Entry |
|
Name |
Colistin sulfate (JP18/USP); Coly-Mycin S; Colymycin S (TN) |
Formula |
(C52H97N16O13R)2. 5H2SO4
|
Structure |
|
Class |
Antibacterial
DG01579 Polypeptide antibiotic
|
Remark |
Product (DG00087): | D02049<JP/US> |
Product (mixture): | D02139<US> |
|
Efficacy |
Antibacterial, Cell membrane function inhibitor |
Comment |
Polypeptide
R: See Colistin sulfate [CPD: C13768]
|
Target |
Lipopolysaccharide |
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07A INTESTINAL ANTIINFECTIVES
A07AA Antibiotics
A07AA10 Colistin
D02138 Colistin sulfate (JP18/USP)
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01X OTHER ANTIBACTERIALS
J01XB Polymyxins
J01XB01 Colistin
D02138 Colistin sulfate (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
56 Purulent skin remedies
D02138 Colistin sulfate (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Colistin
D02138 Colistin sulfate (JP18/USP)
Drug groups [BR:br08330]
Antibacterial
DG01579 Polypeptide antibiotic
DG00087 Colistin
D02138 Colistin sulfate
Antimicrobials [BR:br08307]
Antibacterials
Cell membrane function inhibitor
Polypeptide
D02138 Colistin sulfate (JP18/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02138 Colistin sulfate
Drug groups [BR:br08330]
Antibacterial
DG01579 Polypeptide antibiotic
DG00087 Colistin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Cell membrane function inhibitor
Polypeptide
DG00087 Colistin
|
Other DBs |
|
KCF data |
ATOM 189
1 S4a S 43.7884 -14.0613
2 O1d O 43.7884 -15.4667
3 O1d O 45.1939 -14.0613
4 O1d O 43.7884 -12.6557
5 O1d O 42.3830 -14.0613
6 C1c C 29.0933 -19.7038
7 C1a C 30.3008 -20.4028
8 O1a O 27.8786 -20.4028
9 C1c C 25.4494 -11.7267
10 N1b N 25.4494 -13.1319
11 N1b N 27.8786 -11.7267
12 C5a C 26.6711 -11.0275
13 C5a C 30.3008 -11.7267
14 C1c C 29.0933 -11.0275
15 C1c C 32.7300 -11.7267
16 N1b N 31.5153 -11.0275
17 C5a C 24.2419 -13.8239
18 C1c C 24.2419 -15.2222
19 C1b C 25.4494 -15.9281
20 C1b C 25.4494 -17.3264
21 N1b N 26.6711 -18.0184
22 C5a C 27.8786 -17.3264
23 C1c C 29.0933 -18.0184
24 N1b N 30.3008 -17.3264
25 C5a C 31.5153 -18.0184
26 C1c C 32.7300 -17.3264
27 O5a O 26.6711 -9.6294
28 C1c C 35.1522 -11.7267
29 C1b C 33.9376 -11.0275
30 C1b C 29.0933 -9.3494
31 C5a C 32.7300 -13.1319
32 C1a C 36.3666 -11.0275
33 C1a C 35.1522 -13.1319
34 O5a O 31.5153 -13.8239
35 C1c C 30.3008 -8.6503
36 C1a C 31.5648 -9.3494
37 C1a C 30.3008 -7.2098
38 O5a O 30.3008 -13.1319
39 C1b C 24.2419 -11.0275
40 O5a O 23.0274 -13.1319
41 N1b N 23.0274 -15.9281
42 O5a O 27.8786 -15.9281
43 O5a O 31.5153 -19.4238
44 N1b N 32.7300 -15.9281
45 C5a C 34.1281 -15.9281
46 N1b N 33.9376 -13.8239
47 C1c C 34.8271 -14.7560
48 C1b C 36.2253 -14.7560
49 C1b C 33.9376 -18.0184
50 C1b C 33.9376 -19.4238
51 N1a N 35.1522 -20.1228
52 C1b C 24.2419 -9.6294
53 N1a N 23.0274 -8.9303
54 C5a C 21.8198 -15.2222
55 C1c C 20.6053 -15.9281
56 N1b N 19.3978 -15.2222
57 C5a C 18.1831 -15.9281
58 C1c C 16.9615 -15.2222
59 N1b N 15.7541 -15.9281
60 C5a C 14.5394 -15.2222
61 C1c C 13.3319 -15.9281
62 N1b N 12.1172 -15.2222
63 C5a C 10.9098 -15.9281
64 C1b C 9.6951 -15.2222
65 C1b C 8.4876 -15.9281
66 C1b C 7.2660 -15.2222
67 C1b C 6.0515 -15.9281
68 C1c C 4.8439 -15.2222
69 C1b C 3.6292 -15.9281
70 R R 2.4217 -15.2222
71 O5a O 21.8198 -13.8239
72 C1b C 20.6053 -17.3264
73 O5a O 18.1831 -17.3264
74 C1c C 16.9615 -13.4739
75 C1a C 15.7541 -12.7819
76 O1a O 18.1831 -12.7819
77 O5a O 14.5394 -13.8239
78 C1b C 13.3319 -17.3264
79 O5a O 10.9098 -17.3264
80 C1a C 4.8439 -13.8239
81 C1b C 19.3978 -18.0184
82 N1a N 19.3978 -19.4238
83 C1b C 12.1172 -18.0184
84 N1a N 12.1172 -19.4238
85 O5a O 34.8271 -17.1357
86 C1b C 36.9404 -15.9936
87 N1a N 38.3596 -15.9936
88 S4a S 43.7884 -14.0613
89 O1d O 43.7884 -15.4667
90 O1d O 45.1939 -14.0613
91 O1d O 43.7884 -12.6557
92 O1d O 42.3830 -14.0613
93 S4a S 43.7884 -14.0613
94 O1d O 43.7884 -15.4667
95 O1d O 45.1939 -14.0613
96 O1d O 43.7884 -12.6557
97 O1d O 42.3830 -14.0613
98 S4a S 43.7884 -14.0613
99 O1d O 43.7884 -15.4667
100 O1d O 45.1939 -14.0613
101 O1d O 43.7884 -12.6557
102 O1d O 42.3830 -14.0613
103 S4a S 43.7884 -14.0613
104 O1d O 43.7884 -15.4667
105 O1d O 45.1939 -14.0613
106 O1d O 43.7884 -12.6557
107 O1d O 42.3830 -14.0613
108 C1c C 29.0933 -19.7038
109 C1a C 30.3008 -20.4028
110 O1a O 27.8786 -20.4028
111 C1c C 29.0933 -18.0184
112 C5a C 27.8786 -17.3264
113 O5a O 27.8786 -15.9281
114 N1b N 26.6711 -18.0184
115 C1b C 25.4494 -17.3264
116 C1b C 25.4494 -15.9281
117 C1c C 24.2419 -15.2222
118 N1b N 23.0274 -15.9281
119 C5a C 21.8198 -15.2222
120 C1c C 20.6053 -15.9281
121 N1b N 19.3978 -15.2222
122 C5a C 18.1831 -15.9281
123 C1c C 16.9615 -15.2222
124 N1b N 15.7541 -15.9281
125 C5a C 14.5394 -15.2222
126 C1c C 13.3319 -15.9281
127 N1b N 12.1172 -15.2222
128 C5a C 10.9098 -15.9281
129 C1b C 9.6951 -15.2222
130 C1b C 8.4876 -15.9281
131 C1b C 7.2660 -15.2222
132 C1b C 6.0515 -15.9281
133 C1c C 4.8439 -15.2222
134 C1b C 3.6292 -15.9281
135 R R 2.4217 -15.2222
136 C1a C 4.8439 -13.8239
137 O5a O 10.9098 -17.3264
138 C1b C 13.3319 -17.3264
139 C1b C 12.1172 -18.0184
140 N1a N 12.1172 -19.4238
141 O5a O 14.5394 -13.8239
142 C1c C 16.9615 -13.4739
143 C1a C 15.7541 -12.7819
144 O1a O 18.1831 -12.7819
145 O5a O 18.1831 -17.3264
146 C1b C 20.6053 -17.3264
147 C1b C 19.3978 -18.0184
148 N1a N 19.3978 -19.4238
149 O5a O 21.8198 -13.8239
150 C5a C 24.2419 -13.8239
151 O5a O 23.0274 -13.1319
152 N1b N 25.4494 -13.1319
153 C1c C 25.4494 -11.7267
154 C1b C 24.2419 -11.0275
155 C1b C 24.2419 -9.6294
156 N1a N 23.0274 -8.9303
157 C5a C 26.6711 -11.0275
158 O5a O 26.6711 -9.6294
159 N1b N 27.8786 -11.7267
160 C1c C 29.0933 -11.0275
161 C1b C 29.0933 -9.3494
162 C1c C 30.3008 -8.6503
163 C1a C 31.5648 -9.3494
164 C1a C 30.3008 -7.2098
165 C5a C 30.3008 -11.7267
166 O5a O 30.3008 -13.1319
167 N1b N 31.5153 -11.0275
168 C1c C 32.7300 -11.7267
169 C1b C 33.9376 -11.0275
170 C1c C 35.1522 -11.7267
171 C1a C 36.3666 -11.0275
172 C1a C 35.1522 -13.1319
173 C5a C 32.7300 -13.1319
174 O5a O 31.5153 -13.8239
175 N1b N 33.9376 -13.8239
176 C1c C 34.8271 -14.7560
177 C5a C 34.1281 -15.9281
178 N1b N 32.7300 -15.9281
179 C1c C 32.7300 -17.3264
180 C5a C 31.5153 -18.0184
181 N1b N 30.3008 -17.3264
182 O5a O 31.5153 -19.4238
183 C1b C 33.9376 -18.0184
184 C1b C 33.9376 -19.4238
185 N1a N 35.1522 -20.1228
186 O5a O 34.8271 -17.1357
187 C1b C 36.2253 -14.7560
188 C1b C 36.9404 -15.9936
189 N1a N 38.3596 -15.9936
BOND 184
1 1 2 2
2 1 3 1
3 1 4 2
4 1 5 1
5 88 89 2
6 88 90 1
7 88 91 2
8 88 92 1
9 93 94 2
10 93 95 1
11 93 96 2
12 93 97 1
13 98 99 2
14 98 100 1
15 98 101 2
16 98 102 1
17 103 104 2
18 103 105 1
19 103 106 2
20 103 107 1
21 6 7 1
22 6 8 1
23 22 23 1
24 23 24 1
25 24 25 1
26 25 26 1
27 12 27 2
28 28 29 1
29 15 29 1
30 14 30 1
31 15 31 1
32 28 32 1
33 28 33 1
34 31 34 2
35 30 35 1
36 35 36 1
37 35 37 1
38 13 38 2
39 9 39 1
40 17 40 2
41 18 41 1
42 22 42 2
43 25 43 2
44 26 44 1
45 44 45 1
46 31 46 1
47 45 47 1
48 46 47 1
49 47 48 1
50 26 49 1
51 49 50 1
52 50 51 1
53 39 52 1
54 52 53 1
55 41 54 1
56 54 55 1
57 55 56 1
58 56 57 1
59 57 58 1
60 58 59 1
61 59 60 1
62 60 61 1
63 61 62 1
64 62 63 1
65 63 64 1
66 64 65 1
67 65 66 1
68 66 67 1
69 67 68 1
70 68 69 1
71 69 70 1
72 54 71 2
73 55 72 1
74 57 73 2
75 58 74 1
76 74 75 1
77 74 76 1
78 60 77 2
79 61 78 1
80 63 79 2
81 68 80 1
82 72 81 1
83 81 82 1
84 78 83 1
85 83 84 1
86 45 85 2
87 9 10 1
88 11 12 1
89 9 12 1
90 13 14 1
91 11 14 1
92 15 16 1
93 13 16 1
94 10 17 1
95 17 18 1
96 18 19 1
97 19 20 1
98 20 21 1
99 21 22 1
100 6 23 1
101 48 86 1
102 86 87 1
103 108 109 1
104 108 110 1
105 112 111 1
106 111 181 1
107 181 180 1
108 180 179 1
109 157 158 2
110 170 169 1
111 168 169 1
112 160 161 1
113 168 173 1
114 170 171 1
115 170 172 1
116 173 174 2
117 161 162 1
118 162 163 1
119 162 164 1
120 165 166 2
121 153 154 1
122 150 151 2
123 117 118 1
124 112 113 2
125 180 182 2
126 179 178 1
127 178 177 1
128 173 175 1
129 177 176 1
130 175 176 1
131 176 187 1
132 179 183 1
133 183 184 1
134 184 185 1
135 154 155 1
136 155 156 1
137 118 119 1
138 119 120 1
139 120 121 1
140 121 122 1
141 122 123 1
142 123 124 1
143 124 125 1
144 125 126 1
145 126 127 1
146 127 128 1
147 128 129 1
148 129 130 1
149 130 131 1
150 131 132 1
151 132 133 1
152 133 134 1
153 134 135 1
154 119 149 2
155 120 146 1
156 122 145 2
157 123 142 1
158 142 143 1
159 142 144 1
160 125 141 2
161 126 138 1
162 128 137 2
163 133 136 1
164 146 147 1
165 147 148 1
166 138 139 1
167 139 140 1
168 177 186 2
169 153 152 1
170 159 157 1
171 153 157 1
172 165 160 1
173 159 160 1
174 168 167 1
175 165 167 1
176 152 150 1
177 150 117 1
178 117 116 1
179 116 115 1
180 115 114 1
181 114 112 1
182 108 111 1
183 187 188 1
184 188 189 1
BRACKET 1 41.1600 -16.4500 41.1600 -11.5500
1 46.3400 -11.4800 46.3400 -16.3800
1 5
ORIGINAL 1 1 2 3 4 5
REPEAT 1 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103
1 104 105 106 107
2 2.2400 -21.1400 2.2400 -6.3700
2 39.7600 -6.3700 39.7600 -21.1400
2 2
ORIGINAL 2 6 7 8 23 22 42 21 20 19 18 41 54 55 56 57 58
2 59 60 61 62 63 64 65 66 67 68 69 70 80 79 78 83
2 84 77 74 75 76 73 72 81 82 71 17 40 10 9 39 52
2 53 12 27 11 14 30 35 36 37 13 38 16 15 29 28 32
2 33 31 34 46 47 45 44 26 25 24 43 49 50 51 85 48
2 86 87
REPEAT 2 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123
2 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139
2 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155
2 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171
2 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187
2 188 189
|