KEGG   DRUG: Cyproheptadine hydrochloride
Entry
D02234                      Drug                                   
Name
Cyproheptadine hydrochloride (JP18/USP);
Cyproheptadine hydrochloride sesquihydrate;
Periactin (TN)
Product
  Generic
CYPROHEPTADINE (Chartwell RX), CYPROHEPTADINE HYDROCHLORIDE (A-S Medication Solutions), CYPROHEPTADINE HYDROCHLORIDE (A-S Medication Solutions), CYPROHEPTADINE HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), CYPROHEPTADINE HYDROCHLORIDE (AvPAK), CYPROHEPTADINE HYDROCHLORIDE (Bayshore Pharmaceuticals LLC), CYPROHEPTADINE HYDROCHLORIDE (Bryant Ranch Prepack), CYPROHEPTADINE HYDROCHLORIDE (Bryant Ranch Prepack), CYPROHEPTADINE HYDROCHLORIDE (Bryant Ranch Prepack), CYPROHEPTADINE HYDROCHLORIDE (Chartwell RX), CYPROHEPTADINE HYDROCHLORIDE (Golden State Medical Supply), CYPROHEPTADINE HYDROCHLORIDE (Ingenus Pharmaceuticals LLC), CYPROHEPTADINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), CYPROHEPTADINE HYDROCHLORIDE (Patrin Pharma), CYPROHEPTADINE HYDROCHLORIDE (Proficient Rx LP), CYPROHEPTADINE HYDROCHLORIDE (Proficient Rx LP), CYPROHEPTADINE HYDROCHLORIDE (QPharma), CYPROHEPTADINE HYDROCHLORIDE (QUAGEN PHARMACEUTICALS LLC), CYPROHEPTADINE HYDROCHLORIDE (QUAGEN PHARMACEUTICALS LLC), CYPROHEPTADINE HYDROCHLORIDE (REMEDYREPACK), CYPROHEPTADINE HYDROCHLORIDE (REMEDYREPACK), CYPROHEPTADINE HYDROCHLORIDE (Rising Pharma Holdings), CYPROHEPTADINE HYDROCHLORIDE (Rising Pharmaceuticals), CYPROHEPTADINE HYDROCHLORIDE (Strides Pharma Science Limited), CYPROHEPTADINE HYDROCHLORIDE (TRUPHARMA), CYPROHEPTADINE HYDROCHLORIDE (Tris Pharma), CYPROHEPTADINE HYDROCHLORIDE (VistaPharm), CYPROHEPTADINE HYDROCHLORIDE (Westminster Pharmaceuticals), CYPROHEPTADINE HYDROCHLORIDE (Zydus Lifesciences Limited), CYPROHEPTADINE HYDROCHLORIDE (Zydus Pharmaceuticals USA)
Formula
(C21H21N)2. 2HCl. 3H2O
Exact mass
700.3198
Mol weight
701.764
Structure
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Remark
Therapeutic category: 4419
ATC code: R06AX02
Chemical structure group: DG01109
Product (DG01109): D02234<JP/US>
Efficacy
Antiallergic, Antipruritic, H1 receptor antagonist, Serotonin receptor antagonist
  Disease
Perennial and seasonal allergic rhinitis [DS:H01360]
Comment
Tricyclic, loratadine derivative
Target
HRH1 [HSA:3269] [KO:K04149]
HTR2 [HSA:3356 3357 3358] [KO:K04157]
HTR1 [HSA:3350 3351 3352 3354 3355] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
Interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AX Other antihistamines for systemic use
     R06AX02 Cyproheptadine
      D02234  Cyproheptadine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Histamine (H1) Receptor Antagonists, Sedating
    Cyproheptadine
     D02234  Cyproheptadine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4419  Others
     D02234  Cyproheptadine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01109  Cyproheptadine
     D02234  Cyproheptadine hydrochloride
Drug classes [BR:br08332]
 Anti-allergic agent
  DG01482  Histamine receptor H1 antagonist
   D02234  Cyproheptadine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D02234  Cyproheptadine hydrochloride (JP18/USP) <JP/US>
   Serotonin
    HTR1
     D02234  Cyproheptadine hydrochloride (JP18/USP) <JP/US>
    HTR2
     D02234  Cyproheptadine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02234  Cyproheptadine hydrochloride
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01109  Cyproheptadine
Other DBs
CAS: 41354-29-4
PubChem: 7849293
ChEBI: 650917
LigandBox: D02234
NIKKAJI: J2.221.455A
KCF data

ATOM        49
            1   X   Cl   29.9601  -12.3900
            2   O0  O    30.5201  -15.4700
            3   C2x C    21.6757  -18.3177
            4   C8y C    20.8313  -17.2050
            5   C8y C    21.1674  -15.8445
            6   C2y C    22.4319  -15.2648
            7   C2x C    23.0854  -18.3430
            8   C8y C    23.6889  -15.8888
            9   C8y C    23.9762  -17.2613
            10  C8x C    20.1575  -14.8734
            11  C8x C    18.8118  -15.2626
            12  C8x C    18.4757  -16.6231
            13  C8x C    19.4856  -17.5939
            14  C8x C    25.3110  -17.6996
            15  C8x C    26.3581  -16.7626
            16  C8x C    26.0710  -15.3901
            17  C8x C    24.7359  -14.9518
            18  C2y C    22.4319  -13.8648
            19  C1x C    23.6222  -13.1772
            20  C1x C    23.6218  -11.7772
            21  N1y N    22.4092  -11.0775
            22  C1x C    21.2189  -11.7651
            23  C1x C    21.2193  -13.1651
            24  C1a C    22.4089   -9.6600
            25  X   Cl   29.9601  -12.3900
            26  O0  O    30.5201  -15.4700
            27  O0  O    30.5201  -15.4700
            28  C2x C    21.6757  -18.3177
            29  C2x C    23.0854  -18.3430
            30  C8y C    23.9762  -17.2613
            31  C8y C    23.6889  -15.8888
            32  C2y C    22.4319  -15.2648
            33  C8y C    21.1674  -15.8445
            34  C8y C    20.8313  -17.2050
            35  C8x C    19.4856  -17.5939
            36  C8x C    18.4757  -16.6231
            37  C8x C    18.8118  -15.2626
            38  C8x C    20.1575  -14.8734
            39  C2y C    22.4319  -13.8648
            40  C1x C    23.6222  -13.1772
            41  C1x C    23.6218  -11.7772
            42  N1y N    22.4092  -11.0775
            43  C1x C    21.2189  -11.7651
            44  C1x C    21.2193  -13.1651
            45  C1a C    22.4089   -9.6600
            46  C8x C    24.7359  -14.9518
            47  C8x C    26.0710  -15.3901
            48  C8x C    26.3581  -16.7626
            49  C8x C    25.3110  -17.6996
BOND        50
            1     5   6 1
            2     3   7 2
            3     6   8 1
            4     4   5 1
            5     7   9 1
            6     3   4 1
            7     8   9 1
            8     5  10 2
            9    10  11 1
            10   11  12 2
            11   12  13 1
            12    4  13 2
            13    9  14 2
            14   14  15 1
            15   15  16 2
            16   16  17 1
            17    8  17 2
            18    6  18 2
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 1
            23   22  23 1
            24   18  23 1
            25   21  24 1
            26   33  32 1
            27   28  29 2
            28   32  31 1
            29   34  33 1
            30   29  30 1
            31   28  34 1
            32   31  30 1
            33   33  38 2
            34   38  37 1
            35   37  36 2
            36   36  35 1
            37   34  35 2
            38   30  49 2
            39   49  48 1
            40   48  47 2
            41   47  46 1
            42   31  46 2
            43   32  39 2
            44   39  40 1
            45   40  41 1
            46   41  42 1
            47   42  43 1
            48   43  44 1
            49   39  44 1
            50   42  45 1
BRACKET     1    28.2800  -13.3000   28.2800  -11.4100
            1    30.9400  -11.4100   30.9400  -13.3000
            1  2
 ORIGINAL  1    1
 REPEAT    1   25
            2    28.3500  -16.3800   28.3500  -14.5600
            2    31.3600  -14.5600   31.3600  -16.3800
            2  3
 ORIGINAL  2    2
 REPEAT    2   26  27
            3    18.2700  -18.7600   18.2700   -9.1700
            3    26.9500   -9.1700   26.9500  -18.7600
            3  2
 ORIGINAL  3    3   7   9   8   6   5   4  13  12  11  10  18  19  20  21  22
            3   23  24  17  16  15  14
 REPEAT    3   28  29  30  31  32  33  34  35  36  37  38  39  40  41  42  43
            3   44  45  46  47  48  49

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