Entry |
|
Name |
Perphenazine maleate (JP18); PZC (TN) |
Formula |
C21H26ClN3OS. (C4H4O4)2
|
Exact mass |
635.1704
|
Mol weight |
636.113
|
Structure |
|
Simcomp |
|
Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
Remark |
Therapeutic category: | 1172 |
Product (DG00875): | D00503<JP/US> D02037<JP> D04038<JP> D04965<JP> |
|
Efficacy |
Antipsychotic, Dopamine D2 receptor antagonist |
Comment |
Phenothiazine derivative
|
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
Interaction |
|
Structure map |
map07029 | Antipsychotics - phenothiazines |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AB Phenothiazines with piperazine structure
N05AB03 Perphenazine
D02037 Perphenazine maleate (JP18) <JP>
USP drug classification [BR:br08302]
Antipsychotics
1st Generation/Typical
Perphenazine
D02037 Perphenazine maleate (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1172 Phenothiazines
D02037 Perphenazine maleate (JP18)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00875 Perphenazine
D02037 Perphenazine maleate
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00875 Perphenazine
D02037 Perphenazine maleate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00875 Perphenazine
D02037 Perphenazine maleate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D02037 Perphenazine maleate (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02037 Perphenazine maleate
D02037 Perphenazine maleate tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02037
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00875 Perphenazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00875 Perphenazine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00875 Perphenazine
|
Other DBs |
|
KCF data |
ATOM 43
1 C8x C 22.5990 -18.4898
2 C8x C 22.5990 -19.8851
3 C8x C 23.7851 -20.5828
4 C8y C 25.0409 -19.8851
5 C8y C 25.0409 -18.4898
6 C8x C 23.7851 -17.7224
7 S2x S 26.2269 -20.5828
8 C8y C 27.4129 -19.8851
9 C8y C 27.4129 -18.4898
10 N4y N 26.2269 -17.7224
11 C8x C 28.6687 -20.5828
12 C8x C 29.8548 -19.8851
13 C8y C 29.8548 -18.4898
14 C8x C 28.6687 -17.7224
15 C1b C 26.2269 -16.3270
16 C1b C 27.4129 -15.6294
17 C1b C 28.5990 -16.3270
18 N1y N 29.7850 -15.6294
19 C1x C 30.9710 -16.3270
20 C1x C 32.2268 -15.6294
21 N1y N 32.2268 -14.2340
22 C1x C 31.0408 -13.5364
23 C1x C 29.7850 -14.2340
24 C1b C 33.4129 -13.5364
25 C1b C 34.5989 -14.2340
26 O1a O 35.7850 -13.5364
27 X Cl 31.0408 -17.7224
28 C6a C 38.7336 -18.9644
29 C2b C 38.0607 -17.8036
30 O6a O 38.1360 -20.2005
31 O6a O 40.0797 -18.9581
32 C2b C 36.4492 -17.8098
33 C6a C 35.7825 -18.9767
34 O6a O 34.4364 -18.9767
35 O6a O 36.4617 -20.2066
36 C6a C 38.7336 -18.9644
37 C2b C 38.0607 -17.8036
38 C2b C 36.4492 -17.8098
39 C6a C 35.7825 -18.9767
40 O6a O 34.4364 -18.9767
41 O6a O 36.4617 -20.2066
42 O6a O 38.1360 -20.2005
43 O6a O 40.0797 -18.9581
BOND 44
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 8 11 2
13 11 12 1
14 12 13 2
15 13 14 1
16 9 14 2
17 10 15 1
18 15 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 22 23 1
26 18 23 1
27 21 24 1
28 24 25 1
29 25 26 1
30 13 27 1
31 28 29 1
32 28 30 1
33 28 31 2
34 29 32 2
35 32 33 1
36 33 34 1
37 33 35 2
38 36 37 1
39 36 42 1
40 36 43 2
41 37 38 2
42 38 39 1
43 39 40 1
44 39 41 2
BRACKET 1 33.3200 -20.8600 33.3200 -17.1500
1 40.8100 -17.1500 40.8100 -20.8600
1 2
ORIGINAL 1 28 29 32 33 34 35 30 31
REPEAT 1 36 37 38 39 40 41 42 43
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