| Entry |
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| Name |
Milrinone lactate;
Primacor (TN) |
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| Product |
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| Generic |
MILRINONE LACTATE (Armas Pharmaceuticals), MILRINONE LACTATE (Caplin Steriles Limited), MILRINONE LACTATE (Eugia US LLC), MILRINONE LACTATE (Fresenius Kabi USA), MILRINONE LACTATE (Hikma Pharmaceuticals USA), MILRINONE LACTATE (Hikma Pharmaceuticals USA), MILRINONE LACTATE (Hikma Pharmaceuticals USA), MILRINONE LACTATE (Hospira), MILRINONE LACTATE (Meitheal Pharmaceuticals), MILRINONE LACTATE (Mullan Pharmaceutical), MILRINONE LACTATE (Shandong New Time Pharmaceutical), MILRINONE LACTATE (Somerset Therapeutics), MILRINONE LACTATE IN DEXTROSE (Baxter Healthcare Corporation), MILRINONE LACTATE IN DEXTROSE (Gland Pharma Limited), MILRINONE LACTATE IN DEXTROSE (Hikma Pharmaceuticals USA), MILRINONE LACTATE IN DEXTROSE (Hospira), MILRINONE LACTATE IN DEXTROSE (Sagent Pharmaceuticals) |
|---|
| Formula |
C12H9N3O. (C3H6O3)x
|
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| Structure |
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| Class |
Cardiovascular agent
DG01703 Cardiotonic
DG01757 Amrinone type cardiotonic
DG01507 Phosphodiesterase III inhibitor
DG01757 Amrinone type cardiotonic
Metabolizing enzyme substrate
DG02924 UGT substrate
|
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| Remark |
| Product (DG00229): | D00417<JP> D02085<US> |
|
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| Efficacy |
Cardiotonic, Phosphodiesterase 3 inhibitor |
|---|
| Disease |
Acute decompensated heart failure [DS: H01631] |
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| Comment |
Amrinone derivative
|
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| Target |
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| Pathway |
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| Metabolism |
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
C01CE Phosphodiesterase inhibitors
C01CE02 Milrinone
D02085 Milrinone lactate <US>
Drug groups [BR:br08330]
Cardiovascular agent
DG01703 Cardiotonic
DG01757 Amrinone type cardiotonic
DG00229 Milrinone
D02085 Milrinone lactate
DG01507 Phosphodiesterase III inhibitor
DG01757 Amrinone type cardiotonic
DG00229 Milrinone
D02085 Milrinone lactate
Metabolizing enzyme substrate
DG02924 UGT substrate
DG00229 Milrinone
D02085 Milrinone lactate
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Phosphodiesterases
PDE3
D02085 Milrinone lactate <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02085
Drug groups [BR:br08330]
Cardiovascular agent
DG01703 Cardiotonic
DG01757 Amrinone type cardiotonic
DG00229 Milrinone
DG01507 Phosphodiesterase III inhibitor
DG01757 Amrinone type cardiotonic
DG00229 Milrinone
Metabolizing enzyme substrate
DG02924 UGT substrate
DG00229 Milrinone
|
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| Other DBs |
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| KCF data |
ATOM 22
1 C8y C 27.4735 -17.2583
2 C8y C 28.6858 -16.5588
3 C8x C 26.2669 -16.5588
4 C8y C 27.4735 -18.6570
5 C8x C 29.8983 -17.2583
6 C8x C 28.6858 -15.1599
7 C8y C 25.0487 -17.2583
8 N4x N 26.2669 -19.3624
9 C1a C 28.6801 -19.3565
10 C8x C 31.1165 -16.5705
11 C8x C 29.9040 -14.4604
12 C8y C 25.0487 -18.6570
13 C3b C 23.8364 -16.5588
14 N5x N 31.1165 -15.1599
15 O5x O 23.8364 -19.3624
16 N3a N 22.6239 -15.8594
17 C1c C 36.8899 -17.6785
18 C6a C 38.0965 -16.9908
19 C1a C 36.8840 -19.0833
20 O1a O 35.6776 -16.9849
21 O6a O 38.0905 -15.5919
22 O6a O 39.3088 -17.6901
BOND 22
1 2 6 1
2 3 7 2
3 4 8 1
4 4 9 1
5 5 10 1
6 6 11 2
7 7 12 1
8 7 13 1
9 10 14 2
10 12 15 2
11 13 16 3
12 8 12 1
13 11 14 1
14 1 2 1
15 1 3 1
16 1 4 2
17 2 5 2
18 17 18 1
19 17 19 1
20 17 20 1
21 18 21 2
22 18 22 1
BRACKET 1 34.0200 -19.8800 34.0200 -14.7000
1 40.8100 -14.7000 40.8100 -19.8800
1 x
ORIGINAL 1 17 18 19 20 21 22
REPEAT 1
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