| Entry |
|
|---|
| Name |
Nicorandil (JP18/USAN/INN);
Sigmart (TN) |
|---|
| Formula |
C8H9N3O4
|
|---|
| Exact mass |
211.0593
|
|---|
| Mol weight |
211.1748
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01583 ATP-sensitive potassium channel opener
DG01657 Nitrovasodilator
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
|
|---|
| Remark |
| Therapeutic category: | 2171 |
|
|---|
| Efficacy |
Vasodilator (coronary) |
|---|
| Comment |
Nicothinic acid derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07232 | Potassium channel blocking and opening drugs |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01D VASODILATORS USED IN CARDIAC DISEASES
C01DX Other vasodilators used in cardiac diseases
C01DX16 Nicorandil
D01810 Nicorandil (JP18/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
217 Vasodilators
2171 Coronary dilators
D01810 Nicorandil (JP18/USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01583 ATP-sensitive potassium channel opener
D01810 Nicorandil
DG01657 Nitrovasodilator
D01810 Nicorandil
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
D01810 Nicorandil
Target-based classification of drugs [BR:br08310]
Transporters
ABC transporters
ABCC subfamily
ABCC8(SUR1)/KCNJ11(KIR6.2)
D01810 Nicorandil (JP18/USAN/INN) <JP>
ABCC9(SUR2)/KCNJ11(KIR6.2)
D01810 Nicorandil (JP18/USAN/INN) <JP>
Enzymes
Lyases (EC4)
Phosphorus-oxygen lyases
GUCY1A
D01810 Nicorandil (JP18/USAN/INN) <JP>
GUCY1B
D01810 Nicorandil (JP18/USAN/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01810 Nicorandil
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| Other DBs |
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| KCF data |
ATOM 15
1 C8x C 19.6303 -15.6381
2 C8x C 19.6303 -17.0409
3 C8x C 20.8481 -17.7423
4 C8y C 22.0587 -17.0409
5 C8x C 22.0587 -15.6381
6 N5x N 20.8481 -14.9368
7 C5a C 23.2647 -17.7351
8 N1b N 24.4762 -17.0338
9 C1b C 25.6877 -17.7282
10 C1b C 26.8992 -17.0268
11 O2a O 28.1106 -17.7210
12 N2b N 29.3221 -17.0196 #+
13 O3a O 30.5336 -17.7139 #-
14 O5a O 23.2664 -19.1379
15 O3a O 29.3190 -15.6169
BOND 15
1 1 2 2
2 7 8 1
3 2 3 1
4 8 9 1
5 3 4 2
6 9 10 1
7 4 5 1
8 10 11 1
9 5 6 2
10 11 12 1
11 6 1 1
12 12 13 1
13 7 14 2
14 4 7 1
15 12 15 2
|
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