| Entry |
|
|---|
| Name |
Vincristine sulfate (JP18/USP);
VCR;
Marqibo (TN);
Oncovin (TN);
Vincasar (TN);
Vincrex (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C46H56N4O10. H2SO4
|
|---|
| Exact mass |
922.367
|
|---|
| Mol weight |
923.0361
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Source |
Catharanthus roseus [TAX: 4058]
|
|---|
| Class |
Antineoplastic
DG01965 Vinca alkaloid antineoplastic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 4240 |
| Product (DG00690): | D02197<JP/US> |
|
|---|
| Efficacy |
Antineoplastic, Tubulin polymerization inhibitor |
|---|
| Disease |
Acute lymphoblastic leukemia (Philadelphia chromosome-negative) [DS: H00001 H00002] Hodgkin's disease [DS: H00007] Non–Hodgkin's malignant lymphomas [DS: H02418] Rhabdomyosarcoma [DS: H00037] Neuroblastoma [DS: H00043] Wilms' tumor [DS: H02301] |
|---|
| Comment |
Vinca alkaloid
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07042 | Antineoplastics - agents from natural products |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
L01CA Vinca alkaloids and analogues
L01CA02 Vincristine
D02197 Vincristine sulfate (JP18/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
424 Plant extract preparations
4240 Plant extract preparations
D02197 Vincristine sulfate (JP18/USP)
Drug groups [BR:br08330]
Antineoplastic
DG01965 Vinca alkaloid antineoplastic
DG00690 Vincristine
D02197 Vincristine sulfate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00690 Vincristine
D02197 Vincristine sulfate
Target-based classification of drugs [BR:br08310]
Not elsewhere classified
Cellular process
Cytoskeleton
TUBB
D02197 Vincristine sulfate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02197 Vincristine sulfate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02197
Drug groups [BR:br08330]
Antineoplastic
DG01965 Vinca alkaloid antineoplastic
DG00690 Vincristine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00690 Vincristine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 65
1 S4a S 29.0733 -14.7233
2 O1d O 29.0733 -13.3233
3 O1d O 29.0733 -16.1233
4 O1d O 30.4733 -14.7233
5 O1d O 27.6733 -14.7233
6 C1z C 22.8169 -19.7891
7 C1y C 23.9475 -19.1224
8 C1y C 22.8227 -21.0939
9 C8y C 20.5671 -19.7891
10 C1x C 21.9820 -18.7107
11 C1z C 25.0900 -19.7834
12 N1y N 23.9359 -17.8003
13 C1z C 23.9591 -21.7433
14 N1y N 21.6862 -21.7433
15 C8y C 20.5671 -21.0939
16 C8x C 19.4305 -19.1397
17 C1x C 22.6430 -17.7950
18 C1y C 25.0316 -21.0997
19 C2x C 26.2207 -19.1108
20 C1b C 26.1859 -20.4155
21 C1x C 25.0841 -17.1393
22 C7a C 24.8522 -22.9221
23 O1a O 23.4663 -23.6453
24 C4a C 21.0426 -22.8391
25 C8x C 19.4305 -21.7492
26 C8y C 18.3230 -19.7834
27 O7a O 27.5332 -21.9476
28 C2x C 26.2264 -17.7887
29 C1a C 27.2991 -19.7777
30 O7a O 24.8414 -24.1920
31 C8y C 18.3230 -21.0939
32 C1z C 15.8281 -17.4039
33 C7a C 28.8147 -22.0060
34 C1a C 23.6751 -24.9167
35 O2a O 17.2097 -21.7317
36 C8y C 14.7033 -16.6443
37 C1x C 17.0921 -16.6676
38 C7a C 15.4686 -18.7029
39 C1a C 29.4468 -20.8753
40 O6a O 29.4700 -23.1018
41 C1a C 16.0965 -21.0822
42 C8y C 14.7033 -15.2991
43 N4x N 13.5783 -17.3170
44 C1y C 17.0921 -15.3803
45 O7a O 14.0307 -19.1610
46 O6a O 16.2977 -19.7351
47 C8y C 12.3896 -15.2991
48 C1x C 13.9784 -14.1973
49 C8y C 12.3896 -16.6443
50 C1x C 15.9557 -14.7657
51 C1x C 18.1760 -14.5627
52 C1a C 13.1608 -20.5816
53 C8x C 11.2473 -14.6324
54 C1x C 14.7495 -13.2116
55 C8x C 11.2473 -17.3170
56 N1y N 15.9557 -13.5247
57 C1z C 18.2171 -13.4205
58 C8x C 10.1688 -15.2991
59 C8x C 10.1688 -16.6443
60 C1x C 17.0864 -12.7710
61 C1b C 19.7248 -13.9481
62 O1a O 19.0579 -12.1273
63 C1a C 20.7858 -13.3103
64 O6a O 26.1576 -22.3898
65 O4a O 19.6700 -22.8285
BOND 72
1 1 2 2
2 1 3 2
3 1 4 1
4 1 5 1
5 6 7 1
6 6 8 1
7 6 9 1
8 6 10 1 #Up
9 7 11 1
10 7 12 1
11 8 13 1
12 8 14 1
13 9 15 2
14 9 16 1
15 10 17 1
16 11 18 1
17 11 19 1
18 11 20 1 #Down
19 12 21 1
20 13 22 1 #Down
21 13 23 1 #Up
22 14 24 1
23 15 25 1
24 16 26 2
25 18 27 1 #Up
26 19 28 2
27 20 29 1
28 22 30 1
29 25 31 2
30 32 26 1 #Down
31 27 33 1
32 30 34 1
33 31 35 1
34 32 36 1
35 32 37 1
36 32 38 1 #Up
37 33 39 1
38 33 40 2
39 35 41 1
40 36 42 2
41 36 43 1
42 37 44 1
43 38 45 1
44 38 46 2
45 42 47 1
46 42 48 1
47 43 49 1
48 44 50 1 #Down
49 44 51 1
50 45 52 1
51 47 53 1
52 48 54 1
53 49 55 1
54 56 50 1 #Down
55 51 57 1
56 53 58 2
57 55 59 2
58 56 60 1
59 57 61 1 #Down
60 57 62 1 #Up
61 61 63 1
62 12 17 1
63 13 18 1
64 14 15 1
65 21 28 1
66 26 31 1
67 47 49 2
68 54 56 1
69 57 60 1
70 58 59 1
71 22 64 2
72 24 65 2
|
|---|
