KEGG   DRUG: Hydrocortisone probutate
Entry
D01886                      Drug                                   
Name
Hydrocortisone probutate (USAN);
Hydrocortisone butyrate propionate (JAN);
Hydrocortisone buteprate;
Pandel (TN)
Product
Formula
C28H40O7
Exact mass
488.2774
Mol weight
488.613
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Dermatological agent
 DG03243  Atopic dermatitis agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Same as: C13358
Therapeutic category: 2646
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07AB11 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
    D07AB Corticosteroids, moderately potent (group II)
     D07AB11 Hydrocortisone buteprate
      D01886  Hydrocortisone probutate (USAN) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Hydrocortisone
     D01886  Hydrocortisone probutate (USAN)
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D01886  Hydrocortisone probutate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01886  Hydrocortisone probutate (USAN); Hydrocortisone butyrate propionate (JAN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
     D01886  Hydrocortisone probutate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01886  Hydrocortisone probutate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
    D01886  Hydrocortisone probutate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D01886  Hydrocortisone probutate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01886  Hydrocortisone probutate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01886  Hydrocortisone probutate (USAN) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01886
Topical steroids potency [br08317.html]
 Classification in Japan
  D01886
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
Other DBs
CAS: 72590-77-3
PubChem: 7848948
ChEBI: 31675
LigandBox: D01886
NIKKAJI: J68.592E
KCF data

ATOM        35
            1   C1y C    13.5800  -11.5500
            2   C1y C    12.3900  -12.2500
            3   C1z C    13.5800  -10.2200
            4   C1x C    15.8900  -11.5500
            5   C1y C    11.2000  -11.5500
            6   C1x C    12.3900  -13.5800
            7   C1z C    14.7700   -9.5200
            8   C1x C    12.3900   -9.5200
            9   C1a C    13.5800   -8.8200
            10  C1x C    15.8900  -10.2200
            11  C1z C    10.0100  -12.2500
            12  C1y C    11.2000  -10.2200
            13  C1x C    11.2000  -14.2800
            14  C5a C    14.7700   -8.1200
            15  C2y C    10.0100  -13.5800
            16  C1x C     8.8200  -11.5500
            17  C1a C    10.0100  -10.8500
            18  O1a O    10.0100   -9.5200
            19  O5a O    13.5800   -7.4200
            20  C2x C     8.8200  -14.2800
            21  C1x C     7.6300  -12.2500
            22  C5x C     7.6300  -13.5800
            23  O5x O     6.4400  -14.2800
            24  C1b C    15.9600   -7.4200
            25  O7a O    17.1500   -8.1200
            26  C7a C    18.3400   -7.4200
            27  C1b C    19.5300   -8.1200
            28  C1a C    20.7200   -7.4200
            29  O6a O    18.3400   -6.0200
            30  O7a O    15.9600   -8.8200
            31  C7a C    17.1500   -9.5200
            32  C1b C    18.4100   -8.8900
            33  C1b C    19.6000   -9.5900
            34  C1a C    20.8600   -8.9600
            35  O6a O    17.1500  -10.9200
BOND        38
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1 #Up
            14   11  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   12  18 1 #Up
            18   14  19 2
            19   15  20 2
            20   16  21 1
            21   20  22 1
            22   22  23 2
            23    7  10 1
            24    8  12 1
            25   13  15 1
            26   21  22 1
            27   14  24 1
            28   24  25 1
            29   25  26 1
            30   26  27 1
            31   27  28 1
            32   26  29 2
            33    7  30 1 #Down
            34   30  31 1
            35   31  32 1
            36   32  33 1
            37   33  34 1
            38   31  35 2

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