KEGG   DRUG: Pitavastatin calcium
Entry
D01862                      Drug                                   
Name
Pitavastatin calcium (JAN);
NK 104;
Livalo (TN)
Product
LIVALO (Kowa Pharmaceuticals America)
  Generic
PITAVASTATIN (Aurobindo Pharma Limited), PITAVASTATIN (AvKARE), PITAVASTATIN (Teva Pharmaceuticals), PITAVASTATIN (Upsher-Smith Laboratories), PITAVASTATIN CALCIUM (Mylan Pharmaceuticals), PITAVASTATIN CALCIUM (Zydus Lifesciences Limited), PITAVASTATIN CALCIUM (Zydus Pharmaceuticals USA)
Formula
(C25H23FNO4)2. Ca
Exact mass
880.2848
Mol weight
880.9836
Structure
Simcomp
Class
Hypolipidemic agent
 DG01946  Hypolipidemic agent
  DG01660  HMG-CoA reductase inhibitor
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
Therapeutic category: 2189
ATC code: C10AA08
Chemical structure group: DG01838
Product (DG01838): D01862<JP/US> D10568<JP> D11092<US>
Product (mixture): D12438<JP>
Efficacy
Antihyperlipidemic, HMG-CoA reductase inhibitor
  Disease
Primary hyperlipidemia [DS:H01635]
Mixed dyslipidemia [DS:H01635]
Target
HMGCR [HSA:3156] [KO:K00021]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Structure map
map07024  HMG-CoA reductase inhibitors
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA08 Pitavastatin
      D01862  Pitavastatin calcium (JAN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Pitavastatin
    D01862  Pitavastatin calcium (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2189  Others
     D01862  Pitavastatin calcium (JAN)
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG01660  HMG-CoA reductase inhibitor
    DG01838  Pitavastatin
     D01862  Pitavastatin calcium
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   DG01838  Pitavastatin
    D01862  Pitavastatin calcium
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01946  Hypolipidemic agent
   D01862  Pitavastatin calcium
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    HMGCR
     D01862  Pitavastatin calcium (JAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01862
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01862
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01862
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01862
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG01660  HMG-CoA reductase inhibitor
    DG01838  Pitavastatin
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   DG01838  Pitavastatin
Other DBs
CAS: 147526-32-7
PubChem: 7848924
ChEBI: 71258
LigandBox: D01862
NIKKAJI: J794.573F
KCF data

ATOM        63
            1   Z   Ca   38.8500  -13.7900 #2+
            2   C8x C    22.4000  -15.1200
            3   C8x C    22.4000  -16.5200
            4   C8x C    23.5900  -17.2200
            5   C8y C    24.8500  -16.5200
            6   C8y C    24.8500  -15.1200
            7   C8x C    23.5900  -14.4200
            8   N5x N    26.0400  -17.2200
            9   C8y C    27.2300  -16.5200
            10  C8y C    27.2300  -15.1200
            11  C8y C    26.0400  -14.4200
            12  C8y C    26.0400  -13.0200
            13  C8x C    27.2300  -12.3200
            14  C8x C    27.2300  -10.9200
            15  C8y C    26.0400  -10.2200
            16  C8x C    24.8500  -10.9200
            17  C8x C    24.8500  -12.3200
            18  C2b C    28.4200  -14.4200
            19  C2b C    29.6100  -15.1200
            20  X   F    26.0400   -8.8200
            21  C1y C    28.4200  -17.2200
            22  C1c C    30.8000  -14.4200
            23  C1b C    31.9900  -15.1200
            24  C1c C    33.1800  -14.4200
            25  C1b C    34.3700  -15.1200
            26  O1a O    30.8000  -13.0200
            27  O1a O    33.1800  -13.0200
            28  C6a C    35.5600  -14.4200
            29  O6a O    36.7500  -15.1200 #-
            30  O6a O    35.5600  -13.0200
            31  C1x C    29.8200  -17.2200
            32  C1x C    29.1200  -18.4100
            33  C8x C    22.4000  -15.1200
            34  C8x C    22.4000  -16.5200
            35  C8x C    23.5900  -17.2200
            36  C8y C    24.8500  -16.5200
            37  C8y C    24.8500  -15.1200
            38  C8x C    23.5900  -14.4200
            39  C8y C    26.0400  -14.4200
            40  C8y C    27.2300  -15.1200
            41  C8y C    27.2300  -16.5200
            42  N5x N    26.0400  -17.2200
            43  C1y C    28.4200  -17.2200
            44  C1x C    29.1200  -18.4100
            45  C1x C    29.8200  -17.2200
            46  C2b C    28.4200  -14.4200
            47  C2b C    29.6100  -15.1200
            48  C1c C    30.8000  -14.4200
            49  C1b C    31.9900  -15.1200
            50  C1c C    33.1800  -14.4200
            51  C1b C    34.3700  -15.1200
            52  C6a C    35.5600  -14.4200
            53  O6a O    36.7500  -15.1200 #-
            54  O6a O    35.5600  -13.0200
            55  O1a O    33.1800  -13.0200
            56  O1a O    30.8000  -13.0200
            57  C8y C    26.0400  -13.0200
            58  C8x C    27.2300  -12.3200
            59  C8x C    27.2300  -10.9200
            60  C8y C    26.0400  -10.2200
            61  C8x C    24.8500  -10.9200
            62  C8x C    24.8500  -12.3200
            63  X   F    26.0400   -8.8200
BOND        68
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     8   9 2
            9     9  10 1
            10   10  11 2
            11    6  11 1
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   12  17 1
            19   10  18 1
            20   18  19 2
            21   15  20 1
            22    9  21 1
            23   19  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   22  26 1 #Up
            28   24  27 1 #Up
            29   25  28 1
            30   28  29 1
            31   28  30 2
            32   32  31 1
            33   32  21 1
            34   21  31 1
            35   33  34 2
            36   34  35 1
            37   35  36 2
            38   36  37 1
            39   37  38 2
            40   33  38 1
            41   36  42 1
            42   42  41 2
            43   41  40 1
            44   40  39 2
            45   37  39 1
            46   39  57 1
            47   57  58 2
            48   58  59 1
            49   59  60 2
            50   60  61 1
            51   61  62 2
            52   57  62 1
            53   40  46 1
            54   46  47 2
            55   60  63 1
            56   41  43 1
            57   47  48 1
            58   48  49 1
            59   49  50 1
            60   50  51 1
            61   48  56 1 #Up
            62   50  55 1 #Up
            63   51  52 1
            64   52  53 1
            65   52  54 2
            66   44  45 1
            67   44  43 1
            68   43  45 1
BRACKET     1    22.0500  -18.8300   22.0500   -8.4000
            1    37.4500   -8.4000   37.4500  -18.8300
            1  2
 ORIGINAL  1    2   3   4   5   6   7  11  10   9   8  21  32  31  18  19  22
            1   23  24  25  28  29  30  27  26  12  13  14  15  16  17  20
 REPEAT    1   33  34  35  36  37  38  39  40  41  42  43  44  45  46  47  48
            1   49  50  51  52  53  54  55  56  57  58  59  60  61  62  63

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