| Entry |
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| Name |
Guanethidine sulfate (USAN) |
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| Formula |
(C10H22N4)2. H2SO4
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| Exact mass |
494.3363
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| Mol weight |
494.6954
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| Structure |
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| Class |
Cardiovascular agent
DG01739 Peripherally-acting antiadrenergic
Neuropsychiatric agent
DG03085 Selective norepinephrine reuptake inhibitor (NRI)
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
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| Remark |
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| Efficacy |
Antihypertensive, Noradrenaline release inhibitor |
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| Comment |
Guanidine derivative
|
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| Target |
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| Pathway |
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C02 ANTIHYPERTENSIVES
C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
C02CC Guanidine derivatives
C02CC02 Guanethidine
D02237 Guanethidine sulfate (USAN)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EX Other antiglaucoma preparations
S01EX01 Guanethidine
D02237 Guanethidine sulfate (USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01739 Peripherally-acting antiadrenergic
DG00258 Guanethidine
D02237 Guanethidine sulfate
Neuropsychiatric agent
DG03085 Selective norepinephrine reuptake inhibitor (NRI)
DG00258 Guanethidine
D02237 Guanethidine sulfate
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00258 Guanethidine
D02237 Guanethidine sulfate
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D02237 Guanethidine sulfate (USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01739 Peripherally-acting antiadrenergic
DG00258 Guanethidine
Neuropsychiatric agent
DG03085 Selective norepinephrine reuptake inhibitor (NRI)
DG00258 Guanethidine
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00258 Guanethidine
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| Other DBs |
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| KCF data |
ATOM 33
1 N1y N 21.4998 -15.4594
2 C1b C 20.2881 -14.7604
3 C1x C 21.4998 -16.9041
4 C1x C 22.5250 -14.4341
5 C1b C 19.1231 -15.4594
6 C1x C 22.4784 -17.8828
7 C1x C 23.9230 -14.4341
8 N1b N 17.9581 -14.7604
9 C1x C 23.9230 -17.8828
10 C1x C 24.9017 -15.4128
11 C2c C 16.7464 -15.4594
12 C1x C 24.9017 -16.9041
13 N1a N 15.5813 -14.7604
14 N2a N 16.7464 -16.8109
15 S4a S 30.1701 -16.4848
16 O1d O 30.1701 -15.0862
17 O1d O 30.1701 -17.8833
18 O1d O 31.5686 -16.4848
19 O1d O 28.7716 -16.4848
20 N1y N 21.4998 -15.4594
21 C1b C 20.2881 -14.7604
22 C1b C 19.1231 -15.4594
23 N1b N 17.9581 -14.7604
24 C2c C 16.7464 -15.4594
25 N1a N 15.5813 -14.7604
26 N2a N 16.7464 -16.8109
27 C1x C 21.4998 -16.9041
28 C1x C 22.4784 -17.8828
29 C1x C 23.9230 -17.8828
30 C1x C 24.9017 -16.9041
31 C1x C 24.9017 -15.4128
32 C1x C 23.9230 -14.4341
33 C1x C 22.5250 -14.4341
BOND 32
1 15 16 2
2 15 17 2
3 15 18 1
4 15 19 1
5 1 2 1
6 1 3 1
7 1 4 1
8 2 5 1
9 3 6 1
10 4 7 1
11 5 8 1
12 6 9 1
13 7 10 1
14 8 11 1
15 9 12 1
16 11 13 1
17 11 14 2
18 10 12 1
19 20 21 1
20 20 27 1
21 20 33 1
22 21 22 1
23 27 28 1
24 33 32 1
25 22 23 1
26 28 29 1
27 32 31 1
28 23 24 1
29 29 30 1
30 24 25 1
31 24 26 2
32 31 30 1
BRACKET 1 13.5100 -18.6900 13.5100 -13.0200
1 25.3400 -13.0200 25.3400 -18.6900
1 2
ORIGINAL 1 1 2 5 8 11 13 14 3 6 9 12 10 7 4
REPEAT 1 20 21 22 23 24 25 26 27 28 29 30 31 32 33
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