KEGG   DRUG: Sivelestat sodium
Entry
D01918                      Drug                                   
Name
Sivelestat sodium (USAN);
Sivelestat sodium hydrate (JP18);
Sivelestat sodium for injection (JP18);
Elaspol (TN)
Formula
C20H21N2O7S. 4H2O. Na
Exact mass
528.139
Mol weight
528.5058
Structure
Simcomp
Remark
Therapeutic category: 3999
Chemical structure group: DG01401
Product (DG01401): D01918<JP>
Efficacy
Anti-inflammatory disease, Elastase inhibitor
Comment
Treatment of acute lung injury, Acute respiratory distress syndrome
Target
ELANE [HSA:1991] [KO:K01327]
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D01918  Sivelestat sodium (USAN); Sivelestat sodium hydrate (JP18); Sivelestat sodium for injection (JP18)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Serine peptidases
    ELANE
     D01918  Sivelestat sodium (USAN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01918  Sivelestat sodium hydrate
  D01918  Sivelestat sodium for injection
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01918
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01918
Other DBs
CAS: 201677-61-4
PubChem: 7848980
ChEBI: 32133
LigandBox: D01918
NIKKAJI: J1.606.661C
KCF data

ATOM        35
            1   Z   Na   33.1053  -16.5396 #+
            2   C8y C    23.9651  -17.7179
            3   S4a S    25.1386  -17.0284
            4   C8x C    23.9651  -19.0788
            5   C8x C    22.7856  -17.0284
            6   N1b N    26.3242  -17.7179
            7   C8x C    22.7856  -19.7562
            8   C8x C    21.6123  -17.7179
            9   C8y C    27.5036  -17.0284
            10  C8y C    21.6123  -19.0788
            11  C8x C    27.4915  -15.6673
            12  C8y C    28.6831  -17.7058
            13  O7a O    20.4267  -19.7562
            14  C8x C    28.6710  -14.9838
            15  C8x C    29.8626  -17.0222
            16  C7a C    19.0597  -19.0365
            17  C8x C    29.8567  -15.6614
            18  C1d C    17.7230  -19.8108
            19  C1a C    17.7230  -21.3591
            20  C1a C    16.3863  -19.0365
            21  C5a C    28.6858  -19.0660
            22  O5a O    27.5092  -19.7483
            23  N1b N    29.8651  -19.7438
            24  C1b C    31.0418  -19.0614
            25  C6a C    32.2210  -19.7392
            26  O6a O    33.3977  -19.0567 #-
            27  O6a O    32.1769  -21.0993
            28  O6a O    19.0287  -17.4918
            29  C1a C    16.3777  -20.5762
            30  O3c O    25.1527  -15.6329
            31  O3c O    25.1527  -18.4329
            32  O0  O    37.6599  -19.1799
            33  O0  O    37.6599  -19.1799
            34  O0  O    37.6599  -19.1799
            35  O0  O    37.6599  -19.1799
BOND        31
            1     3   6 1
            2     4   7 2
            3     5   8 1
            4     6   9 1
            5     7  10 1
            6     9  11 1
            7     9  12 2
            8    10  13 1
            9    11  14 2
            10   12  15 1
            11   13  16 1
            12   14  17 1
            13   16  18 1
            14   18  19 1
            15   18  20 1
            16    8  10 2
            17   15  17 2
            18   12  21 1
            19   21  22 2
            20   21  23 1
            21   23  24 1
            22   24  25 1
            23   25  26 1
            24    2   3 1
            25   25  27 2
            26    2   4 1
            27   16  28 2
            28    2   5 2
            29   18  29 1
            30    3  30 2
            31    3  31 2
BRACKET     1    35.5600  -20.0200   35.5600  -18.2700
            1    38.3600  -18.2700   38.3600  -20.0200
            1  4
 ORIGINAL  1   32
 REPEAT    1   33  34  35

» Japanese version   » Back

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (12)   

Download RDF
DBGET integrated database retrieval system