| Entry |
|
|---|
| Name |
Arotinolol hydrochloride (JP18);
Almarl (TN) |
|---|
| Formula |
C15H21N3O2S3. HCl
|
|---|
| Exact mass |
407.0563
|
|---|
| Mol weight |
408.0021
|
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| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
|
|---|
| Remark |
| Therapeutic category: | 2123 |
| Product (DG01303): | D01830<JP> |
|
|---|
| Efficacy |
Antiarrhythmic, Antihypertensive, Vasodilator, Adrenergic receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07214 | beta-Adrenergic receptor agonists/antagonists |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2123 Beta blockers
D01830 Arotinolol hydrochloride (JP18)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG01303 Arotinolol
D01830 Arotinolol hydrochloride
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG01303 Arotinolol
D01830 Arotinolol hydrochloride
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG01303 Arotinolol
D01830 Arotinolol hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG03231 Antihypertensive
D01830 Arotinolol hydrochloride
DG01653 Antiarrhythmics
D01830 Arotinolol hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D01830 Arotinolol hydrochloride (JP18) <JP>
ADRB1
D01830 Arotinolol hydrochloride (JP18) <JP>
ADRB2
D01830 Arotinolol hydrochloride (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01830 Arotinolol hydrochloride
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG01303 Arotinolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG01303 Arotinolol
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG01303 Arotinolol
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 24
1 X Cl 25.4183 -19.9577
2 C1d C 26.1100 -13.5100
3 C1a C 27.3000 -14.2100
4 N1b N 24.9200 -14.2100
5 C1a C 26.1100 -12.1100
6 C1a C 27.3000 -12.8100
7 C1b C 23.7300 -13.5100
8 C1c C 22.5400 -14.2100
9 C1b C 21.3500 -13.5100
10 S2a S 20.1600 -14.2100
11 O1a O 22.5400 -15.6100
12 C8y C 20.1600 -15.6100
13 N5x N 19.0400 -16.4500
14 C8y C 19.4600 -17.7100
15 C8x C 20.8600 -17.7100
16 S2x S 21.2800 -16.4500
17 C8y C 18.6200 -18.8300
18 S2x S 17.2200 -18.8300
19 C8y C 16.8000 -20.1600
20 C8x C 17.9200 -21.0000
21 C8x C 19.0400 -20.1600
22 C5a C 15.4000 -20.1600
23 O5a O 14.7000 -18.9700
24 N1a N 14.7000 -21.3500
BOND 24
1 2 3 1
2 2 4 1
3 2 5 1
4 2 6 1
5 4 7 1
6 7 8 1
7 8 9 1
8 9 10 1
9 8 11 1
10 10 12 1
11 12 13 2
12 13 14 1
13 14 15 2
14 15 16 1
15 12 16 1
16 14 17 1
17 17 18 1
18 18 19 1
19 19 20 2
20 20 21 1
21 17 21 2
22 19 22 1
23 22 23 2
24 22 24 1
|
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