KEGG   DRUG: Moricizine hydrochloride
Entry
D02087                      Drug                                   
Name
Moricizine hydrochloride (USP);
Ethmozine (TN)
Formula
C22H25N3O4S. HCl
Exact mass
463.1333
Mol weight
463.9775
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
Metabolizing enzyme inducer
 DG01637  CYP1A2 inducer
Remark
ATC code: C01BG01
Chemical structure group: DG00208
Efficacy
Antiarrhythmic, Sodium channel blocker
Comment
Phenothiazine derivative
Target
SCN5A [HSA:6331] [KO:K04838]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
Interaction
CYP induction: CYP1A2 [HSA:1544]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BG Other antiarrhythmics, class I and III
     C01BG01 Moracizine
      D02087  Moricizine hydrochloride (USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG00208  Moracizine
    D02087  Moricizine hydrochloride
 Metabolizing enzyme inducer
  DG01637  CYP1A2 inducer
   DG00208  Moracizine
    D02087  Moricizine hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN5A
     D02087  Moricizine hydrochloride (USP)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02087
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG00208  Moracizine
 Metabolizing enzyme inducer
  DG01637  CYP1A2 inducer
   DG00208  Moracizine
Other DBs
CAS: 29560-58-5
PubChem: 7849148
ChEBI: 60937
LigandBox: D02087
NIKKAJI: J423.006J
KCF data

ATOM        31
            1   C8y C    18.7714  -18.5969
            2   N1y N    17.5693  -17.8967
            3   C8y C    18.7714  -19.9974
            4   C8x C    19.9733  -17.8967
            5   C8y C    16.3498  -18.5969
            6   C5a C    17.5635  -16.5022
            7   S2x S    17.5693  -20.6976
            8   C8x C    19.9733  -20.6976
            9   C8y C    21.1871  -18.5969
            10  C8y C    16.3498  -19.9974
            11  C8x C    15.1361  -17.8967
            12  C1b C    18.7772  -15.8020
            13  O5a O    16.3440  -15.8020
            14  C8x C    21.1871  -19.9974
            15  N1b N    22.4008  -17.8910
            16  C8x C    15.1361  -20.6976
            17  C8x C    13.9166  -18.5969
            18  C1b C    18.7772  -14.4075
            19  C7a C    23.6145  -18.5853
            20  C8x C    13.9166  -19.9974
            21  N1y N    19.9209  -13.7014
            22  O7a O    24.8282  -17.8793
            23  O6a O    23.6145  -19.9916
            24  C1x C    21.1929  -14.4016
            25  C1x C    19.9850  -12.3009
            26  C1b C    26.0360  -18.5795
            27  C1x C    22.4067  -13.6956
            28  C1x C    21.1929  -11.6009
            29  C1a C    27.2496  -17.8736
            30  O2x O    22.4067  -12.2952
            31  X   Cl   31.0567  -17.9200
BOND        33
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 2
            10    5  11 1
            11    6  12 1
            12    6  13 2
            13    8  14 2
            14    9  15 1
            15   10  16 1
            16   11  17 2
            17   12  18 1
            18   15  19 1
            19   16  20 2
            20   18  21 1
            21   19  22 1
            22   19  23 2
            23   21  24 1
            24   21  25 1
            25   22  26 1
            26   24  27 1
            27   25  28 1
            28   26  29 1
            29   27  30 1
            30    7  10 1
            31    9  14 1
            32   17  20 1
            33   28  30 1

» Japanese version   » Back

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (12)   

Download RDF
DBGET integrated database retrieval system