| Entry |
|
|---|
| Name |
Alclometasone dipropionate (JAN/USP);
Aclovate (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C28H37ClO7
|
|---|
| Exact mass |
520.2228
|
|---|
| Mol weight |
521.0422
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Dermatological agent
DG03243 Atopic dermatitis agent
|
|---|
| Remark |
| Therapeutic category: | 2646 |
| Product (DG00415): | D01820<JP/US> |
|
|---|
| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB10 Alclometasone
D01820 Alclometasone dipropionate (JAN/USP) <JP/US>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA10 Alclometasone
D01820 Alclometasone dipropionate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
Dermatitis and Pruitus Agents
Glucocorticoids, Low Potency
Alclometasone
D01820 Alclometasone dipropionate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2646 Adrenocorticotropic hormones
D01820 Alclometasone dipropionate (JAN/USP)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00415 Alclometasone
D01820 Alclometasone dipropionate
Dermatological agent
DG03243 Atopic dermatitis agent
D01820 Alclometasone dipropionate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D01820 Alclometasone dipropionate
Dermatological agent
DG03243 Atopic dermatitis agent
D01820 Alclometasone dipropionate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D01820 Alclometasone dipropionate (JAN/USP) <JP/US>
Topical steroids potency [br08317.html]
Classification in the USA
D01820
Classification in Japan
D01820
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00415 Alclometasone
|
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| Other DBs |
|
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| KCF data |
ATOM 36
1 C2x C 19.1662 -17.6173
2 C5x C 19.1662 -18.9788
3 C2x C 20.3484 -19.6596
4 C2x C 20.3484 -16.9363
5 C1z C 21.5234 -17.6173
6 C2y C 21.5174 -18.9788
7 C1x C 22.6938 -19.6648
8 C1y C 23.8760 -18.9889
9 C1y C 22.7055 -16.9416
10 C1y C 23.8760 -17.6302
11 C1x C 23.8982 -14.9141
12 C1y C 22.6466 -15.5835
13 C1z C 25.0689 -15.6027
14 C1y C 25.0525 -16.9568
15 C1x C 27.4434 -16.9390
16 C1y C 27.4139 -15.6313
17 C1z C 26.2495 -14.9400
18 O5x O 17.9874 -19.6603
19 C1a C 21.5112 -16.2556
20 X Cl 25.0537 -19.6724
21 C1a C 25.0598 -14.2869
22 O1a O 21.5430 -14.8930
23 C5a C 26.2425 -13.2278
24 C1b C 25.0599 -12.5530
25 O7a O 27.4252 -14.2477
26 O5a O 27.4136 -12.5401
27 C7a C 29.1328 -14.2477
28 C1a C 28.7732 -15.6300
29 O7a O 23.8841 -13.2399
30 C7a C 22.7016 -12.5652
31 C1b C 21.5257 -13.2520
32 O6a O 22.6705 -11.1576
33 C1a C 20.3430 -12.5773
34 O6a O 29.8136 -15.4267
35 C1b C 29.8136 -13.0685
36 C1a C 31.1753 -13.0685
BOND 39
1 2 18 2
2 9 5 1
3 5 19 1 #Up
4 5 4 1
5 4 1 2
6 8 20 1 #Down
7 1 2 1
8 9 10 1
9 13 21 1 #Up
10 10 14 1
11 12 22 1 #Up
12 13 11 1
13 17 23 1 #Up
14 23 26 2
15 11 12 1
16 23 24 1
17 12 9 1
18 17 25 1 #Down
19 2 3 1
20 3 6 2
21 25 27 1
22 5 6 1
23 16 28 1 #Down
24 6 7 1
25 24 29 1
26 7 8 1
27 29 30 1
28 13 14 1
29 30 31 1
30 15 16 1
31 30 32 2
32 16 17 1
33 31 33 1
34 17 13 1
35 27 34 2
36 14 15 1
37 27 35 1
38 8 10 1
39 35 36 1
|
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