract and metabolism products
     A16AX07 Sapropterin
      D01798  Sapropterin dihydrochloride (USAN) <JP/US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Sapropterin
   D01798  Sapropterin dihydrochloride (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D01798  Sapropterin dihydrochloride (USAN); Sapropterin hydrochloride (JAN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01798
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01798
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01798
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D01798
Other DBs
CAS: 69056-38-8
PubChem: 7848860
ChEBI: 32120
LigandBox: D01798
NIKKAJI: J1.219.960K
KCF data

ATOM        19
            1   N4x N    12.4915  -16.1444
            2   C8y C    12.4915  -17.5456
            3   N5x N    13.7079  -18.2462
            4   C8y C    13.7079  -15.4438
            5   C8y C    14.9172  -16.1444
            6   C8y C    14.9111  -17.5456
            7   N1x N    16.1215  -18.2514
            8   C1x C    17.3381  -17.5559
            9   C1y C    17.3441  -16.1547
            10  N1x N    16.1336  -15.4490
            11  C1c C    18.5491  -15.4580
            12  C1c C    19.7592  -16.1586
            13  C1a C    20.9693  -15.4650
            14  O1a O    19.7561  -17.5598
            15  O1a O    18.5496  -14.0569
            16  N1a N    11.2784  -18.2468
            17  O5x O    13.7096  -14.0426
            18  X   Cl   24.7359  -16.7106
            19  X   Cl   24.7359  -16.7106
BOND        18
            1     8   9 1
            2     9  10 1
            3    10   5 1
            4     4   1 1
            5     9  11 1
            6    11  12 1
            7    12  13 1
            8     1   2 1
            9    12  14 1 #Down
            10    2   3 2
            11   11  15 1 #Up
            12    3   6 1
            13    2  16 1
            14    5   4 1
            15    4  17 2
            16    5   6 2
            17    6   7 1
            18    7   8 1
BRACKET     1    23.6600  -17.6400   23.6600  -15.8200
            1    25.2700  -15.8200   25.2700  -17.6400
            1  2
 ORIGINAL  1   19
 REPEAT    1   20

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Ontology (7)   
   KEGG BRITE (7)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
All databases (14)   

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