Entry |
|
Name |
Dihydroergotamine mesylate (USP); Dihydroergotamine mesilate (JP18); Migranal (TN); Trudhesa (TN) |
Product |
|
Generic |
DIHYDROERGOTAMINE MESYLATE (Advagen Pharma), DIHYDROERGOTAMINE MESYLATE (Apollo Pharmaceuticals), DIHYDROERGOTAMINE MESYLATE (Gland Pharma Limited), DIHYDROERGOTAMINE MESYLATE (Hikma Pharmaceuticals USA), DIHYDROERGOTAMINE MESYLATE (Hikma Pharmaceuticals USA), DIHYDROERGOTAMINE MESYLATE (Hikma Pharmaceuticals USA), DIHYDROERGOTAMINE MESYLATE (Oceanside Pharmaceuticals), DIHYDROERGOTAMINE MESYLATE (Padagis US LLC), DIHYDROERGOTAMINE MESYLATE (Provepharm), DIHYDROERGOTAMINE MESYLATE (Sagent Pharmaceuticals), DIHYDROERGOTAMINE MESYLATE NASAL (Cipla USA) |
Formula |
C33H37N5O5. CH4SO3
|
Exact mass |
679.2676
|
Mol weight |
679.783
|
Structure |
|
Simcomp |
|
Class |
Neuropsychiatric agent
DG01472 Dopamine agonist
DG01468 Dopamine D2-receptor agonist
DG01964 Ergot alkaloid
DG01982 Antimigraine, ergot alkaloid
Analgesic
DG01518 5-HT1B/1D-receptor agonist
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
Remark |
Product (DG00833): | D02211<US> |
|
Efficacy |
Antimigraine, Vasoconstrictor, Serotonin receptor agonist |
Comment |
Ergot alkaloid
Acute treatment of migraine headaches with or without aura
|
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
Interaction |
|
Structure map |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02C ANTIMIGRAINE PREPARATIONS
N02CA Ergot alkaloids
N02CA01 Dihydroergotamine
D02211 Dihydroergotamine mesylate (USP) <US>
USP drug classification [BR:br08302]
Antimigraine Agents
Ergot Alkaloids
Dihydroergotamine
D02211 Dihydroergotamine mesylate (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01472 Dopamine agonist
DG01468 Dopamine D2-receptor agonist
DG00833 Dihydroergotamine
D02211 Dihydroergotamine mesylate
DG01964 Ergot alkaloid
DG01982 Antimigraine, ergot alkaloid
DG00833 Dihydroergotamine
D02211 Dihydroergotamine mesylate
Analgesic
DG01518 5-HT1B/1D-receptor agonist
DG00833 Dihydroergotamine
D02211 Dihydroergotamine mesylate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00833 Dihydroergotamine
D02211 Dihydroergotamine mesylate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Serotonin
HTR1B
D02211 Dihydroergotamine mesylate (USP) <US>
HTR1D
D02211 Dihydroergotamine mesylate (USP) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02211 Dihydroergotamine mesilate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02211
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01472 Dopamine agonist
DG01468 Dopamine D2-receptor agonist
DG00833 Dihydroergotamine
DG01964 Ergot alkaloid
DG01982 Antimigraine, ergot alkaloid
DG00833 Dihydroergotamine
Analgesic
DG01518 5-HT1B/1D-receptor agonist
DG00833 Dihydroergotamine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00833 Dihydroergotamine
|
Other DBs |
|
KCF data |
ATOM 48
1 C1z C 21.8848 -14.3760
2 N1y N 21.8849 -15.6808
3 C1y C 23.0033 -13.6769
4 O2x O 20.7198 -13.6769
5 O1a O 21.8382 -13.0246
6 C1y C 23.0033 -16.3333
7 C5x C 19.5548 -15.6808
8 N1y N 24.1684 -14.3760
9 C1x C 23.0033 -12.3721
10 C1z C 19.5548 -14.3760
11 C5x C 24.1684 -15.6808
12 C1b C 23.0033 -17.6847
13 O5x O 18.6227 -16.6129
14 C1x C 25.2868 -13.7235
15 C1x C 25.2868 -12.3721
16 N1b N 17.8771 -13.6304
17 C1a C 19.5548 -12.9313
18 O5x O 25.2868 -16.3799
19 C8y C 24.1218 -18.3372
20 C5a C 16.3859 -14.3294
21 C8x C 24.1218 -19.6420
22 C8x C 25.2868 -17.6847
23 C1y C 16.3859 -15.6808
24 O5a O 15.2207 -13.6769
25 C8x C 25.2402 -20.2944
26 C8x C 26.4052 -18.3372
27 C1x C 15.2207 -16.3333
28 C1x C 17.5509 -16.3333
29 C8x C 26.4052 -19.6420
30 C1y C 15.2207 -17.6381
31 N1y N 17.5509 -17.6381
32 C8y C 14.1023 -18.2906
33 C1y C 16.3859 -18.3372
34 C1a C 18.6693 -18.3372
35 C8y C 14.1023 -19.6420
36 C8x C 12.9373 -17.6381
37 C1x C 16.3859 -19.6420
38 C8y C 15.2207 -20.2944
39 C8y C 12.9373 -20.2944
40 C8x C 11.8189 -18.2906
41 C8x C 15.2207 -21.5993
42 N4x N 12.9373 -21.5993
43 C8x C 11.8189 -19.6420
44 S4a S 30.3778 -16.8923
45 C1a C 28.9779 -16.8923
46 O1d O 31.7777 -16.8923
47 O1d O 30.3778 -15.4924
48 O1d O 30.3778 -18.2923
BOND 54
1 1 5 1 #Down
2 2 6 1
3 2 7 1
4 3 8 1
5 3 9 1
6 4 10 1
7 6 11 1
8 6 12 1 #Down
9 7 13 2
10 8 14 1
11 9 15 1
12 10 16 1
13 10 17 1 #Up
14 11 18 2
15 12 19 1
16 16 20 1
17 19 21 2
18 19 22 1
19 23 20 1 #Up
20 20 24 2
21 21 25 1
22 22 26 2
23 23 27 1
24 23 28 1
25 25 29 2
26 27 30 1
27 28 31 1
28 30 32 1
29 30 33 1
30 31 34 1
31 32 35 1
32 32 36 2
33 33 37 1
34 35 38 1
35 35 39 2
36 36 40 1
37 38 41 2
38 39 42 1
39 39 43 1
40 7 10 1
41 8 11 1
42 14 15 1
43 26 29 1
44 31 33 1
45 37 38 1
46 40 43 2
47 41 42 1
48 1 2 1
49 1 3 1
50 1 4 1
51 44 45 1
52 44 46 1
53 44 47 2
54 44 48 2
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