 | | DRUG: Sildenafil citrate | |
| Entry |
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| Name |
Sildenafil citrate (JAN/USP);
Revatio (TN);
Viagra (TN) |
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| Product |
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| Generic |
SILDENAFIL (A-S Medication Solutions), SILDENAFIL (A-S Medication Solutions), SILDENAFIL (A-S Medication Solutions), SILDENAFIL (A-S Medication Solutions), SILDENAFIL (A-S Medication Solutions), SILDENAFIL (A-S Medication Solutions), SILDENAFIL (ANI Pharmaceuticals), SILDENAFIL (Actavis Pharma), SILDENAFIL (Advagen Pharma), SILDENAFIL (Ajanta Pharma USA), SILDENAFIL (Ajanta Pharma USA), SILDENAFIL (American Health Packaging), SILDENAFIL (Amneal Pharmaceuticals LLC), SILDENAFIL (Amneal Pharmaceuticals NY LLC), SILDENAFIL (Amneal Pharmaceuticals NY LLC), SILDENAFIL (Amneal Pharmaceuticals NY LLC), SILDENAFIL (Aphena Pharma Solutions - Tennessee), SILDENAFIL (Aphena Pharma Solutions - Tennessee), SILDENAFIL (Aphena Pharma Solutions - Tennessee), SILDENAFIL (Aphena Pharma Solutions - Tennessee), SILDENAFIL (Aphena Pharma Solutions - Tennessee), SILDENAFIL (Appco Pharma LLC), SILDENAFIL (Asclemed USA), SILDENAFIL (Aurobindo Pharma Limited), SILDENAFIL (Aurobindo Pharma Limited), SILDENAFIL (AustarPharma LLC), SILDENAFIL (AvKARE), SILDENAFIL (AvPAK), SILDENAFIL (BluePoint Laboratories), SILDENAFIL (Bryant Ranch Prepack), SILDENAFIL (Bryant Ranch Prepack), SILDENAFIL (Bryant Ranch Prepack), SILDENAFIL (Bryant Ranch Prepack), SILDENAFIL (Bryant Ranch Prepack), SILDENAFIL (Bryant Ranch Prepack), SILDENAFIL (Bryant Ranch Prepack), SILDENAFIL (CIPLA USA INC.,), SILDENAFIL (Cadila Pharmaceuticals Limited), SILDENAFIL (Camber Pharmaceuticals), SILDENAFIL (Camber Pharmaceuticals), SILDENAFIL (Camber Pharmaceuticals), SILDENAFIL (Camber Pharmaceuticals), SILDENAFIL (Chartwell RX), SILDENAFIL (DIRECT RX), SILDENAFIL (DIRECT RX), SILDENAFIL (DirectRx), SILDENAFIL (Eugia US LLC), SILDENAFIL (Exelan Pharmaceuticals), SILDENAFIL (Greenstone LLC), SILDENAFIL (Lake Erie Medical DBA Quality Care Products LLC), SILDENAFIL (Lupin Pharmaceuticals), SILDENAFIL (Macleods Pharmaceuticals Limited), SILDENAFIL (Macleods Pharmaceuticals Limited), SILDENAFIL (Macleods Pharmaceuticals Limited), SILDENAFIL (McKesson Corporation dba SKY Packaging), SILDENAFIL (Medsource Pharmaceuticals), SILDENAFIL (Modavar Pharmaceuticals LLC), SILDENAFIL (Mylan Pharmaceuticals), SILDENAFIL (Northwind Pharmaceuticals), SILDENAFIL (Northwind Pharmaceuticals), SILDENAFIL (Northwind Pharmaceuticals), SILDENAFIL (Northwind Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (PD-Rx Pharmaceuticals), SILDENAFIL (PD-Rx Pharmaceuticals), SILDENAFIL (PD-Rx Pharmaceuticals), SILDENAFIL (PD-Rx Pharmaceuticals), SILDENAFIL (PD-Rx Pharmaceuticals), SILDENAFIL (Pharmasource Meds), SILDENAFIL (Preferred Pharmaceuticals), SILDENAFIL (Preferred Pharmaceuticals), SILDENAFIL (Proficient Rx LP), SILDENAFIL (Proficient Rx LP), SILDENAFIL (Proficient Rx LP), SILDENAFIL (Proficient Rx LP), SILDENAFIL (Proficient Rx LP), SILDENAFIL (Proficient Rx LP), SILDENAFIL (Proficient Rx LP), SILDENAFIL (Proficient Rx LP), SILDENAFIL (Proficient Rx LP), SILDENAFIL (Proficient Rx LP), SILDENAFIL (Quallent Pharmaceuticals Health LLC), SILDENAFIL (REMEDYREPACK), SILDENAFIL (REMEDYREPACK), SILDENAFIL (REMEDYREPACK), SILDENAFIL (REMEDYREPACK), SILDENAFIL (REMEDYREPACK), SILDENAFIL (RPK Pharmaceuticals), SILDENAFIL (RPK Pharmaceuticals), SILDENAFIL (RPK Pharmaceuticals), SILDENAFIL (RPK Pharmaceuticals), SILDENAFIL (Reyoung Corporation), SILDENAFIL (Taro Pharmaceuticals U.S.A.), SILDENAFIL (Teva Pharmaceuticals USA), SILDENAFIL (Teva Pharmaceuticals USA), SILDENAFIL (Tris Pharma), SILDENAFIL (TruPharma LLC), SILDENAFIL (Virtus Pharmaceuticals), SILDENAFIL (XLCARE Pharmaceuticals), SILDENAFIL (XLCare Pharmaceuticals), SILDENAFIL CITRATE (A-S Medication Solutions), SILDENAFIL CITRATE (A-S Medication Solutions), SILDENAFIL CITRATE (ANI Pharmaceuticals), SILDENAFIL CITRATE (Advagen Pharma), SILDENAFIL CITRATE (Advanced Rx Pharmacy of Tennessee), SILDENAFIL CITRATE (Ajanta Pharma USA), SILDENAFIL CITRATE (Ascend Laboratories), SILDENAFIL CITRATE (Asclemed USA), SILDENAFIL CITRATE (Asclemed USA), SILDENAFIL CITRATE (Aurobindo Pharma Limited), SILDENAFIL CITRATE (Bryant Ranch Prepack), SILDENAFIL CITRATE (Cardinal Health 107), SILDENAFIL CITRATE (Greenstone LLC), SILDENAFIL CITRATE (Major Pharmaceuticals), SILDENAFIL CITRATE (NIVAGEN PHARMACEUTICALS), SILDENAFIL CITRATE (Northwind Pharmaceuticals), SILDENAFIL CITRATE (Northwind Pharmaceuticals), SILDENAFIL CITRATE (Novadoz Pharmaceuticals LLC), SILDENAFIL CITRATE (NuCare Pharmaceuticals), SILDENAFIL CITRATE (NuCare Pharmaceuticals), SILDENAFIL CITRATE (NuCare Pharmaceuticals), SILDENAFIL CITRATE (PD-Rx Pharmaceuticals), SILDENAFIL CITRATE (PD-Rx Pharmaceuticals), SILDENAFIL CITRATE (Preferred Pharmaceuticals), SILDENAFIL CITRATE (Proficient Rx LP), SILDENAFIL CITRATE (Proficient Rx LP), SILDENAFIL CITRATE (Proficient Rx LP), SILDENAFIL CITRATE (Proficient Rx LP), SILDENAFIL CITRATE (Proficient Rx LP), SILDENAFIL CITRATE (Proficient Rx LP), SILDENAFIL CITRATE (Proficient Rx LP), SILDENAFIL CITRATE (Quality Care Products), SILDENAFIL CITRATE (Quallent Pharmaceuticals Health LLC), SILDENAFIL CITRATE (REMEDYREPACK), SILDENAFIL CITRATE (REMEDYREPACK), SILDENAFIL CITRATE (RedPharm Drug), SILDENAFIL CITRATE (Torrent Pharmaceuticals Limited), SILDENAFIL CITRATE (Torrent Pharmaceuticals Limited), SILDENAFIL CITRATE (TruPharma LLC), SILDENAFIL CITRATE (Zydus Lifesciences Limited), SILDENAFIL CITRATE (Zydus Pharmaceuticals (USA)) |
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| Formula |
C22H30N6O4S. C6H8O7
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| Exact mass |
666.2319
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| Mol weight |
666.6999
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| Structure |
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| Class |
Cardiovascular agent
DG01509 Phosphodiesterase V inhibitor
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Product (DG00484): | D02229<JP/US> |
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| Efficacy |
Vasodilator, Impotence therapy, Phosphodiesterase V inhibitor |
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| Disease |
Pulmonary arterial hypertension [DS: H01621] |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]; CYP2C9 [HSA: 1559]
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G04 UROLOGICALS
G04B UROLOGICALS
G04BE Drugs used in erectile dysfunction
G04BE03 Sildenafil
D02229 Sildenafil citrate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Respiratory Tract/Pulmonary Agents
Pulmonary Antihypertensives
Phosphodiesterase-5 (PDE5) Inhibitors
Sildenafil
D02229 Sildenafil citrate (JAN/USP)
Sexual Disorder Agents
Sexual Disorder Agents (Male)
Sildenafil
D02229 Sildenafil citrate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
219 Miscellaneous
2190 Miscellaneous
D02229 Sildenafil citrate (JAN/USP)
25 Urogenital and anal organ agents
259 Miscellaneous
2590 Miscellaneous
D02229 Sildenafil citrate (JAN/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01509 Phosphodiesterase V inhibitor
DG00484 Sildenafil
D02229 Sildenafil citrate
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00484 Sildenafil
D02229 Sildenafil citrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00484 Sildenafil
D02229 Sildenafil citrate
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Phosphodiesterases
PDE5
D02229 Sildenafil citrate (JAN/USP) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D02229
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02229
Drug groups [BR:br08330]
Cardiovascular agent
DG01509 Phosphodiesterase V inhibitor
DG00484 Sildenafil
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00484 Sildenafil
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00484 Sildenafil
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| Other DBs |
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| KCF data |
ATOM 46
1 C8y C 19.6408 -17.9141
2 C8y C 20.8539 -17.2084
3 C8y C 19.6408 -19.3198
4 C8x C 18.4275 -17.2200
5 N5x N 22.0613 -17.9083
6 N4x N 20.8423 -15.8085
7 C8x C 18.4275 -20.0196
8 O2a O 20.8423 -20.0139
9 C8y C 17.2201 -17.9141
10 C8y C 23.2804 -17.2141
11 C8y C 22.0613 -15.1086
12 C8x C 17.2144 -19.3139
13 C1b C 22.0496 -19.3139
14 S4a S 16.0128 -17.2141
15 C8y C 23.3444 -15.8143
16 C8y C 24.6102 -17.6399
17 O5x O 22.0613 -13.7030
18 C1a C 23.2511 -20.0139
19 N1y N 14.8055 -17.9083
20 O3c O 17.0043 -16.2168
21 O3c O 15.0096 -16.2168
22 N4y N 24.6044 -15.3711
23 N5x N 25.4385 -16.5025
24 C1b C 25.0359 -18.9640
25 C1x C 14.8055 -19.3082
26 C1x C 13.5923 -17.2025
27 C1a C 25.0419 -14.0353
28 C1b C 26.3950 -19.2498
29 C1x C 13.5923 -20.0081
30 C1x C 12.3792 -17.9083
31 C1a C 26.8265 -20.5797
32 N1y N 12.3792 -19.3082
33 C1a C 11.1718 -20.0139
34 C1d C 31.4778 -17.1503
35 C1b C 30.2633 -17.8509
36 C1b C 32.6923 -17.8509
37 C6a C 32.1785 -15.9358
38 O1a O 30.7771 -15.9358
39 C6a C 29.0489 -17.1970
40 C6a C 32.6923 -19.2523
41 O6a O 31.4778 -14.7213
42 O6a O 33.5798 -15.9358
43 O6a O 27.8344 -17.8976
44 O6a O 29.0489 -15.7957
45 O6a O 33.9067 -19.9529
46 O6a O 31.4778 -19.9529
BOND 48
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 6 11 1
11 7 12 1
12 8 13 1
13 9 14 1
14 10 15 2
15 10 16 1
16 11 17 2
17 13 18 1
18 14 19 1
19 14 20 2
20 14 21 2
21 15 22 1
22 16 23 2
23 16 24 1
24 19 25 1
25 19 26 1
26 22 27 1
27 24 28 1
28 25 29 1
29 26 30 1
30 28 31 1
31 29 32 1
32 32 33 1
33 9 12 2
34 11 15 1
35 22 23 1
36 30 32 1
37 34 35 1
38 34 36 1
39 34 37 1
40 34 38 1
41 35 39 1
42 36 40 1
43 37 41 1
44 37 42 2
45 39 43 1
46 39 44 2
47 40 45 1
48 40 46 2
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