KEGG   DRUG: Mupirocin calcium
Entry
D02195                      Drug                                   
Name
Mupirocin calcium (USP);
Mupirocin calcium hydrate (JP18);
Mupirocin calcium dihydrate;
Bactroban (TN)
Product
  Generic
MUPIROCIN (Alembic Pharmaceuticals), MUPIROCIN (Amneal Pharmaceuticals NY LLC), MUPIROCIN (Bryant Ranch Prepack), MUPIROCIN (Bryant Ranch Prepack), MUPIROCIN (Encube Ethicals Private Limited), MUPIROCIN (Gabar Health Sciences Corp.), MUPIROCIN (Gabar Health Sciences Corp.), MUPIROCIN (Glenmark Pharmaceuticals), MUPIROCIN (NORTHSTAR RX LLC), MUPIROCIN (Padagis Israel Pharmaceuticals), MUPIROCIN (REMEDYREPACK), MUPIROCIN (Taro Pharmaceuticals U.S.A.), PIRNUO (Glenmark Pharmaceuticals)
Formula
(C26H43O9)2. 2H2O. Ca
Exact mass
1074.5651
Mol weight
1075.337
Structure
Remark
Therapeutic category: 6119
ATC code: D06AX09 R01AX06
Chemical structure group: DG00402
Product (DG00402): D01076<US> D02195<JP/US>
Efficacy
Antibacterial, tRNA Ligase inhibitor
  Disease
MRSA infection [DS:H00330]
Target
isoleucine tRNA ligase [KO:K01870]
  Pathway
ko00970  Aminoacyl-tRNA biosynthesis
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX09 Mupirocin
      D02195  Mupirocin calcium (USP) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AX Other nasal preparations
     R01AX06 Mupirocin
      D02195  Mupirocin calcium (USP) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Topical Anti-infectives
   Antibacterials, dermatological
    Mupirocin
     D02195  Mupirocin calcium (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   611  Acting mainly on gram-positive bacteria
    6119  Others
     D02195  Mupirocin calcium (USP); Mupirocin calcium hydrate (JP18)
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Other protein biosynthesis inhibitor
    D02195  Mupirocin calcium (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02195  Mupirocin calcium hydrate
  D02195  Mupirocin calcium ointment
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Other protein biosynthesis inhibitor
    DG00402  Mupirocin
Other DBs
CAS: 115074-43-6
PubChem: 7849255
ChEBI: 34858
LigandBox: D02195
NIKKAJI: J2.215.415J
KCF data

ATOM        73
            1   Z   Ca   26.4062  -21.9999 #2+
            2   C1y C    23.4532  -16.6787
            3   C1y C    23.4532  -18.0836
            4   C1x C    24.6667  -18.7824
            5   O2x O    25.8803  -18.0836
            6   C1y C    25.8803  -16.6787
            7   C1y C    24.6667  -15.9726
            8   C1y C    21.0316  -18.0907
            9   C1b C    22.2461  -18.7967
            10  O1a O    22.2408  -15.9833
            11  O1a O    24.6533  -14.5676
            12  C1b C    27.0892  -15.9726
            13  C2c C    28.3034  -16.6646
            14  C2b C    29.5178  -15.9657
            15  C7a C    30.7321  -16.6575
            16  O7a O    31.9395  -15.9585
            17  C1b C    33.1537  -16.6504
            18  C1b C    34.3681  -15.9514
            19  C1b C    35.5824  -16.6434
            20  C1b C    36.7966  -15.9445
            21  C1b C    38.0110  -16.6363
            22  C1b C    39.2254  -15.9374
            23  C1b C    40.4396  -16.6292
            24  C1b C    41.6469  -15.9302
            25  C6a C    42.8613  -16.6222
            26  O6a O    44.0757  -15.9162 #-
            27  C1a C    28.3065  -18.0695
            28  O6a O    30.7352  -18.0624
            29  O6a O    42.8674  -18.0272
            30  C1y C    19.8131  -18.7951
            31  C1c C    18.5962  -18.0878
            32  C1c C    17.3778  -18.7922
            33  C1a C    16.1609  -18.0849
            34  O2x O    21.0528  -19.4320
            35  O1a O    17.3761  -20.1972
            36  C1a C    18.5979  -16.6829
            37  O0  O    34.2096  -22.1025
            38  C1y C    23.4532  -16.6787
            39  O1a O    22.2408  -15.9833
            40  C1y C    23.4532  -18.0836
            41  C1b C    22.2461  -18.7967
            42  C1y C    21.0316  -18.0907
            43  O2x O    21.0528  -19.4320
            44  C1y C    19.8131  -18.7951
            45  C1c C    18.5962  -18.0878
            46  C1a C    18.5979  -16.6829
            47  C1c C    17.3778  -18.7922
            48  C1a C    16.1609  -18.0849
            49  O1a O    17.3761  -20.1972
            50  C1x C    24.6667  -18.7824
            51  O2x O    25.8803  -18.0836
            52  C1y C    25.8803  -16.6787
            53  C1y C    24.6667  -15.9726
            54  O1a O    24.6533  -14.5676
            55  C1b C    27.0892  -15.9726
            56  C2c C    28.3034  -16.6646
            57  C2b C    29.5178  -15.9657
            58  C7a C    30.7321  -16.6575
            59  O7a O    31.9395  -15.9585
            60  C1b C    33.1537  -16.6504
            61  C1b C    34.3681  -15.9514
            62  C1b C    35.5824  -16.6434
            63  C1b C    36.7966  -15.9445
            64  C1b C    38.0110  -16.6363
            65  C1b C    39.2254  -15.9374
            66  C1b C    40.4396  -16.6292
            67  C1b C    41.6469  -15.9302
            68  C6a C    42.8613  -16.6222
            69  O6a O    44.0757  -15.9162 #-
            70  O6a O    42.8674  -18.0272
            71  O6a O    30.7352  -18.0624
            72  C1a C    28.3065  -18.0695
            73  O0  O    34.2096  -22.1025
BOND        72
            1    32  33 1
            2     4   5 1
            3     8  34 1 #Up
            4    30  34 1 #Up
            5     5   6 1
            6    32  35 1 #Up
            7     6   7 1
            8    31  36 1 #Down
            9     8   9 1
            10    3   9 1 #Down
            11    2  10 1 #Up
            12    7  11 1 #Up
            13    6  12 1 #Down
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   13  27 1
            29   15  28 2
            30   25  29 2
            31    8  30 1
            32    2   3 1
            33   30  31 1
            34    2   7 1
            35   31  32 1
            36    3   4 1
            37   47  48 1
            38   50  51 1
            39   42  43 1 #Up
            40   44  43 1 #Up
            41   51  52 1
            42   47  49 1 #Up
            43   52  53 1
            44   45  46 1 #Down
            45   42  41 1
            46   40  41 1 #Down
            47   38  39 1 #Up
            48   53  54 1 #Up
            49   52  55 1 #Down
            50   55  56 1
            51   56  57 2
            52   57  58 1
            53   58  59 1
            54   59  60 1
            55   60  61 1
            56   61  62 1
            57   62  63 1
            58   63  64 1
            59   64  65 1
            60   65  66 1
            61   66  67 1
            62   67  68 1
            63   68  69 1
            64   56  72 1
            65   58  71 2
            66   68  70 2
            67   42  44 1
            68   38  40 1
            69   44  45 1
            70   38  53 1
            71   45  47 1
            72   40  50 1
BRACKET     1    14.4200  -20.6500   14.4200  -14.1400
            1    45.0800  -14.1400   45.0800  -20.6500
            1  2
 ORIGINAL  1    2  10   3   9   8  34  30  31  36  32  33  35   4   5   6   7
            1   11  12  13  14  15  16  17  18  19  20  21  22  23  24  25  26
            1   29  28  27
 REPEAT    1   38  39  40  41  42  43  44  45  46  47  48  49  50  51  52  53
            1   54  55  56  57  58  59  60  61  62  63  64  65  66  67  68  69
            1   70  71  72
            2    31.9200  -23.0300   31.9200  -21.2100
            2    35.0000  -21.2100   35.0000  -23.0300
            2  2
 ORIGINAL  2   37
 REPEAT    2   73

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